ID Q6R5J6_RAT Unreviewed; 275 AA. AC Q6R5J6; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 15-MAR-2017, entry version 81. DE SubName: Full=NYGGF5 {ECO:0000313|EMBL:AAR97577.1}; DE SubName: Full=Solute carrier family 25, member 27 {ECO:0000313|Ensembl:ENSRNOP00000039207}; GN Name=Slc25a27 {ECO:0000313|Ensembl:ENSRNOP00000039207, GN ECO:0000313|RGD:620787}; GN Synonyms=Nyggf5 {ECO:0000313|EMBL:AAR97577.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAR97577.1}; RN [1] {ECO:0000313|EMBL:AAR97577.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAR97577.1}; RA Gui X., Ni Y., Zhang M., Wang B., Gong H., Fei L., Qian L., Zhao Y., RA Chi X., Chen R., Guo M., Pan X., Zhou M., Hong H., Tan Z.; RT "A new gene cloned from the cDNA library of rat adipose tissue."; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSRNOP00000039207, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039207, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., RA Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., RA Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., RA Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., RA Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., RA Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., RA Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., RA Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., RA Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., RA D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., RA Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., RA Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., RA Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., RA Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., RA Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., RA Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., RA Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., RA Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., RA Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., RA Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., RA Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., RA Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., RA Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., RA Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., RA Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., RA Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., RA Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., RA Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., RA Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., RA Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., RA Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., RA Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., RA Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., RA Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., RA Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into RT mammalian evolution."; RL Nature 428:493-521(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000039207} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039207}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) CC family. {ECO:0000256|RuleBase:RU000488, CC ECO:0000256|SAAS:SAAS00548220}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AABR07066866; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY512661; AAR97577.1; -; mRNA. DR UniGene; Rn.163043; -. DR STRING; 10116.ENSRNOP00000039207; -. DR Ensembl; ENSRNOT00000052068; ENSRNOP00000039207; ENSRNOG00000010592. DR RGD; 620787; Slc25a27. DR eggNOG; KOG0753; Eukaryota. DR eggNOG; ENOG410XRV1; LUCA. DR GeneTree; ENSGT00760000119170; -. DR HOVERGEN; HBG009528; -. DR OMA; RMTPWSL; -. DR OrthoDB; EOG091G0BQ7; -. DR TreeFam; TF354328; -. DR Reactome; R-RNO-167826; The fatty acid cycling model. DR Reactome; R-RNO-167827; The proton buffering model. DR Proteomes; UP000002494; Chromosome 9. DR Bgee; ENSRNOG00000010592; -. DR GO; GO:0045177; C:apical part of cell; IDA:RGD. DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central. DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central. DR GO; GO:0043025; C:neuronal cell body; IDA:RGD. DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0035356; P:cellular triglyceride homeostasis; IDA:RGD. DR GO; GO:0048839; P:inner ear development; IEP:RGD. DR GO; GO:0006839; P:mitochondrial transport; IBA:GO_Central. DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD. DR GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; IMP:RGD. DR GO; GO:0010917; P:negative regulation of mitochondrial membrane potential; IDA:RGD. DR GO; GO:0070997; P:neuron death; IMP:RGD. DR GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD. DR GO; GO:0046324; P:regulation of glucose import; IDA:RGD. DR GO; GO:0009409; P:response to cold; IBA:GO_Central. DR Gene3D; 1.50.40.10; -; 1. DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier. DR InterPro; IPR023395; Mt_carrier_dom. DR Pfam; PF00153; Mito_carr; 3. DR SUPFAM; SSF103506; SSF103506; 1. DR PROSITE; PS50920; SOLCAR; 3. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000002494}; KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00282, KW ECO:0000256|SAAS:SAAS00423863}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00282, KW ECO:0000256|RuleBase:RU000488, ECO:0000256|SAAS:SAAS00013444}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00013441}; KW Transport {ECO:0000256|RuleBase:RU000488}. FT REPEAT 1 67 Solcar. {ECO:0000256|PROSITE-ProRule: FT PRU00282}. FT REPEAT 77 169 Solcar. {ECO:0000256|PROSITE-ProRule: FT PRU00282}. FT REPEAT 178 269 Solcar. {ECO:0000256|PROSITE-ProRule: FT PRU00282}. SQ SEQUENCE 275 AA; 30536 MW; 118AE780E40219F1 CRC64; MQGEAALAKL GDGAMESAPY RGMMRTALGI VQEEGFLKLW QGVTPAIYRH VVYSGGRMVT YEHLREVVFG KSEDEHYPLW KSVIGGMMAG VIGQFLANPT DLVKVQMQME GKRRLEGKPL RFRGVHHAFA KILAEGGIRG LWAGWIPNIQ RAALVNMGDL TTYDTVKHYL VLNTALEDNI ATHGLSSLCS GLVASILGTP ADVIKSRIMN QPRDKQGRGL LYKSSTDCVI QAVQGEGFLS LYKGFLPSWL RMTPWSMVFW LTYEKIRQLS GVSPF //