ID Q6VHV2_HUMAN Unreviewed; 513 AA. AC Q6VHV2; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 08-FEB-2011, entry version 53. DE SubName: Full=Cytochrome c oxidase subunit I; GN Name=COX1; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=F164; RX MEDLINE=21313109; PubMed=11349229; DOI=10.1086/320591; RA Finnila S., Lehtonen M.S., Majamaa K.; RT "Phylogenetic network for European mtDNA."; RL Am. J. Hum. Genet. 68:1475-1484(2001). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=F164; RX PubMed=12949126; DOI=10.1093/molbev/msg230; RA Moilanen J.S., Finnila S., Majamaa K.; RT "Lineage-specific selection in human mtDNA: lack of polymorphisms in a RT segment of MTND5 gene in haplogroup J."; RL Mol. Biol. Evol. 20:2132-2142(2003). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=F164; RA Moilanen J.S., Finnila S., Lehtonen M.S., Majamaa K.; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=39_M1a5; RX PubMed=17170302; DOI=10.1126/science.1135566; RA Olivieri A., Achilli A., pala M., Battaglia V., Fornarino S., RA Al-Zahery N., Scozzari R., Cruciani F., Behar D.M., Dugoujon J.-M., RA Coudray C., Santachiara-Benerecetti A.S., Semino O., Bandelt H.-J., RA Torroni A.; RT "The mtDNA legacy of the Levantine early Upper Palaeolithic in RT Africa."; RL Science 314:1767-1770(2006). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Am012, and AM038; RX PubMed=18359946; DOI=10.1093/molbev/msn068; RA Soares P., Trejaut J.A., Loo J.H., Hill C., Mormina M., Lee C.L., RA Chen Y.M., Hudjashov G., Forster P., Macaulay V., Bulbeck D., RA Oppenheimer S., Lin M., Richards M.B.; RT "Climate change and postglacial human dispersals in southeast Asia."; RL Mol. Biol. Evol. 25:1209-1218(2008). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MTDNA361; RX MEDLINE=21947462; PubMed=11938495; DOI=10.1086/339933; RA Herrnstadt C., Elson J.L., Fahy E., Preston G., Turnbull D.M., RA Anderson C., Ghosh S.S., Olefsky J.M., Beal M.F., Davis R.E., RA Howell N.; RT "Reduced-median-network analysis of complete mitochondrial DNA coding- RT region sequences for the major African, Asian, and European RT haplogroups."; RL Am. J. Hum. Genet. 70:1152-1171(2002). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MTDNA361; RA Herrnstadt C., Fahy E., Preston G., Anderson C., Ghosh S.S., RA Davis R.E., Howell N.; RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MTDNA361; RG HmtDB; RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=KD20, KD27, KD10, KD23, and KR30; RX PubMed=19624810; DOI=10.1186/1471-2148-9-173; RA Kumar S., Ravuri R.R., Koneru P., Urade B.P., Sarkar B.N., RA Chandrasekar A., Rao V.R.; RT "Reconstructing Indian-Australian phylogenetic link."; RL BMC Evol. Biol. 9:173-173(2009). RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=KD20, KD27, KD10, KD23, and KR30; RX PubMed=19823670; DOI=10.1371/journal.pone.0007447; RA Chandrasekar A., Kumar S., Sreenath J., Sarkar B.N., Urade B.P., RA Mallick S., Bandopadhyay S.S., Barua P., Barik S.S., Basu D., RA Kiran U., Gangopadhyay P., Sahani R., Prasad B.V., Gangopadhyay S., RA Lakshmi G.R., Ravuri R.R., Padmaja K., Venugopal P.N., Sharma M.B., RA Rao V.R.; RT "Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: RT dispersal of modern human in South Asian corridor."; RL PLoS ONE 4:E7447-E7447(2009). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bargut_Bt105; RA Derenko M., Malyarchuk B., Grzybowski T.; RT "Phylogeny of North Asian mitochondrial haplogroups C and D."; RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE. RA Greenspan B.; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY339565; AAP91157.1; -; Genomic_DNA. DR EMBL; EF060350; ABJ89449.1; -; Genomic_DNA. DR EMBL; EF093535; ABL61582.1; -; Genomic_DNA. DR EMBL; EF093536; ABL61595.1; -; Genomic_DNA. DR EMBL; EF657522; ABR96749.1; -; Genomic_DNA. DR EMBL; FJ383536; ACM74096.1; -; Genomic_DNA. DR EMBL; FJ383537; ACM74109.1; -; Genomic_DNA. DR EMBL; FJ383538; ACM74122.1; -; Genomic_DNA. DR EMBL; FJ383539; ACM74135.1; -; Genomic_DNA. DR EMBL; FJ383540; ACM74148.1; -; Genomic_DNA. DR EMBL; FJ951544; ACQ75285.1; -; Genomic_DNA. DR EMBL; HM775494; ADK47863.1; -; Genomic_DNA. DR IPI; IPI00464968; -. DR HSSP; P98002; 1AR1. DR ProteinModelPortal; Q6VHV2; -. DR SMR; Q6VHV2; 1-511. DR STRING; Q6VHV2; -. DR Ensembl; ENST00000361624; ENSP00000354499; ENSG00000198804. DR HGNC; HGNC:7419; MT-CO1. DR HOVERGEN; HBG003841; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR InterPro; IPR000883; Cyt_c_oxidase_su1. DR Gene3D; G3DSA:1.20.210.10; COX1; 1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; COX1; 1. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. PE 4: Predicted; KW Mitochondrion. SQ SEQUENCE 513 AA; 57053 MW; D08B485E89A3A1F1 CRC64; MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVEA GAGTGWTVYP PLAGNYSHPG ASVDLIIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS //