ID Q6TNQ8_DANRE Unreviewed; 565 AA. AC Q6TNQ8; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 10-FEB-2021, entry version 103. DE RecName: Full=Branchpoint-bridging protein {ECO:0000256|RuleBase:RU910722}; GN Name=sf1 {ECO:0000313|ZFIN:ZDB-GENE-030131-2492}; GN Synonyms=SF1 {ECO:0000313|EMBL:AAQ91271.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAQ91271.1}; RN [1] {ECO:0000313|EMBL:AAQ91271.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15520368; DOI=10.1073/pnas.0407241101; RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., RA Look A.T., Chen Z.; RT "Hematopoietic gene expression profile in zebrafish kidney marrow."; RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004). CC -!- FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the CC recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract CC and the 3'-splice site at the 3'-end of introns. CC {ECO:0000256|RuleBase:RU910722}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|RuleBase:RU910722}. CC -!- SIMILARITY: Belongs to the BBP/SF1 family. CC {ECO:0000256|ARBA:ARBA00010382, ECO:0000256|RuleBase:RU910722}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY391459; AAQ91271.1; -; mRNA. DR RefSeq; NP_997818.1; NM_212653.1. DR GeneID; 572785; -. DR KEGG; dre:572785; -. DR CTD; 7536; -. DR ZFIN; ZDB-GENE-030131-2492; sf1. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central. DR GO; GO:0045131; F:pre-mRNA branch point binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro. DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central. DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN. DR Gene3D; 3.30.1370.10; -; 1. DR InterPro; IPR031150; BBP/SF1. DR InterPro; IPR004087; KH_dom. DR InterPro; IPR004088; KH_dom_type_1. DR InterPro; IPR036612; KH_dom_type_1_sf. DR InterPro; IPR032570; SF1-HH. DR InterPro; IPR001878; Znf_CCHC. DR PANTHER; PTHR11208:SF45; PTHR11208:SF45; 1. DR Pfam; PF00013; KH_1; 1. DR Pfam; PF16275; SF1-HH; 1. DR Pfam; PF00098; zf-CCHC; 1. DR SMART; SM00322; KH; 1. DR SMART; SM00343; ZnF_C2HC; 1. DR SUPFAM; SSF54791; SSF54791; 1. DR PROSITE; PS50158; ZF_CCHC; 1. PE 2: Evidence at transcript level; KW Metal-binding {ECO:0000256|RuleBase:RU910722}; KW mRNA processing {ECO:0000256|ARBA:ARBA00022664, KW ECO:0000256|RuleBase:RU910722}; KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187, KW ECO:0000256|RuleBase:RU910722}; Nucleus {ECO:0000256|RuleBase:RU910722}; KW Spliceosome {ECO:0000256|RuleBase:RU910722}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU910722}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00047, ECO:0000256|RuleBase:RU910722}. FT DOMAIN 279..293 FT /note="CCHC-type" FT /evidence="ECO:0000259|PROSITE:PS50158" FT REGION 1..44 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 69..90 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 328..565 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 344..364 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 383..449 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 450..482 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 483..540 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 549..565 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 565 AA; 61143 MW; DB0B14DB70AB6061 CRC64; MATGANATPL DFGQKKRKRS RWSSETPDQK TVIPGMPTVI PPGLTRDQER AYIVQLQIED LTRKLRTGDL GIPVNPEDRS PSPEPIYNSE GKRLNTREYR TRKKLEEERH SLITEMVGLN PEFKPPTDYK PPATRVSDKV MIPQDEYPEI NFVGLLIGPR GNTLKNIEKE CCAKIMIRGK GSVKEGKVGR KDGQMLPGED EPLHALVTAN TMENVKKAVE QIRYILKQGI ETPEDQNDLR KMQLRELARL NGTLREDDNR ILRPWQSTEP RSITNTTLCT KCGGAGHISS DCKFTSSFAP RPGEPPQSAQ DKARMDKEYL SLMAELGEAP VPSSGGGHNN APPSGPRPSG PNNNQPPPNR PPWMNSGPTD NRNFHGMHQG PGGPHNFPPP MPNMGGPPMP PNPNGMPPPW MQPPPPPMGQ GPAPPGHPMG PLPPWQQQAP PPPPTSSMAT SAPMPWQQNT TTTSTPATGN LPPWQQPQQT AASASQPPPP MGNPSMVPPP PGVQPPLPPG APPPPPPPPP GSAGMMYAPP PPPPPMDPNF VTMMGIPGMP PYGMPPAPPP PPPQS //