ID Q6PVC0_DROSI Unreviewed; 604 AA. AC Q6PVC0; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 29-MAY-2024, entry version 66. DE RecName: Full=Period circadian protein {ECO:0000256|ARBA:ARBA00040849}; DE Flags: Fragment; GN Name=per {ECO:0000313|FlyBase:FBgn0012888}; OS Drosophila simulans (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7240 {ECO:0000313|EMBL:AAS88950.1}; RN [1] {ECO:0000313|EMBL:AAS88950.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RU35 {ECO:0000313|EMBL:AAS88950.1}; RX PubMed=15288072; DOI=10.1016/j.ympev.2004.03.013; RA Dean M.D., Ballard J.W.O.; RT "Linking phylogenetics with population genetics to reconstruct the RT geographic origin of a species."; RL Mol. Phylogenet. Evol. 32:998-1009(2004). CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region CC {ECO:0000256|ARBA:ARBA00004556}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY575830; AAS88950.1; -; Genomic_DNA. DR AlphaFoldDB; Q6PVC0; -. DR FlyBase; FBgn0012888; Dsim\per. DR GO; GO:0044297; C:cell body; IEA:EnsemblMetazoa. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:TreeGrafter. DR GO; GO:0001222; F:transcription corepressor binding; IEA:TreeGrafter. DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:EnsemblMetazoa. DR GO; GO:0060086; P:circadian temperature homeostasis; IEA:EnsemblMetazoa. DR GO; GO:0007620; P:copulation; IEA:EnsemblMetazoa. DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa. DR GO; GO:0008062; P:eclosion rhythm; IEA:EnsemblMetazoa. DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IEA:EnsemblMetazoa. DR GO; GO:0045475; P:locomotor rhythm; IEA:EnsemblMetazoa. DR GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa. DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa. DR GO; GO:1904059; P:regulation of locomotor rhythm; IEA:EnsemblMetazoa. DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:EnsemblMetazoa. DR GO; GO:0006979; P:response to oxidative stress; IEA:EnsemblMetazoa. DR CDD; cd00130; PAS; 2. DR Gene3D; 3.30.450.20; PAS domain; 2. DR Gene3D; 1.20.5.770; Single helix bin; 1. DR InterPro; IPR000014; PAS. DR InterPro; IPR035965; PAS-like_dom_sf. DR InterPro; IPR013767; PAS_fold. DR PANTHER; PTHR11269; PERIOD CIRCADIAN PROTEIN; 1. DR PANTHER; PTHR11269:SF16; PERIOD CIRCADIAN PROTEIN; 1. DR Pfam; PF00989; PAS; 1. DR Pfam; PF14598; PAS_11; 1. DR SMART; SM00091; PAS; 2. DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2. DR PROSITE; PS50112; PAS; 2. PE 4: Predicted; KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 243..292 FT /note="PAS" FT /evidence="ECO:0000259|PROSITE:PS50112" FT DOMAIN 394..442 FT /note="PAS" FT /evidence="ECO:0000259|PROSITE:PS50112" FT REGION 1..170 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..59 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 79..93 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 118..134 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAS88950.1" FT NON_TER 604 FT /evidence="ECO:0000313|EMBL:AAS88950.1" SQ SEQUENCE 604 AA; 65863 MW; 60A65D6705CE58FA CRC64; ESTESTHNTK VSDSAYSNSC SNSQSQRSGS SKSRLSGSHS SGSSGYGGKP STQASSSDMI IKRNKDKSRK KKKNKGAGQG AGQAQTLISA STSLEGRDEE KPRPSGTGCV EQQICRELQD QQHGEDHSEP QATEQLQQEE EDQSGSESEA DRVEGVAKSE AAQSFPIPSP LSVTIVPPSM GGCGGVGHAA GLDSGLAKFD KTWEAGPGKL ESMTGVGAAA AGTGQRGERV KEDSFCCVIS MHDGIVLYTT PSITDVLGYP RDMWLGRSFI DFVHLKDRAT FASQITTGIP IAESRGSVPK DAKSTFCVML RRYRGLKSGG FGVIGRPVSY EPFRLGLTFR EAPEEARPDN YMVSNGTNML LVICATPIKS SYKVPDEILS QKSPKFAIRH TATGIISHVD SAAVSALGYL PQDLIGRSIM DFYHHEDLSV MKETYETVMK KGQTAGASFC SKAYRFLIQN GCYVLLETEW TSFVNPWSRK LEFVVGHHRV FQGPKQCNVF EAAPTCKLKI SEEAQSRNTR IKEDIVKRLA ETVSRPSDTV KQEVSRRCQA LASFMETLMD EVSRADLKLE LPHENELTVS ERDSVMLGEI SPHHDYYDSK SSTE //