ID THA11_DANRE Reviewed; 257 AA. AC Q6TGZ4; Q6NYT2; DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot. DT 25-NOV-2008, sequence version 2. DT 24-JAN-2024, entry version 92. DE RecName: Full=THAP domain-containing protein 11; GN Name=thap11; ORFNames=zgc:65871; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Kidney marrow; RX PubMed=15520368; DOI=10.1073/pnas.0407241101; RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., RA Look A.T., Chen Z.; RT "Hematopoietic gene expression profile in zebrafish kidney marrow."; RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Embryo; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Transcriptional repressor that plays a central role for CC embryogenesis and the pluripotency of embryonic stem (ES) cells. CC Sequence-specific DNA-binding factor that represses gene expression in CC pluripotent ES cells by directly binding to key genetic loci and CC recruiting epigenetic modifiers (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q6TGZ4-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6TGZ4-2; Sequence=VSP_035879; CC -!- SIMILARITY: Belongs to the THAP11 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY398362; AAQ97795.1; -; mRNA. DR EMBL; BC056572; AAH56572.1; -; mRNA. DR EMBL; BC066471; AAH66471.1; -; mRNA. DR RefSeq; NP_998267.1; NM_213102.1. [Q6TGZ4-1] DR AlphaFoldDB; Q6TGZ4; -. DR SMR; Q6TGZ4; -. DR STRING; 7955.ENSDARP00000052341; -. DR PaxDb; 7955-ENSDARP00000052341; -. DR GeneID; 406390; -. DR KEGG; dre:406390; -. DR CTD; 57215; -. DR ZFIN; ZDB-GENE-040426-2121; thap11. DR eggNOG; ENOG502QQ1Z; Eukaryota. DR HOGENOM; CLU_090879_1_0_1; -. DR InParanoid; Q6TGZ4; -. DR OMA; NERKAQR; -. DR OrthoDB; 4229223at2759; -. DR PhylomeDB; Q6TGZ4; -. DR TreeFam; TF331359; -. DR PRO; PR:Q6TGZ4; -. DR Proteomes; UP000000437; Chromosome 7. DR Bgee; ENSDARG00000036055; Expressed in ovary and 28 other cell types or tissues. DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd22291; cc_THAP11_C; 1. DR InterPro; IPR006612; THAP_Znf. DR PANTHER; PTHR22794; THAP DOMAIN PROTEIN 11; 1. DR PANTHER; PTHR22794:SF2; THAP DOMAIN-CONTAINING PROTEIN 11; 1. DR Pfam; PF05485; THAP; 1. DR SMART; SM00692; DM3; 1. DR SMART; SM00980; THAP; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR PROSITE; PS50950; ZF_THAP; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Coiled coil; DNA-binding; Metal-binding; Nucleus; KW Reference proteome; Repressor; Transcription; Transcription regulation; KW Zinc; Zinc-finger. FT CHAIN 1..257 FT /note="THAP domain-containing protein 11" FT /id="PRO_0000355149" FT ZN_FING 6..64 FT /note="THAP-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309" FT COILED 196..251 FT /evidence="ECO:0000255" FT VAR_SEQ 134..136 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15520368" FT /id="VSP_035879" SQ SEQUENCE 257 AA; 28728 MW; 7E464599E8687975 CRC64; MPGFTCCVPG CYNNSHRDRD LRFYTFPKDP TQREIWLKNI SRAGVSGCFS TFQPTTGHRV CSVHFPGGRK TYTIRVPTLF PLRGVNERRS RRGRSRKVSA VVPIITSVVS TANETAPLEE DEEEGDIENT TVVQIGQNGQ YIAPVDLTSS GDGSCITAVV SGGEESAVHE SCSVADFALC GADHSYSLTT GTTSTELLRK LNEQRDIIAL MEIKMKEMKN TIRQLRVTEA RLQDELRQRE QERERLICAN TIIKRKL //