ID Q6SV71_HUMAN Unreviewed; 73 AA. AC Q6SV71; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 27-NOV-2024, entry version 74. DE SubName: Full=LIM homeobox 8 {ECO:0000313|EMBL:AAR18074.1}; DE Flags: Fragment; GN Name=LHX8 {ECO:0000313|EMBL:AAR18074.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAR18074.1}; RN [1] {ECO:0000313|EMBL:AAR18074.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16327884; DOI=10.1371/journal.pgen.0010064; RA Vieira A.R., Avila J.R., Daack-Hirsch S., Dragan E., Felix T.M., RA Rahimov F., Harrington J., Schultz R.R., Watanabe Y., Johnson M., Fang J., RA O'brien S.E., Orioli I.M., Castilla E.E., Fitzpatrick D.R., Jiang R., RA Marazita M.L., Murray J.C.; RT "Medical sequencing of candidate genes for nonsyndromic cleft lip and RT palate."; RL PLoS Genet. 1:E64-E64(2005). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AH013373; AAR18074.1; -; Genomic_DNA. DR AlphaFoldDB; Q6SV71; -. DR PeptideAtlas; Q6SV71; -. DR ChiTaRS; LHX8; human. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR FunFam; 2.10.110.10:FF:000023; LIM homeobox 6; 1. DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1. DR InterPro; IPR050453; LIM_Homeobox_TF. DR InterPro; IPR001781; Znf_LIM. DR PANTHER; PTHR24208; LIM/HOMEOBOX PROTEIN LHX; 1. DR PANTHER; PTHR24208:SF117; LIM_HOMEOBOX PROTEIN LHX8; 1. DR Pfam; PF00412; LIM; 1. DR SMART; SM00132; LIM; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR PROSITE; PS00478; LIM_DOMAIN_1; 1. DR PROSITE; PS50023; LIM_DOMAIN_2; 1. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:AAR18074.1}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000313|EMBL:AAR18074.1}; KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE- KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}. FT DOMAIN 4..66 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAR18074.1" FT NON_TER 73 FT /evidence="ECO:0000313|EMBL:AAR18074.1" SQ SEQUENCE 73 AA; 8619 MW; 91CD724DBBDA377A CRC64; RYGTRCSRCG RHIHSTDWVR RAKGNVYHLA CFACFSCKRQ LSTGEEFALV EEKVLCRVHY DCMLHNLKRE VEN //