ID THA11_DANRE Reviewed; 257 AA. AC Q6TGZ4; Q6NYT2; DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot. DT 25-NOV-2008, sequence version 2. DT 02-NOV-2010, entry version 36. DE RecName: Full=THAP domain-containing protein 11; GN Name=thap11; ORFNames=zgc:65871; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Kidney marrow; RX PubMed=15520368; DOI=10.1073/pnas.0407241101; RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., RA Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., RA Kanki J.P., Liu T.X., Look A.T., Chen Z.; RT "Hematopoietic gene expression profile in zebrafish kidney marrow."; RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Embryo; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Transcriptional repressor that plays a central role for CC embryogenesis and the pluripotency of embryonic stem (ES) cells. CC Sequence-specific DNA-binding factor that represses gene CC expression in pluripotent ES cells by directly binding to key CC genetic loci and recruiting epigenetic modifiers (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q6TGZ4-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6TGZ4-2; Sequence=VSP_035879; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the THAP11 family. CC -!- SIMILARITY: Contains 1 THAP-type zinc finger. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY398362; AAQ97795.1; -; mRNA. DR EMBL; BC056572; AAH56572.1; -; mRNA. DR EMBL; BC066471; AAH66471.1; -; mRNA. DR IPI; IPI00492960; -. DR IPI; IPI00915154; -. DR RefSeq; NP_998267.1; -. DR UniGene; Dr.75932; -. DR ProteinModelPortal; Q6TGZ4; -. DR SMR; Q6TGZ4; 4-82. DR Ensembl; ENSDART00000052342; ENSDARP00000052341; ENSDARG00000036055. DR GeneID; 406390; -. DR KEGG; dre:406390; -. DR ZFIN; ZDB-GENE-040426-2121; zgc:65871. DR eggNOG; fiNOG13544; -. DR HOGENOM; HBG715695; -. DR HOVERGEN; HBG062269; -. DR InParanoid; Q6TGZ4; -. DR OMA; NNSHRDR; -. DR OrthoDB; EOG98976Z; -. DR PhylomeDB; Q6TGZ4; -. DR ArrayExpress; Q6TGZ4; -. DR Bgee; Q6TGZ4; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW. DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW. DR InterPro; IPR006612; Znf_C2CH. DR Pfam; PF05485; THAP; 1. DR SMART; SM00692; DM3; 1. DR SMART; SM00980; THAP; 1. DR PROSITE; PS50950; ZF_THAP; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Coiled coil; DNA-binding; Metal-binding; KW Nucleus; Repressor; Transcription; Transcription regulation; Zinc; KW Zinc-finger. FT CHAIN 1 257 THAP domain-containing protein 11. FT /FTId=PRO_0000355149. FT ZN_FING 6 64 THAP-type. FT COILED 196 251 Potential. FT VAR_SEQ 134 136 Missing (in isoform 2). FT /FTId=VSP_035879. SQ SEQUENCE 257 AA; 28728 MW; 7E464599E8687975 CRC64; MPGFTCCVPG CYNNSHRDRD LRFYTFPKDP TQREIWLKNI SRAGVSGCFS TFQPTTGHRV CSVHFPGGRK TYTIRVPTLF PLRGVNERRS RRGRSRKVSA VVPIITSVVS TANETAPLEE DEEEGDIENT TVVQIGQNGQ YIAPVDLTSS GDGSCITAVV SGGEESAVHE SCSVADFALC GADHSYSLTT GTTSTELLRK LNEQRDIIAL MEIKMKEMKN TIRQLRVTEA RLQDELRQRE QERERLICAN TIIKRKL //