ID ECTC_VIRPA Reviewed; 128 AA. AC Q6PR31; DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 24-JUL-2007, entry version 16. DE L-ectoine synthase (EC 4.2.1.-) (N-acetyldiaminobutyrate dehydratase). GN Name=ectC; OS Virgibacillus pantothenticus. OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Virgibacillus. OX NCBI_TaxID=1473; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Kuhlmann A.U., Gimpel S., Hoffmann T., Bremer E.; RT "Synthesis of compatible solute ectoine in Virgibacillus RT pantothenticus is induced by high osmolality and growth in the cold."; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the circularization of gamma-N-acetyl- CC alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- CC tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an CC excellent osmoprotectant (By similarity). CC -!- CATALYTIC ACTIVITY: N-acetyl-L-2,4-diaminobutanoate = L-ectoine + CC H(2)O. CC -!- PATHWAY: Amine and polyamine biosynthesis; ectoine biosynthesis; CC L-ectoine from L-aspartate 4-semialdehyde: step 3/3. CC -!- SIMILARITY: Belongs to the ectoine synthase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY585263; AAS93808.1; -; Genomic_DNA. DR GO; GO:0016836; F:hydro-lyase activity; IEA:HAMAP. DR GO; GO:0019491; P:ectoine biosynthetic process; IEA:HAMAP. DR HAMAP; MF_01255; -; 1. DR InterPro; IPR010462; Ectoine_synth. DR Pfam; PF06339; Ectoine_synth; 1. PE 3: Inferred from homology; KW Lyase. FT CHAIN 1 128 L-ectoine synthase. FT /FTId=PRO_0000220161. SQ SEQUENCE 128 AA; 14775 MW; E893506E5AE969B2 CRC64; MIVKSLDDII GTDDETSSDN WTSRRFIMKK DNVGFSLNDT LIKAGTTNFF WYKNHIEAVY CIEGEGEIEK LETGEIYKLK AGTMYLLNEH DKHELRAKTQ MRMVCVFNPP LVGTETHTEE GYYPLLTE //