ID IG2AS_HUMAN Reviewed; 168 AA. AC Q6U949; A5PKV8; A6NNQ2; Q7Z712; Q9P2W0; DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot. DT 20-FEB-2007, sequence version 2. DT 14-DEC-2022, entry version 98. DE RecName: Full=Putative insulin-like growth factor 2 antisense gene protein; DE AltName: Full=IGF2 antisense RNA 1; DE AltName: Full=IGF2 antisense gene protein 1; DE AltName: Full=PEG8/IGF2AS protein; DE AltName: Full=Putative insulin-like growth factor 2 antisense gene protein 1; DE Short=IGF2-AS1; GN Name=IGF2-AS; Synonyms=IGF2-AS1, IGF2AS; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-125 AND ALA-150. RC TISSUE=Kidney; RX PubMed=10731720; DOI=10.1093/oxfordjournals.jbchem.a022630; RA Okutsu T., Kuroiwa Y., Kagitani F., Kai M., Aisaka K., Tsutsumi O., RA Kaneko Y., Yokomori K., Surani M.A., Kohda T., Kaneko-Ishino T., Ishino F.; RT "Expression and imprinting status of human PEG8/IGF2AS, a paternally RT expressed antisense transcript from the IGF2 locus, in Wilms' tumors."; RL J. Biochem. 127:475-483(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-125 AND ALA-150. RX PubMed=12702581; RA Vu T.H., Chuyen N.V., Li T., Hoffman A.R.; RT "Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' RT tumor."; RL Cancer Res. 63:1900-1905(2003). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-106; THR-112; VAL-125 RP AND ALA-150. RG SeattleSNPs variation discovery resource; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- DEVELOPMENTAL STAGE: Overexpressed in Wilms' tumor samples. CC -!- SEQUENCE CAUTION: CC Sequence=BAA90470.1; Type=Frameshift; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=SeattleSNPs; CC URL="http://pga.gs.washington.edu/data/igf2as/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB030733; BAA90470.1; ALT_FRAME; mRNA. DR EMBL; AY149295; AAP50262.1; -; mRNA. DR EMBL; AY375532; AAQ86595.1; -; Genomic_DNA. DR EMBL; AC132217; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC142634; AAI42635.1; -; mRNA. DR EMBL; BC142691; AAI42692.1; -; mRNA. DR PIR; JC7217; JC7217. DR AlphaFoldDB; Q6U949; -. DR BioMuta; HGNC:14062; -. DR DMDM; 126302557; -. DR MassIVE; Q6U949; -. DR PeptideAtlas; Q6U949; -. DR ProteomicsDB; 67400; -. DR AGR; HGNC:14062; -. DR GeneCards; IGF2-AS; -. DR HGNC; HGNC:14062; IGF2-AS. DR MIM; 610146; gene. DR neXtProt; NX_Q6U949; -. DR InParanoid; Q6U949; -. DR PhylomeDB; Q6U949; -. DR TreeFam; TF341861; -. DR PathwayCommons; Q6U949; -. DR Pharos; Q6U949; Tdark. DR PRO; PR:Q6U949; -. DR Proteomes; UP000005640; Unplaced. DR RNAct; Q6U949; protein. PE 2: Evidence at transcript level; KW Reference proteome. FT CHAIN 1..168 FT /note="Putative insulin-like growth factor 2 antisense gene FT protein" FT /id="PRO_0000076224" FT REGION 1..91 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 108..168 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 106 FT /note="S -> I (in dbSNP:rs17883406)" FT /evidence="ECO:0000269|Ref.3" FT /id="VAR_024844" FT VARIANT 112 FT /note="P -> T (in dbSNP:rs17883142)" FT /evidence="ECO:0000269|Ref.3" FT /id="VAR_024845" FT VARIANT 125 FT /note="F -> V (in dbSNP:rs1003483)" FT /evidence="ECO:0000269|PubMed:10731720, FT ECO:0000269|PubMed:12702581, ECO:0000269|Ref.3" FT /id="VAR_024846" FT VARIANT 150 FT /note="T -> A (in dbSNP:rs1003484)" FT /evidence="ECO:0000269|PubMed:10731720, FT ECO:0000269|PubMed:12702581, ECO:0000269|Ref.3" FT /id="VAR_024847" FT CONFLICT 163 FT /note="P -> T (in Ref. 1; BAA90470)" FT /evidence="ECO:0000305" SQ SEQUENCE 168 AA; 18035 MW; 4641D52BCBFE64D2 CRC64; MSKRKWRGFR GAQQERAQPP AASPQPCPAP HAGLPGGSRR RAPAPAGQQQ MRAESRSGAQ RRRGSARRGA HREAGGCVRG RTRSSGSERS NALWQAVDAA EALALSSPLR RPWDQAQHFT NPAPFSKGPQ SAPPSPPAGR RRRGADLALT PLAGEGHTRW RQPGRPGK //