ID   Q6U2F0_HUMAN            Unreviewed;       534 AA.
AC   Q6U2F0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   03-NOV-2009, entry version 34.
DE   SubName: Full=C4A2;
DE   SubName: Full=C4A3;
DE   Flags: Fragment;
GN   Name=C4A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=35.2C4A2, and 35.2C4A3;
RA   Sayer D., Puschendorf M., Wetherall J.;
RT   "Molecular genetics of complement C4: implications for MHC evolution
RT   and disease susceptibility gene mapping.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY379934; AAR89161.1; -; Genomic_DNA.
DR   EMBL; AY379935; AAR89162.1; -; Genomic_DNA.
DR   IPI; IPI00889723; -.
DR   UniGene; Hs.714747; -.
DR   HSSP; P01031; 1KJS.
DR   SMR; Q6U2F0; 305-534.
DR   STRING; Q6U2F0; -.
DR   Ensembl; ENST00000375295; ENSP00000364444; ENSG00000244207; Homo sapiens.
DR   Ensembl; ENST00000383324; ENSP00000372814; ENSG00000227746; Homo sapiens.
DR   Ensembl; ENST00000421274; ENSP00000388662; ENSG00000227746; Homo sapiens.
DR   Ensembl; ENST00000428956; ENSP00000396688; ENSG00000244731; Homo sapiens.
DR   Ensembl; ENST00000442246; ENSP00000403960; ENSG00000244731; Homo sapiens.
DR   Ensembl; ENST00000498271; ENSP00000420212; ENSG00000244731; Homo sapiens.
DR   HOVERGEN; Q6U2F0; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006956; P:complement activation; IEA:InterPro.
DR   InterPro; IPR011626; A2M_comp.
DR   InterPro; IPR000020; Anaphylatoxin/fibulin.
DR   InterPro; IPR018081; Anaphylatoxin_.
DR   InterPro; IPR001840; Anaphylatoxn.
DR   InterPro; IPR001599; MacrogloblnA2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR019565; MacrogloblnA2_thiol-ester-bond.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Gene3D; G3DSA:1.20.91.20; Anaphylatoxin; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07678; A2M_comp; 1.
DR   Pfam; PF01821; ANATO; 1.
DR   Pfam; PF10569; Thiol-ester_cl; 1.
DR   PRINTS; PR00004; ANAPHYLATOXN.
DR   ProDom; PD003264; Anaphylatoxin; 1.
DR   SMART; SM00104; ANATO; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR   PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR   PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
PE   4: Predicted;
FT   NON_TER       1      1
FT   NON_TER     534    534
SQ   SEQUENCE   534 AA;  58430 MW;  A189D07ECD2A894C CRC64;
     GQYASPTAKR CCQDGVTRLP MMRSCEQRAA RVQQPDCREP FLSCCQFAES LRKKSRDKGQ
     AGLQRALEIL QEEDLIDEDD IPVRSFFPEN WLWRVETVDR FQILTLWLPD SLTTWEIHGL
     SLSKTKGLCV ATPVQLRVFR EFHLHLRLPM SVRRFEQLEL RPVLYNYLDK NLTVSVHVSP
     VEGLCLAGGG GLAQQVLVPA GSARPVAFSV VPTAAAAVSL KVVARGSFEF PVGDAVSKVL
     QIEKEGAIHR EELVYELNPL DHRGRTLEIP GNSDPNMIPD GDFNSYVRVT ASDPLDTLGS
     EGALSPGGVA SLLRLPRGCG EQTMIYLAPT LAASRYLDKT EQWSTLPPET KDHAVDLIQK
     GYMRIQQFRK ADGSYAAWLS RDSSTWLTAF VLKVLSLAQE QVGGSPEKLQ ETSNWLLSQQ
     QADGSFQDPC PVLDRSMQGG LVGNDETVAL TAFVTIALHH GLAVFQDEGA EPLKQRVEAS
     ISKANSFLGE KASAGLLGAH AAAITAYALT LTKAPVDLLG VAHNNLMAMA QETG
//