ID   CLM5_HUMAN              Reviewed;         194 AA.
AC   Q6UXZ3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   02-OCT-2024, entry version 146.
DE   RecName: Full=CMRF35-like molecule 5 {ECO:0000250|UniProtKB:Q8VCH2};
DE            Short=CLM-5 {ECO:0000250|UniProtKB:Q8VCH2};
DE   AltName: Full=CD300 antigen-like family member D;
DE   AltName: Full=CMRF35-A4;
DE   AltName: CD_antigen=CD300d;
DE   Flags: Precursor;
GN   Name=CD300LD;
GN   Synonyms=CD300D {ECO:0000303|PubMed:22291008, ECO:0000303|Ref.1},
GN   CMRF35A4 {ECO:0000303|PubMed:12483297}; ORFNames=UNQ9218/PRO28686;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Martinez-Barriocanal A., Sayos J.;
RT   "Molecular and functional characterization of human CD300d, a novel
RT   receptor expressed by myeloid cells.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, SUBUNIT, TISSUE
RP   SPECIFICITY, GLYCOSYLATION, AND MUTAGENESIS OF ARG-158.
RC   TISSUE=Peripheral blood monocyte;
RX   PubMed=22291008; DOI=10.1074/jbc.m111.279224;
RA   Comas-Casellas E., Martinez-Barriocanal A., Miro F., Ejarque-Ortiz A.,
RA   Schwartz S. Jr., Martin M., Sayos J.;
RT   "Cloning and characterization of CD300d, a novel member of the human CD300
RT   family of immune receptors.";
RL   J. Biol. Chem. 287:9682-9693(2012).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=12483297; DOI=10.1007/s00439-002-0851-y;
RA   Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L.,
RA   Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.;
RT   "Novel immunoglobulin superfamily gene cluster, mapping to a region of
RT   human chromosome 17q25, linked to psoriasis susceptibility.";
RL   Hum. Genet. 112:34-41(2003).
CC   -!- SUBUNIT: Forms complexes with the CD300 family members with exception
CC       of CD300c. {ECO:0000269|PubMed:22291008}.
CC   -!- INTERACTION:
CC       Q6UXZ3; A8K4G0: CD300LB; NbExp=2; IntAct=EBI-4314468, EBI-26499879;
CC       Q6UXZ3; P04155: TFF1; NbExp=3; IntAct=EBI-4314468, EBI-743871;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22291008};
CC       Single-pass type I membrane protein {ECO:0000269|PubMed:22291008}.
CC       Note=Cell surface localization requires the ITAM-bearing Fc receptor
CC       FCER1G to overcome ER retention.
CC   -!- TISSUE SPECIFICITY: Expression seems restricted to cells of myeloid
CC       lineage. {ECO:0000269|PubMed:22291008}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:22291008}.
CC   -!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
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DR   EMBL; EF137868; ABM30606.1; -; mRNA.
DR   EMBL; AY358148; AAQ88515.1; -; mRNA.
DR   CCDS; CCDS42379.1; -.
DR   RefSeq; NP_001108624.1; NM_001115152.1.
DR   AlphaFoldDB; Q6UXZ3; -.
DR   SMR; Q6UXZ3; -.
DR   BioGRID; 137769; 2.
DR   IntAct; Q6UXZ3; 8.
DR   STRING; 9606.ENSP00000364501; -.
DR   GlyCosmos; Q6UXZ3; 1 site, No reported glycans.
DR   GlyGen; Q6UXZ3; 1 site.
DR   iPTMnet; Q6UXZ3; -.
DR   PhosphoSitePlus; Q6UXZ3; -.
DR   BioMuta; CD300LD; -.
DR   DMDM; 74758584; -.
DR   jPOST; Q6UXZ3; -.
DR   MassIVE; Q6UXZ3; -.
DR   PaxDb; 9606-ENSP00000364501; -.
DR   PeptideAtlas; Q6UXZ3; -.
DR   Antibodypedia; 31991; 39 antibodies from 16 providers.
DR   DNASU; 100131439; -.
DR   Ensembl; ENST00000375352.1; ENSP00000364501.1; ENSG00000204345.1.
DR   Ensembl; ENST00000709212.1; ENSP00000517559.1; ENSG00000291922.1.
DR   GeneID; 100131439; -.
DR   KEGG; hsa:100131439; -.
DR   MANE-Select; ENST00000375352.1; ENSP00000364501.1; NM_001115152.2; NP_001108624.1.
DR   UCSC; uc002jkz.3; human.
DR   AGR; HGNC:16848; -.
DR   CTD; 100131439; -.
DR   GeneCards; CD300LD; -.
DR   HGNC; HGNC:16848; CD300LD.
DR   HPA; ENSG00000204345; Not detected.
DR   MIM; 616301; gene.
DR   neXtProt; NX_Q6UXZ3; -.
DR   OpenTargets; ENSG00000204345; -.
DR   PharmGKB; PA162382124; -.
DR   VEuPathDB; HostDB:ENSG00000204345; -.
DR   eggNOG; ENOG502SU7J; Eukaryota.
DR   GeneTree; ENSGT00940000164782; -.
DR   HOGENOM; CLU_051023_3_1_1; -.
DR   InParanoid; Q6UXZ3; -.
DR   OMA; DWNYCNI; -.
DR   OrthoDB; 4204212at2759; -.
DR   PhylomeDB; Q6UXZ3; -.
DR   TreeFam; TF334441; -.
DR   PathwayCommons; Q6UXZ3; -.
DR   Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   SignaLink; Q6UXZ3; -.
DR   BioGRID-ORCS; 100131439; 13 hits in 1149 CRISPR screens.
DR   GenomeRNAi; 100131439; -.
DR   Pharos; Q6UXZ3; Tdark.
DR   PRO; PR:Q6UXZ3; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q6UXZ3; protein.
DR   Bgee; ENSG00000204345; Expressed in blood and 8 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR   CDD; cd05716; IgV_pIgR_like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR050671; CD300_family_receptors.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR11860:SF108; CMRF35-LIKE MOLECULE 5; 1.
DR   PANTHER; PTHR11860; POLYMERIC-IMMUNOGLOBULIN RECEPTOR; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW   Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..194
FT                   /note="CMRF35-like molecule 5"
FT                   /id="PRO_0000320126"
FT   TOPO_DOM        19..165
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..194
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          19..125
FT                   /note="Ig-like V-type"
FT   CARBOHYD        28
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        39..107
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VARIANT         6
FT                   /note="S -> A (in dbSNP:rs493430)"
FT                   /id="VAR_059386"
FT   VARIANT         89
FT                   /note="V -> M (in dbSNP:rs783239)"
FT                   /id="VAR_059387"
FT   MUTAGEN         158
FT                   /note="R->S: Unable to reach the cell surface upon
FT                   transfection."
FT                   /evidence="ECO:0000269|PubMed:22291008"
SQ   SEQUENCE   194 AA;  21558 MW;  5E3A4CB03B473E12 CRC64;
     MWLSPSLLLL ILPGYSIAAK ITGPTTVNGS EQGSLTVQCA YGSGWETYLK WRCQGADWNY
     CNILVKTNGS EQEVKKNRVS IRDNQKNHVF TVTMENLKRD DADSYWCGTE RPGIDLGVKV
     QVTINPGTQT AVSEWTTTTA SLAFTAAATQ KTSSPLTRSP LKSTHFLFLF LLELPLLLSM
     LGTVLWVNRP QRRS
//