ID   THA11_DANRE             Reviewed;         257 AA.
AC   Q6TGZ4; Q6NYT2;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   28-JUL-2009, entry version 24.
DE   RecName: Full=THAP domain-containing protein 11;
GN   Name=thap11; ORFNames=zgc:65871;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y.,
RA   Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I.,
RA   Kanki J.P., Liu T.X., Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that plays a central role for
CC       embryogenesis and the pluripotency of embryonic stem (ES) cells.
CC       Sequence-specific DNA-binding factor that represses gene
CC       expression in pluripotent ES cells by directly binding to key
CC       genetic loci and recruiting epigenetic modifiers (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6TGZ4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6TGZ4-2; Sequence=VSP_035879;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the THAP11 family.
CC   -!- SIMILARITY: Contains 1 THAP-type zinc finger.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY398362; AAQ97795.1; -; mRNA.
DR   EMBL; BC056572; AAH56572.1; -; mRNA.
DR   EMBL; BC066471; AAH66471.1; -; mRNA.
DR   IPI; IPI00492960; -.
DR   IPI; IPI00915154; -.
DR   RefSeq; NP_998267.1; -.
DR   UniGene; Dr.75932; -.
DR   Ensembl; ENSDART00000052342; ENSDARP00000052341; ENSDARG00000036055; Danio rerio.
DR   GeneID; 406390; -.
DR   KEGG; dre:406390; -.
DR   ZFIN; ZDB-GENE-040426-2121; zgc:65871.
DR   HOVERGEN; Q6TGZ4; -.
DR   OMA; Q6TGZ4; YNNSHRD.
DR   ArrayExpress; Q6TGZ4; -.
DR   Bgee; Q6TGZ4; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR006612; Znf_C2CH.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; DNA-binding; Metal-binding;
KW   Nucleus; Repressor; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    257       THAP domain-containing protein 11.
FT                                /FTId=PRO_0000355149.
FT   ZN_FING       6     64       THAP-type.
FT   COILED      196    251       Potential.
FT   VAR_SEQ     134    136       Missing (in isoform 2).
FT                                /FTId=VSP_035879.
SQ   SEQUENCE   257 AA;  28728 MW;  7E464599E8687975 CRC64;
     MPGFTCCVPG CYNNSHRDRD LRFYTFPKDP TQREIWLKNI SRAGVSGCFS TFQPTTGHRV
     CSVHFPGGRK TYTIRVPTLF PLRGVNERRS RRGRSRKVSA VVPIITSVVS TANETAPLEE
     DEEEGDIENT TVVQIGQNGQ YIAPVDLTSS GDGSCITAVV SGGEESAVHE SCSVADFALC
     GADHSYSLTT GTTSTELLRK LNEQRDIIAL MEIKMKEMKN TIRQLRVTEA RLQDELRQRE
     QERERLICAN TIIKRKL
//