ID Q6TGT3_DANRE Unreviewed; 115 AA. AC Q6TGT3; B2GQY4; F6PA36; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 119. DE RecName: Full=Dynein light chain Tctex-type 3 {ECO:0000256|ARBA:ARBA00039901}; GN Name=dynlt3 {ECO:0000313|EMBL:AAI64919.1, GN ECO:0000313|Ensembl:ENSDARP00000067821, GN ECO:0000313|RefSeq:NP_991171.1, ECO:0000313|ZFIN:ZDB-GENE-040927-24}; GN Synonyms=TCTE1L {ECO:0000313|EMBL:AAQ97856.1}, zgc:101678 GN {ECO:0000313|RefSeq:NP_991171.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI64919.1}; RN [1] {ECO:0000313|EMBL:AAQ97856.1, ECO:0000313|RefSeq:NP_991171.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Kidney marrow {ECO:0000313|EMBL:AAQ97856.1}; RX PubMed=15520368; DOI=10.1073/pnas.0407241101; RA Song H.D., Sun X.J., Deng M., Zhang G.W., Zhou Y., Wu X.Y., Sheng Y., RA Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Liu T.X., RA Look A.T., Chen Z.; RT "Hematopoietic gene expression profile in zebrafish kidney marrow."; RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004). RN [2] {ECO:0000313|EMBL:AAI64919.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAH81386.1}, and PCR RC rescue {ECO:0000313|EMBL:AAI64919.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSDARP00000067821} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000067821}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000313|Ensembl:ENSDARP00000067821, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000067821}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [5] {ECO:0000313|RefSeq:NP_991171.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [6] {ECO:0000313|RefSeq:NP_991171.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28252024; RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A., RA Choudhary J.S., Emes R.D., Grant S.G.; RT "Evolution of complexity in the zebrafish synapse proteome."; RL Nat. Commun. 8:14613-14613(2017). RN [7] {ECO:0000313|RefSeq:NP_991171.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of CC the cytoplasmic dynein 1 complex that are thought to be involved in CC linking dynein to cargos and to adapter proteins that regulate dynein CC function. Cytoplasmic dynein 1 acts as a motor for the intracellular CC retrograde motility of vesicles and organelles along microtubules. CC Probably binds BUB3 as part of transport cargo. Required for the CC efficient progression through mitosis. {ECO:0000256|ARBA:ARBA00037393}. CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family. CC {ECO:0000256|ARBA:ARBA00005361}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR450831; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC081386; AAH81386.1; -; mRNA. DR EMBL; BC164919; AAI64919.1; -; mRNA. DR EMBL; AY398423; AAQ97856.1; -; mRNA. DR RefSeq; NP_991171.1; NM_205608.1. DR STRING; 7955.ENSDARP00000067821; -. DR PaxDb; 7955-ENSDARP00000067821; -. DR Ensembl; ENSDART00000067822; ENSDARP00000067821; ENSDARG00000046132. DR Ensembl; ENSDART00000067822.5; ENSDARP00000067821.4; ENSDARG00000046132.5. DR GeneID; 402901; -. DR KEGG; dre:402901; -. DR AGR; ZFIN:ZDB-GENE-040927-24; -. DR CTD; 6990; -. DR ZFIN; ZDB-GENE-040927-24; dynlt3. DR eggNOG; KOG4081; Eukaryota. DR HOGENOM; CLU_097204_7_2_1; -. DR OMA; EEYHRPC; -. DR OrthoDB; 3679412at2759; -. DR TreeFam; TF313904; -. DR Proteomes; UP000000437; Chromosome 11. DR Bgee; ENSDARG00000046132; Expressed in swim bladder and 27 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central. DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central. DR CDD; cd21463; DLC-like_DYNLT3; 1. DR Gene3D; 3.30.1140.40; Tctex-1; 1. DR InterPro; IPR005334; Tctex-1-like. DR InterPro; IPR038586; Tctex-1-like_sf. DR PANTHER; PTHR21255:SF20; DYNEIN LIGHT CHAIN TCTEX-TYPE 3; 1. DR PANTHER; PTHR21255; T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN; 1. DR Pfam; PF03645; Tctex-1; 1. PE 1: Evidence at protein level; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306}; KW Cell division {ECO:0000256|ARBA:ARBA00022618}; KW Centromere {ECO:0000256|ARBA:ARBA00023328}; KW Chromosome {ECO:0000256|ARBA:ARBA00022454}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212}; KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}; KW Dynein {ECO:0000256|ARBA:ARBA00023017}; KW Kinetochore {ECO:0000256|ARBA:ARBA00022838}; KW Microtubule {ECO:0000256|ARBA:ARBA00022701}; KW Mitosis {ECO:0000256|ARBA:ARBA00022776}; KW Motor protein {ECO:0000256|ARBA:ARBA00023175}; KW Nitration {ECO:0000256|ARBA:ARBA00023074}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6TGT3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Transport {ECO:0000256|ARBA:ARBA00022448}. SQ SEQUENCE 115 AA; 12688 MW; A3A2983CE7C0CAC0 CRC64; MEEYHSGDEV SFNPDDASNV VKECIEGIIG GVDYSQNKVN QWTASIVEHS LTQLVKQGKP FKYIVNCAVM QKSGAGLHTA NSCYWDTTTD GSCTVRWENR TMYCVVSVFA VAIAL //