ID S35A3_BOVIN Reviewed; 326 AA. AC Q6YC49; A7Z022; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 05-DEC-2018, entry version 99. DE RecName: Full=UDP-N-acetylglucosamine transporter; DE AltName: Full=Golgi UDP-GlcNAc transporter; DE AltName: Full=Solute carrier family 35 member A3; GN Name=SLC35A3; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISEASE. RX PubMed=16344554; DOI=10.1101/gr.3690506; RA Thomsen B., Horn P., Panitz F., Bendixen E., Petersen A.H., Holm L.E., RA Nielsen V.H., Agerholm J.S., Arnbjerg J., Bendixen C.; RT "A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N- RT acetylglucosamine transporter, causes complex vertebral RT malformation."; RL Genome Res. 16:97-105(2006). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Hypothalamus; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) CC transporter in the Golgi apparatus. May supply UDP-GlcNAc as CC substrate for Golgi-resident glycosyltransferases that generate CC branching of diantennary oligosaccharides (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with SLC35A2. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; CC Multi-pass membrane protein {ECO:0000250}. CC -!- DISEASE: Note=Defects in SLC35A3 may be cause of complex vertebral CC malformation (CVM) in Holstein. {ECO:0000269|PubMed:16344554}. CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CC SLC35A subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY160683; AAO22138.1; -; Genomic_DNA. DR EMBL; BC153220; AAI53221.1; -; mRNA. DR RefSeq; NP_001098856.1; NM_001105386.1. DR RefSeq; XP_005204177.1; XM_005204120.2. DR RefSeq; XP_015319233.1; XM_015463747.1. DR UniGene; Bt.34192; -. DR STRING; 9913.ENSBTAP00000016519; -. DR PaxDb; Q6YC49; -. DR PRIDE; Q6YC49; -. DR Ensembl; ENSBTAT00000016519; ENSBTAP00000016519; ENSBTAG00000012454. DR GeneID; 520918; -. DR KEGG; bta:520918; -. DR CTD; 23443; -. DR VGNC; VGNC:49969; SLC35A3. DR eggNOG; KOG2234; Eukaryota. DR eggNOG; COG0697; LUCA. DR GeneTree; ENSGT00940000154054; -. DR HOGENOM; HOG000216649; -. DR HOVERGEN; HBG054025; -. DR InParanoid; Q6YC49; -. DR KO; K15272; -. DR OMA; VQWPSES; -. DR OrthoDB; EOG091G0CHS; -. DR TreeFam; TF315345; -. DR Reactome; R-BTA-727802; Transport of nucleotide sugars. DR Proteomes; UP000009136; Chromosome 3. DR Bgee; ENSBTAG00000012454; Expressed in 10 organ(s), highest expression level in colon. DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central. DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central. DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro. DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW. DR GO; GO:1990569; P:UDP-N-acetylglucosamine transmembrane transport; ISS:UniProtKB. DR InterPro; IPR007271; Nuc_sug_transpt. DR PANTHER; PTHR10231; PTHR10231; 1. DR Pfam; PF04142; Nuc_sug_transp; 1. DR PIRSF; PIRSF005799; UDP-gal_transpt; 1. PE 2: Evidence at transcript level; KW Complete proteome; Golgi apparatus; Membrane; Reference proteome; KW Sugar transport; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1 326 UDP-N-acetylglucosamine transporter. FT /FTId=PRO_0000213355. FT TRANSMEM 4 24 Helical. {ECO:0000255}. FT TRANSMEM 38 58 Helical. {ECO:0000255}. FT TRANSMEM 136 156 Helical. {ECO:0000255}. FT TRANSMEM 174 194 Helical. {ECO:0000255}. FT TRANSMEM 212 232 Helical. {ECO:0000255}. FT TRANSMEM 244 264 Helical. {ECO:0000255}. FT TRANSMEM 269 289 Helical. {ECO:0000255}. FT TRANSMEM 293 313 Helical. {ECO:0000255}. SQ SEQUENCE 326 AA; 36067 MW; 31F34B10BFB3DC37 CRC64; MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK DSKCSLRALN RILHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QELNSKELSA GSQFVGLMAV LTACFSSGFA GVYFEKILKE TKQSVWIRNI QLGFFGSIFG LMGVYVYDGE LVSKNGFFQG YNRLTWIVVV LQALGGLVIA AVIKYADNIL KGFATSLSII LSTLISYFWL QDFVPTSVFF LGAILVITAT FLYGYDPKPA GNPTKA //