ID LIAT1_HUMAN Reviewed; 453 AA. AC Q6ZQX7; A5D8T6; Q6NSI2; Q6PFW9; DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot. DT 05-APR-2011, sequence version 2. DT 22-FEB-2023, entry version 113. DE RecName: Full=Protein LIAT1 {ECO:0000305}; DE AltName: Full=Ligand of ATE1 protein {ECO:0000305}; GN Name=LIAT1 {ECO:0000305}; Synonyms=C17orf97 {ECO:0000312|HGNC:HGNC:33800}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLU-220. RC TISSUE=Stomach; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 12-453 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE RP MRNA] OF 21-453 (ISOFORM 4), AND VARIANTS LYS-56 AND GLU-220. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP DOMAIN. RX PubMed=25369936; DOI=10.1073/pnas.1419587111; RA Brower C.S., Rosen C.E., Jones R.H., Wadas B.C., Piatkov K.I., RA Varshavsky A.; RT "Liat1, an arginyltransferase-binding protein whose evolution among RT primates involved changes in the numbers of its 10-residue repeats."; RL Proc. Natl. Acad. Sci. U.S.A. 111:E4936-E4945(2014). CC -!- FUNCTION: May be involved in ATE1-mediated N-terminal arginylation. CC {ECO:0000250|UniProtKB:Q810M6}. CC -!- SUBUNIT: Interacts with ATE1; it is not a substrate of LIAT1. Interacts CC with JMJD6 and MRPS14 (By similarity). {ECO:0000250|UniProtKB:Q810M6}. CC -!- INTERACTION: CC Q6ZQX7-4; P68133: ACTA1; NbExp=3; IntAct=EBI-25830459, EBI-367510; CC Q6ZQX7-4; P13637: ATP1A3; NbExp=3; IntAct=EBI-25830459, EBI-948169; CC Q6ZQX7-4; P08684: CYP3A4; NbExp=3; IntAct=EBI-25830459, EBI-3928618; CC Q6ZQX7-4; P03372: ESR1; NbExp=3; IntAct=EBI-25830459, EBI-78473; CC Q6ZQX7-4; P10809: HSPD1; NbExp=3; IntAct=EBI-25830459, EBI-352528; CC Q6ZQX7-4; P16284: PECAM1; NbExp=3; IntAct=EBI-25830459, EBI-716404; CC Q6ZQX7-4; Q13393: PLD1; NbExp=3; IntAct=EBI-25830459, EBI-2827556; CC Q6ZQX7-4; P05771-2: PRKCB; NbExp=3; IntAct=EBI-25830459, EBI-5774511; CC Q6ZQX7-4; P20339: RAB5A; NbExp=3; IntAct=EBI-25830459, EBI-399437; CC Q6ZQX7-4; P08670: VIM; NbExp=3; IntAct=EBI-25830459, EBI-353844; CC Q6ZQX7-4; P04275-2: VWF; NbExp=3; IntAct=EBI-25830459, EBI-25896548; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q6ZQX7-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6ZQX7-2; Sequence=VSP_034197, VSP_034198; CC Name=3; CC IsoId=Q6ZQX7-3; Sequence=VSP_034195; CC Name=4; CC IsoId=Q6ZQX7-4; Sequence=VSP_034196; CC -!- DOMAIN: LIAT1 proteins of some primates, from macaques to humans, CC contain tandem repeats of a 10-residue sequence, whereas LIAT1 proteins CC of other mammals contain a single copy of this motif. Quantities of CC these repeats are, in general, different in LIAT1 of different CC primates. For example, there are 1, 4, 13, 13, 17, and 17 repeats in CC the gibbon, gorilla, orangutan, bonobo, neanderthal, and human LIAT1, CC respectively. {ECO:0000305|PubMed:25369936}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK128660; BAC87555.1; -; mRNA. DR EMBL; AC141424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC057385; AAH57385.1; -; mRNA. DR EMBL; BC070116; AAH70116.2; -; mRNA. DR EMBL; BC141806; AAI41807.1; -; mRNA. DR CCDS; CCDS32519.2; -. [Q6ZQX7-4] DR RefSeq; NP_001013694.4; NM_001013672.4. [Q6ZQX7-4] DR AlphaFoldDB; Q6ZQX7; -. DR BioGRID; 134634; 3. DR IntAct; Q6ZQX7; 12. DR MINT; Q6ZQX7; -. DR STRING; 9606.ENSP00000353245; -. DR iPTMnet; Q6ZQX7; -. DR PhosphoSitePlus; Q6ZQX7; -. DR BioMuta; C17orf97; -. DR DMDM; 327478504; -. DR EPD; Q6ZQX7; -. DR MassIVE; Q6ZQX7; -. DR MaxQB; Q6ZQX7; -. DR PeptideAtlas; Q6ZQX7; -. DR ProteomicsDB; 68096; -. [Q6ZQX7-1] DR ProteomicsDB; 68097; -. [Q6ZQX7-2] DR ProteomicsDB; 68098; -. [Q6ZQX7-3] DR ProteomicsDB; 68099; -. [Q6ZQX7-4] DR Antibodypedia; 10251; 47 antibodies from 13 providers. DR DNASU; 400566; -. DR Ensembl; ENST00000360127.7; ENSP00000353245.6; ENSG00000187624.9. [Q6ZQX7-4] DR Ensembl; ENST00000639297.2; ENSP00000491943.1; ENSG00000283985.2. [Q6ZQX7-4] DR GeneID; 400566; -. DR KEGG; hsa:400566; -. DR MANE-Select; ENST00000360127.7; ENSP00000353245.6; NM_001013672.5; NP_001013694.4. [Q6ZQX7-4] DR UCSC; uc021tna.1; human. [Q6ZQX7-1] DR AGR; HGNC:33800; -. DR CTD; 400566; -. DR DisGeNET; 400566; -. DR GeneCards; C17orf97; -. DR HGNC; HGNC:33800; C17orf97. DR HPA; ENSG00000187624; Tissue enriched (testis). DR neXtProt; NX_Q6ZQX7; -. DR OpenTargets; ENSG00000187624; -. DR PharmGKB; PA162378582; -. DR VEuPathDB; HostDB:ENSG00000187624; -. DR eggNOG; ENOG502SC86; Eukaryota. DR GeneTree; ENSGT00440000038370; -. DR HOGENOM; CLU_049741_0_0_1; -. DR InParanoid; Q6ZQX7; -. DR OMA; LKGFHTD; -. DR OrthoDB; 4608733at2759; -. DR PhylomeDB; Q6ZQX7; -. DR TreeFam; TF337007; -. DR PathwayCommons; Q6ZQX7; -. DR SignaLink; Q6ZQX7; -. DR BioGRID-ORCS; 400566; 15 hits in 1120 CRISPR screens. DR GenomeRNAi; 400566; -. DR Pharos; Q6ZQX7; Tdark. DR PRO; PR:Q6ZQX7; -. DR Proteomes; UP000005640; Chromosome 17. DR RNAct; Q6ZQX7; protein. DR Bgee; ENSG00000187624; Expressed in left testis and 98 other tissues. DR ExpressionAtlas; Q6ZQX7; baseline and differential. DR Genevisible; Q6ZQX7; HS. DR GO; GO:0016598; P:protein arginylation; ISS:UniProtKB. DR InterPro; IPR038794; LIAT1. DR PANTHER; PTHR36474; PROTEIN LIAT1; 1. DR PANTHER; PTHR36474:SF1; PROTEIN LIAT1; 1. PE 1: Evidence at protein level; KW Alternative splicing; Reference proteome; Repeat. FT CHAIN 1..453 FT /note="Protein LIAT1" FT /id="PRO_0000340233" FT REPEAT 201..210 FT /note="1" FT REPEAT 211..220 FT /note="2" FT REPEAT 221..230 FT /note="3" FT REPEAT 231..240 FT /note="4" FT REPEAT 241..250 FT /note="5" FT REPEAT 251..260 FT /note="6" FT REPEAT 261..270 FT /note="7" FT REPEAT 271..280 FT /note="8" FT REPEAT 281..290 FT /note="9" FT REPEAT 291..300 FT /note="10" FT REPEAT 301..310 FT /note="11" FT REPEAT 311..320 FT /note="12" FT REPEAT 321..330 FT /note="13" FT REPEAT 331..340 FT /note="14" FT REPEAT 341..350 FT /note="15" FT REPEAT 351..360 FT /note="16" FT REPEAT 361..370 FT /note="17" FT REPEAT 371..380 FT /note="18" FT REPEAT 381..390 FT /note="19" FT REPEAT 391..400 FT /note="20" FT REGION 1..152 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 145..197 FT /note="Interaction with ATE1" FT /evidence="ECO:0000250|UniProtKB:Q810M6" FT REGION 201..400 FT /note="20 X 10 AA approximate tandem repeat of A-L-K-G-F-H- FT P-D-P-E" FT REGION 225..306 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 320..432 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 43..63 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 82..97 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 124..145 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 320..400 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 412..426 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 201..220 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_034195" FT VAR_SEQ 236..265 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_034196" FT VAR_SEQ 256..265 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_034197" FT VAR_SEQ 348..367 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_034198" FT VARIANT 56 FT /note="E -> K (in dbSNP:rs4581766)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_044008" FT VARIANT 220 FT /note="D -> E (in dbSNP:rs35229416)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334" FT /id="VAR_044009" FT CONFLICT 105 FT /note="Q -> L (in Ref. 3; AAI41807)" FT /evidence="ECO:0000305" FT CONFLICT 114 FT /note="L -> P (in Ref. 3; AAH57385)" FT /evidence="ECO:0000305" FT CONFLICT 240 FT /note="E -> D (in Ref. 3; AAH57385)" FT /evidence="ECO:0000305" SQ SEQUENCE 453 AA; 49656 MW; B6EB88592B0ED514 CRC64; METRGPGLAV RAESRRLVGI GPRAPPGRVG LQPSGRLDRR GGAGTMGYKD NDGEEEEREG GAAGPRGSRL PPITGGASEL AKRKVKKKKR KKKTKGSGKG DDKHQSQSLK SQPLSSSFHD ILSPCKERGP KPEHRQSKVE KKHLPSDSST VSLPDFAEIE NLANRINESL RWDGILADPE AEKERIRIYK LNRRKRYRCL ALKGFHPDPE ALKGFHPDPD ALKGFHPDPE ALKGFHPDPE ALKGFHPDPE ALKGFHPDPE ALKGIHPDPE ALKGIHPDPE ALKGFHPDPE ALKGFHPDPE ALKGFHTDPE ALKGFHIDPE ALKGFHPDPK ALKGFHPDPK ALKGFHTDPE ALKGFHPDPK ALKGFHPDPE ALKGFHPDPE ALKGFHPDPE ALKGFHTDPN AEEAPENLPY LSDKDGSSSH RQPTSKAECP NLCFEGNLTP KLLHSDLAPT LLE //