ID S35A3_BOVIN Reviewed; 326 AA. AC Q6YC49; A7Z022; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 22-FEB-2012, entry version 57. DE RecName: Full=UDP-N-acetylglucosamine transporter; DE AltName: Full=Golgi UDP-GlcNAc transporter; DE AltName: Full=Solute carrier family 35 member A3; GN Name=SLC35A3; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Thomsen B., Horn P., Panitz F., Bendixen E., Petersen A.H., Holm L.E., RA Nielsen V.H., Agerholm J.S., Bendixen C.; RT "A missense mutation in SLC35A3, encoding an UDP-N-acetylglucosamine RT transporter, causes vertebral malformation in cattle."; RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Hypothalamus; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Uridine diphosphate-N-acetylglucosamine transporter in CC the Golgi apparatus (By similarity). CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass CC membrane protein (By similarity). CC -!- DISEASE: Note=Defects in SLC35A3 may be cause of complex vertebral CC malformation (CVM) in Holstein. CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CC SLC35A subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY160683; AAO22138.1; -; Genomic_DNA. DR EMBL; BC153220; AAI53221.1; -; mRNA. DR IPI; IPI00868658; -. DR RefSeq; NP_001098856.1; NM_001105386.1. DR UniGene; Bt.34192; -. DR PRIDE; Q6YC49; -. DR Ensembl; ENSBTAT00000016519; ENSBTAP00000016519; ENSBTAG00000012454. DR GeneID; 520918; -. DR KEGG; bta:520918; -. DR CTD; 23443; -. DR eggNOG; COG0697; -. DR GeneTree; ENSGT00550000074563; -. DR HOVERGEN; HBG054025; -. DR InParanoid; Q6YC49; -. DR KO; K15272; -. DR OrthoDB; EOG4V9TR3; -. DR PhylomeDB; Q6YC49; -. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005338; F:nucleotide-sugar transmembrane transporter activity; IEA:InterPro. DR GO; GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro. DR InterPro; IPR007271; Nuc_sug_transpt. DR InterPro; IPR021189; UDP/CMP-sugar_transptr. DR InterPro; IPR004689; UDPgal_transpt. DR PANTHER; PTHR10231; Nuc_sug_transpt; 1. DR Pfam; PF04142; Nuc_sug_transp; 1. DR PIRSF; PIRSF005799; UDP-gal_transpt; 1. DR TIGRFAMs; TIGR00803; Nst; 1. PE 2: Evidence at transcript level; KW Complete proteome; Golgi apparatus; Membrane; Reference proteome; KW Sugar transport; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1 326 UDP-N-acetylglucosamine transporter. FT /FTId=PRO_0000213355. FT TRANSMEM 4 24 Helical; (Potential). FT TRANSMEM 38 58 Helical; (Potential). FT TRANSMEM 136 156 Helical; (Potential). FT TRANSMEM 174 194 Helical; (Potential). FT TRANSMEM 212 232 Helical; (Potential). FT TRANSMEM 244 264 Helical; (Potential). FT TRANSMEM 269 289 Helical; (Potential). FT TRANSMEM 293 313 Helical; (Potential). SQ SEQUENCE 326 AA; 36067 MW; 31F34B10BFB3DC37 CRC64; MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK DSKCSLRALN RILHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QELNSKELSA GSQFVGLMAV LTACFSSGFA GVYFEKILKE TKQSVWIRNI QLGFFGSIFG LMGVYVYDGE LVSKNGFFQG YNRLTWIVVV LQALGGLVIA AVIKYADNIL KGFATSLSII LSTLISYFWL QDFVPTSVFF LGAILVITAT FLYGYDPKPA GNPTKA //