ID Q6R5J6_RAT Unreviewed; 275 AA. AC Q6R5J6; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JAN-2024, entry version 116. DE SubName: Full=NYGGF5 {ECO:0000313|EMBL:AAR97577.1}; GN Name=Slc25a27 {ECO:0000313|RGD:620787}; GN Synonyms=Nyggf5 {ECO:0000313|EMBL:AAR97577.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAR97577.1}; RN [1] {ECO:0000313|EMBL:AAR97577.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAR97577.1}; RA Gui X., Ni Y., Zhang M., Wang B., Gong H., Fei L., Qian L., Zhao Y., RA Chi X., Chen R., Guo M., Pan X., Zhou M., Hong H., Tan Z.; RT "A new gene cloned from the cDNA library of rat adipose tissue."; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family. CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY512661; AAR97577.1; -; mRNA. DR AlphaFoldDB; Q6R5J6; -. DR SMR; Q6R5J6; -. DR STRING; 10116.ENSRNOP00000039207; -. DR PaxDb; 10116-ENSRNOP00000039207; -. DR AGR; RGD:620787; -. DR RGD; 620787; Slc25a27. DR VEuPathDB; HostDB:ENSRNOG00000010592; -. DR eggNOG; KOG0753; Eukaryota. DR HOGENOM; CLU_015166_14_2_1; -. DR InParanoid; Q6R5J6; -. DR Reactome; R-RNO-167826; The fatty acid cycling model. DR Reactome; R-RNO-167827; The proton buffering model. DR Bgee; ENSRNOG00000010592; Expressed in cerebellum and 12 other cell types or tissues. DR GO; GO:0045177; C:apical part of cell; IDA:RGD. DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD. DR GO; GO:0031966; C:mitochondrial membrane; ISO:RGD. DR GO; GO:0005739; C:mitochondrion; ISO:RGD. DR GO; GO:0043025; C:neuronal cell body; IDA:RGD. DR GO; GO:0015108; F:chloride transmembrane transporter activity; ISO:RGD. DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD. DR GO; GO:0015078; F:proton transmembrane transporter activity; ISO:RGD. DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0048839; P:inner ear development; IEP:RGD. DR GO; GO:0035356; P:intracellular triglyceride homeostasis; IDA:RGD. DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD. DR GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; IMP:RGD. DR GO; GO:0010917; P:negative regulation of mitochondrial membrane potential; IDA:RGD. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD. DR GO; GO:0046324; P:regulation of glucose import; IDA:RGD. DR GO; GO:0009409; P:response to cold; IBA:GO_Central. DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1. DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier. DR InterPro; IPR023395; Mt_carrier_dom_sf. DR PANTHER; PTHR45618; MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED; 1. DR PANTHER; PTHR45618:SF8; MITOCHONDRIAL UNCOUPLING PROTEIN 4; 1. DR Pfam; PF00153; Mito_carr; 3. DR SUPFAM; SSF103506; Mitochondrial carrier; 1. DR PROSITE; PS50920; SOLCAR; 3. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE- KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE- KW ProRule:PRU00282}; Transport {ECO:0000256|RuleBase:RU000488}. FT REPEAT 1..67 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" FT REPEAT 77..169 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" FT REPEAT 178..269 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" SQ SEQUENCE 275 AA; 30536 MW; 118AE780E40219F1 CRC64; MQGEAALAKL GDGAMESAPY RGMMRTALGI VQEEGFLKLW QGVTPAIYRH VVYSGGRMVT YEHLREVVFG KSEDEHYPLW KSVIGGMMAG VIGQFLANPT DLVKVQMQME GKRRLEGKPL RFRGVHHAFA KILAEGGIRG LWAGWIPNIQ RAALVNMGDL TTYDTVKHYL VLNTALEDNI ATHGLSSLCS GLVASILGTP ADVIKSRIMN QPRDKQGRGL LYKSSTDCVI QAVQGEGFLS LYKGFLPSWL RMTPWSMVFW LTYEKIRQLS GVSPF //