ID S35A3_BOVIN Reviewed; 326 AA. AC Q6YC49; A7Z022; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 17-JUN-2020, entry version 106. DE RecName: Full=UDP-N-acetylglucosamine transporter; DE AltName: Full=Golgi UDP-GlcNAc transporter; DE AltName: Full=Solute carrier family 35 member A3; GN Name=SLC35A3; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISEASE. RX PubMed=16344554; DOI=10.1101/gr.3690506; RA Thomsen B., Horn P., Panitz F., Bendixen E., Petersen A.H., Holm L.E., RA Nielsen V.H., Agerholm J.S., Arnbjerg J., Bendixen C.; RT "A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N- RT acetylglucosamine transporter, causes complex vertebral malformation."; RL Genome Res. 16:97-105(2006). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Hypothalamus; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) CC transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate CC for Golgi-resident glycosyltransferases that generate branching of CC diantennary oligosaccharides (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Interacts with SLC35A2. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi- CC pass membrane protein {ECO:0000250}. CC -!- DISEASE: Note=Defects in SLC35A3 may be cause of complex vertebral CC malformation (CVM) in Holstein. {ECO:0000269|PubMed:16344554}. CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY160683; AAO22138.1; -; Genomic_DNA. DR EMBL; BC153220; AAI53221.1; -; mRNA. DR RefSeq; NP_001098856.1; NM_001105386.1. DR RefSeq; XP_005204177.1; XM_005204120.2. DR RefSeq; XP_015319233.1; XM_015463747.1. DR SMR; Q6YC49; -. DR STRING; 9913.ENSBTAP00000016519; -. DR PaxDb; Q6YC49; -. DR PRIDE; Q6YC49; -. DR Ensembl; ENSBTAT00000016519; ENSBTAP00000016519; ENSBTAG00000012454. DR Ensembl; ENSBTAT00000076918; ENSBTAP00000063794; ENSBTAG00000012454. DR GeneID; 520918; -. DR KEGG; bta:520918; -. DR CTD; 23443; -. DR VGNC; VGNC:49969; SLC35A3. DR eggNOG; KOG2234; Eukaryota. DR eggNOG; COG0697; LUCA. DR GeneTree; ENSGT00950000182827; -. DR HOGENOM; CLU_024645_1_0_1; -. DR InParanoid; Q6YC49; -. DR KO; K15272; -. DR OMA; SKCNLRT; -. DR OrthoDB; 703674at2759; -. DR TreeFam; TF315345; -. DR Reactome; R-BTA-727802; Transport of nucleotide sugars. DR Proteomes; UP000009136; Chromosome 3. DR Bgee; ENSBTAG00000012454; Expressed in colon and 9 other tissues. DR ExpressionAtlas; Q6YC49; baseline. DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central. DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central. DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW. DR GO; GO:1990569; P:UDP-N-acetylglucosamine transmembrane transport; ISS:UniProtKB. DR InterPro; IPR007271; Nuc_sug_transpt. DR PANTHER; PTHR10231; PTHR10231; 1. DR Pfam; PF04142; Nuc_sug_transp; 1. DR PIRSF; PIRSF005799; UDP-gal_transpt; 1. PE 2: Evidence at transcript level; KW Golgi apparatus; Membrane; Reference proteome; Sugar transport; KW Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..326 FT /note="UDP-N-acetylglucosamine transporter" FT /id="PRO_0000213355" FT TRANSMEM 4..24 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 38..58 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 136..156 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 174..194 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 212..232 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 244..264 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 269..289 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 293..313 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 326 AA; 36067 MW; 31F34B10BFB3DC37 CRC64; MSANLKYLSL GILVFQTTSL VLTMRYSRTL KEEGPRYLSS TAVVVAELLK IMACILLVYK DSKCSLRALN RILHDEILNK PMETLKLAIP SGIYTLQNNL LYVALSNLDA ATYQVTYQLK ILTTALFSVS MLSKKLGVYQ WLSLVILMTG VAFVQWPSDS QELNSKELSA GSQFVGLMAV LTACFSSGFA GVYFEKILKE TKQSVWIRNI QLGFFGSIFG LMGVYVYDGE LVSKNGFFQG YNRLTWIVVV LQALGGLVIA AVIKYADNIL KGFATSLSII LSTLISYFWL QDFVPTSVFF LGAILVITAT FLYGYDPKPA GNPTKA //