ID S35A3_BOVIN Reviewed; 326 AA. AC Q6YC49; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 12-JUN-2007, entry version 22. DE UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) DE (Solute carrier family 35 member A3). GN Name=SLC35A3; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Thomsen B., Horn P., Panitz F., Bendixen E., Petersen A.H., Holm L.E., RA Nielsen V.H., Agerholm J.S., Bendixen C.; RT "A missense mutation in SLC35A3, encoding an UDP-N-acetylglucosamine RT transporter, causes vertebral malformation in cattle."; RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Uridine diphosphate-N-acetylglucosamine transporter in CC the Golgi apparatus (By similarity). CC -!- SUBCELLULAR LOCATION: Golgi apparatus; Golgi apparatus membrane; CC multi-pass membrane protein (By similarity). CC -!- DISEASE: Defects in SLC35A3 may be cause of complex vertebral CC malformation (CVM) in Holstein. CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. CC SLC35A subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY160683; AAO22138.1; -; Genomic_DNA. DR UniGene; Bt.42208; -. DR Ensembl; ENSBTAG00000012454; Bos taurus. DR KEGG; bta:520918; -. DR InterPro; IPR007271; Nuc_sug_transpt. DR InterPro; IPR004689; UDPgal_transpt. DR PANTHER; PTHR10231; Nuc_sug_transpt; 1. DR Pfam; PF04142; Nuc_sug_transp; 1. DR TIGRFAMs; TIGR00803; nst; 1. KW Golgi apparatus; Membrane; Sugar transport; Transmembrane; Transport. FT CHAIN 1 326 UDP-N-acetylglucosamine transporter. FT /FTId=PRO_0000213355. FT TRANSMEM 4 24 Potential. FT TRANSMEM 38 58 Potential. FT TRANSMEM 136 156 Potential. FT TRANSMEM 174 194 Potential. FT TRANSMEM 212 232 Potential. FT TRANSMEM 244 264 Potential. FT TRANSMEM 269 289 Potential. FT TRANSMEM 293 313 Potential. SQ SEQUENCE 326 AA; 36067 MW; 31F34B10BFB3DC37 CRC64; MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK DSKCSLRALN RILHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QELNSKELSA GSQFVGLMAV LTACFSSGFA GVYFEKILKE TKQSVWIRNI QLGFFGSIFG LMGVYVYDGE LVSKNGFFQG YNRLTWIVVV LQALGGLVIA AVIKYADNIL KGFATSLSII LSTLISYFWL QDFVPTSVFF LGAILVITAT FLYGYDPKPA GNPTKA //