ID Q6WNT3_TAKRU Unreviewed; 408 AA. AC Q6WNT3; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JUL-2024, entry version 89. DE RecName: Full=Transcription factor SOX {ECO:0000256|PIRNR:PIRNR038098}; GN Name=Sox12 {ECO:0000313|EMBL:AAQ18503.1}; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu. OX NCBI_TaxID=31033 {ECO:0000313|EMBL:AAQ18503.1}; RN [1] {ECO:0000313|EMBL:AAQ18503.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15019997; DOI=10.1016/j.gene.2003.12.008; RA Koopman P., Schepers G., Brenner S., Venkatesh B.; RT "Origin and diversity of the SOX transcription factor gene family: genome- RT wide analysis in Fugu rubripes."; RL Gene 328:177-186(2004). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038098}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY277960; AAQ18503.1; -; Genomic_DNA. DR RefSeq; XP_011603774.1; XM_011605472.1. DR AlphaFoldDB; Q6WNT3; -. DR STRING; 31033.ENSTRUP00000053530; -. DR GeneID; 101072693; -. DR KEGG; tru:101072693; -. DR CTD; 393875; -. DR OrthoDB; 2902801at2759; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:TreeGrafter. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter. DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:TreeGrafter. DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter. DR CDD; cd22038; HMG-box_SoxC_SOX12; 1. DR Gene3D; 1.10.30.10; High mobility group box domain; 1. DR InterPro; IPR009071; HMG_box_dom. DR InterPro; IPR036910; HMG_box_dom_sf. DR InterPro; IPR017386; SOX-12/11/4. DR InterPro; IPR050140; SRY-related_HMG-box_TFs. DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1. DR PANTHER; PTHR10270:SF27; TRANSCRIPTION FACTOR SOX-4; 1. DR Pfam; PF00505; HMG_box; 1. DR PIRSF; PIRSF038098; SOX-12/11/4a; 1. DR SMART; SM00398; HMG; 1. DR SUPFAM; SSF47095; HMG-box; 1. DR PROSITE; PS50118; HMG_BOX_2; 1. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR038098}; KW Nucleus {ECO:0000256|PIRNR:PIRNR038098, ECO:0000256|PROSITE- KW ProRule:PRU00267}; Transcription {ECO:0000256|PIRNR:PIRNR038098}; KW Transcription regulation {ECO:0000256|PIRNR:PIRNR038098}. FT DOMAIN 67..135 FT /note="HMG box" FT /evidence="ECO:0000259|PROSITE:PS50118" FT DNA_BIND 67..135 FT /note="HMG box" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267" FT REGION 29..56 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 136..354 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 145..225 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 243..272 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 288..332 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 408 AA; 43521 MW; 3CFF40AB77294E64 CRC64; MVQKTSHTES TAEALSFFAV DSSSDSGTCM DLDPAASPLS PGSTASSTAG DKLAEDPAWC KTPSGHIKRP MNAFMVWSQI ERRKIMEQSP DMHNAEISKR LGKRWKLLRD SDKIPFIKEA ERLRLKHMAD YPDYKYRPRK KVKSSASKPG SSGEKGEKLH SSSINTSTKT SSSSRKNGPK SPSSSKPHKS LFGSSSSTKA SPFASEHQSE HHNSLYKSKS VSSAAKQIPD GKKPKRMYVY GSSAANLSVS PASSVVVPAS PTLSSSADSS DPLSLYEDAG SGREDGAESP GSSGSQGGSS VRQGGHTYSS RRASSPTPSG SHSSASSHSS SSSSEDEEFE DINPSPSFDS MSLGSFGSSV LDRDLDLNFE SGSGGSHFEF PDYCTPEVSE MISGDWLEST ISNLVFTY //