ID MYO7B_HUMAN Reviewed; 2116 AA. AC Q6PIF6; Q14786; Q8TEE1; DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 08-APR-2008, sequence version 2. DT 01-MAY-2013, entry version 82. DE RecName: Full=Unconventional myosin-VIIb; GN Name=MYO7B; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 166-196 (ISOFORMS 1/2). RX PubMed=8022818; DOI=10.1073/pnas.91.14.6549; RA Bement W.M., Hasson T., Wirth J.A., Cheney R.E., Mooseker M.S.; RT "Identification and overlapping expression of multiple unconventional RT myosin genes in vertebrate cell types."; RL Proc. Natl. Acad. Sci. U.S.A. 91:6549-6553(1994). RN [3] RP ERRATUM. RX PubMed=7972138; DOI=10.1073/pnas.91.24.11767c; RA Bement W.M., Hasson T., Wirth J.A., Cheney R.E., Mooseker M.S.; RL Proc. Natl. Acad. Sci. U.S.A. 91:11767-11767(1994). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1102-2116 (ISOFORM 2). RC TISSUE=Spleen; RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.; RT "The nucleotide sequence of a long cDNA clone isolated from human RT spleen."; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1451-2116 (ISOFORM 1). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Myosins are actin-based motor molecules with ATPase CC activity. Their highly divergent tails are presumed to bind to CC membranous compartments, which would be moved relative to actin CC filaments. May be have a role in the apical membranes of CC transporting epithelia (By similarity). CC -!- SUBCELLULAR LOCATION: Apical cell membrane (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q6PIF6-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6PIF6-2; Sequence=VSP_032930, VSP_032931; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Contains 2 FERM domains. CC -!- SIMILARITY: Contains 6 IQ domains. CC -!- SIMILARITY: Contains 1 myosin head-like domain. CC -!- SIMILARITY: Contains 3 MyTH4 domains. CC -!- SIMILARITY: Contains 2 SH3 domains. CC -!- CAUTION: Represents a unconventional myosin. This protein should CC not be confused with the conventional myosin-7 (MYH7). CC -!- SEQUENCE CAUTION: CC Sequence=AAH35615.2; Type=Erroneous initiation; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC010976; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; L29147; AAA20910.1; -; mRNA. DR EMBL; AK074183; BAB85009.1; -; mRNA. DR EMBL; BC035615; AAH35615.2; ALT_INIT; mRNA. DR IPI; IPI00889512; -. DR IPI; IPI00939150; -. DR RefSeq; NP_001073996.1; NM_001080527.1. DR UniGene; Hs.154578; -. DR UniGene; Hs.677195; -. DR ProteinModelPortal; Q6PIF6; -. DR STRING; 9606.ENSP00000415090; -. DR DMDM; 182667924; -. DR PaxDb; Q6PIF6; -. DR PRIDE; Q6PIF6; -. DR Ensembl; ENST00000409816; ENSP00000386461; ENSG00000169994. DR Ensembl; ENST00000428314; ENSP00000415090; ENSG00000169994. DR GeneID; 4648; -. DR KEGG; hsa:4648; -. DR UCSC; uc002top.3; human. DR CTD; 4648; -. DR GeneCards; GC02P128282; -. DR H-InvDB; HIX0002437; -. DR HGNC; HGNC:7607; MYO7B. DR HPA; HPA039131; -. DR MIM; 606541; gene. DR neXtProt; NX_Q6PIF6; -. DR PharmGKB; PA31412; -. DR eggNOG; COG5022; -. DR HOGENOM; HOG000007836; -. DR HOVERGEN; HBG052557; -. DR KO; K10359; -. DR ChiTaRS; MYO7B; human. DR GenomeRNAi; 4648; -. DR NextBio; 17916; -. DR ArrayExpress; Q6PIF6; -. DR Bgee; Q6PIF6; -. DR CleanEx; HS_MYO7B; -. DR Genevestigator; Q6PIF6; -. DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003774; F:motor activity; IEA:InterPro. DR Gene3D; 1.20.80.10; -; 2. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR000048; IQ_motif_EF-hand-BS. DR InterPro; IPR001609; Myosin_head_motor_dom. DR InterPro; IPR000857; MyTH4_dom. DR InterPro; IPR011993; PH_like_dom. DR InterPro; IPR011511; SH3_2. DR InterPro; IPR001452; SH3_domain. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF00612; IQ; 4. DR Pfam; PF00063; Myosin_head; 1. DR Pfam; PF00784; MyTH4; 2. DR Pfam; PF07653; SH3_2; 1. DR PRINTS; PR00193; MYOSINHEAVY. DR SMART; SM00295; B41; 2. DR SMART; SM00015; IQ; 4. DR SMART; SM00242; MYSc; 1. DR SMART; SM00139; MyTH4; 2. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF47031; FERM_3-hlx; 2. DR SUPFAM; SSF50044; SH3; 1. DR PROSITE; PS00660; FERM_1; FALSE_NEG. DR PROSITE; PS00661; FERM_2; FALSE_NEG. DR PROSITE; PS50057; FERM_3; 2. DR PROSITE; PS50096; IQ; 4. DR PROSITE; PS51016; MYTH4; 2. DR PROSITE; PS50002; SH3; 1. PE 2: Evidence at transcript level; KW Actin-binding; Alternative splicing; ATP-binding; Cell membrane; KW Complete proteome; Membrane; Motor protein; Myosin; KW Nucleotide-binding; Polymorphism; Reference proteome; Repeat; KW SH3 domain. FT CHAIN 1 2116 Unconventional myosin-VIIb. FT /FTId=PRO_0000329046. FT DOMAIN 67 729 Myosin head-like. FT DOMAIN 745 765 IQ 1. FT DOMAIN 763 792 IQ 2. FT DOMAIN 786 815 IQ 3. FT DOMAIN 814 834 IQ 4. FT DOMAIN 832 861 IQ 5. FT DOMAIN 855 884 IQ 6. FT DOMAIN 989 1192 MyTH4 1. FT DOMAIN 1197 1506 FERM 1. FT DOMAIN 1501 1567 SH3 1. FT DOMAIN 1606 1670 SH3 2. FT DOMAIN 1644 1793 MyTH4 2. FT DOMAIN 1790 1896 MyTH4 3. FT DOMAIN 1799 2102 FERM 2. FT VAR_SEQ 1851 1957 ISQKEGDFFFDSLREVSDWVKKNKPQKEGAPVTLPYQVYFM FT RKLWLNISPGKDVNADTILHYHQELPKYLRGFHKCSREDAI FT HLAGLIYKAQFNNDRSQLASVPKIL -> GRAGAGQTVGGR FT AVSEALGAACGGLSLPGAPMLDQAAGTEVGGVLEQSQLHTP FT IAHAQPTPAQHPGRRRPLDQNPAGSQEDSPRKPPNFPVPSP FT SPGHQPEGGRLLL (in isoform 2). FT /FTId=VSP_032930. FT VAR_SEQ 1958 2116 Missing (in isoform 2). FT /FTId=VSP_032931. FT VARIANT 21 21 G -> S (in dbSNP:rs2404991). FT /FTId=VAR_042626. FT VARIANT 1264 1264 R -> Q (in dbSNP:rs2245408). FT /FTId=VAR_042627. FT VARIANT 1647 1647 E -> D (in dbSNP:rs13025959). FT /FTId=VAR_042628. FT VARIANT 2105 2105 Q -> R (in dbSNP:rs11686946). FT /FTId=VAR_042629. FT CONFLICT 182 182 H -> D (in Ref. 2; AAA20910). FT CONFLICT 1102 1106 LRPSL -> WSVSF (in Ref. 4; BAB85009). SQ SEQUENCE 2116 AA; 241599 MW; 18E908998470E4FD CRC64; MSGFRLGDHV WLEPPSTHKT GVAIGGIIKE AKPGKVLVED DEGKEHWIRA EDFGVLSPMH PNSVQGVDDM IRLGDLNEAG MVHNLLIRYQ QHKIYTYTGS ILVAVNPFQV LPLYTLEQVQ LYYSRHMGEL PPHVFAIANN CYFSMKRNKR DQCCIISGES GAGKTETTKL ILQFLATISG QHSWIEQQVL EANPILEAFG NAKTIRNDNS SRFGKYIDIY FNPSGVIEGA RIEQFLLEKS RVCRQAPEER NYHIFYCMLM GVSAEDKQLL SLGTPSEYHY LTMGNCTSCE GLNDAKDYAH IRSAMKILQF SDSESWDVIK LLAAILHLGN VGFMASVFEN LDASDVMETP AFPTVMKLLE VQHQELRDCL IKHTILIRGE FVTRSLNIAQ AADRRDAFVK GIYGHLFLWI VKKINAAIFT PPAQDPKNVR RAIGLLDIFG FENFENNSFE QLCINFANEH LQQFFVQHVF TMEQEEYRSE NISWDYIHYT DNRPTLDLLA LKPMSIISLL DEESRFPQGT DLTMLQKLNS VHANNKAFLQ PKNIHDARFG IAHFAGEVYY QAEGFLEKNR DVLSTDILTL VYSSKNKFLR EIFNLELAET KLGHGTIRQA KAGNHLFKSA DSNKRPSTLG SQFKQSLDQL MKILTNCQPY FIRCIKPNEY KKPLLFDREL CLRQLRYSGM METVHIRKSG FPIRYTFEEF SQRFGVLLPN AMRMQLQGKL RQMTLGITDV WLRTDKDWKA GKTKIFLRDH QDTLLEVQRS QVLDRAALSI QKVLRGYRYR KEFLRQRRAA VTLQAWWRGY CNRRNFKLIL VGFERLQAIA RSQPLARQYQ AMRQRTVQLQ ALCRGYLVRQ QVQAKRRAVV VIQAHARGMA ARRNFQQRKA NAPLVIPAEG QKSQGALPAK KRRSIYDTVT DTEMVEKVFG FLPAMIGGQE GQASPHFEDL ESKTQKLLEV DLDTVPMAEE PEEDVDGLAE YTFPKFAVTY FQKSASHTHI RRPLRYPLLY HEDDTDCLAA LVIWNVILRF MGDLPEPVLY ARSSQQGSSV MRQIHDTLGR EHGAQVPQHS RSAQVASQLN IGEEALEPDG LGADRPMSNL EKVHFIVGYA ILRPSLRDEI YCQICKQLSE NFKTSSLARG WILLSLCLGC FPPSERFMKY LLNFIGQGPA TYGPFCAERL RRTYANGVRA EPPTWLELQA VKSKKHIPIQ VILATGESLT VPVDSASTSR EMCMHIAHKQ GLSDHLGFSL QVAVYDKFWS LGSGRDHMMD AIARCEQMAQ ERGESQRQSP WRIYFRKEFF TPWHDSREDP VSTELIYRQV LRGVWSGEYS FEKEEELVEL LARHCYVQLG ASAESKAVQE LLPSCIPHKL YRTKPPDRWA SLVTAACAKA PYTQKQVTPL AVREQVVDAA RLQWPLLFSR LFEVITLSGP RLPKTQLILA VNWKGLCFLD QQEKMLLELS FPEVMGLATN REAQGGQRLL LSTMHEEYEF VSPSSVAIAE LVALFLEGLK ERSIFAMALQ DRKATDDTTL LAFKKGDLLV LTKKQGLLAS ENWTLGQNDR TGKTGLVPMA CLYTIPTVTK PSAQLLSLLA MSPEKRKLAA QEGQFTEPRP EEPPKEKLHT LEEFSYEFFR APEKDMVSMA VLPLARARGH LWAYSCEPLR QPLLKRVHAN VDLWDIACQI FVAILRYMGD YPSRQAWPTL ELTDQIFTLA LQHPALQDEV YCQILKQLTH NSNRHSEERG WQLLWLCTGL FPPSKGLLPH AQKFIDTRRG KLLAPDCSRR IQKVLRTGPR KQPPHQVEVE AAEQNVSRIC HKIYFPNDTS EMLEVVANTR VRDVCDSIAT RLQLASWEGC SLFIKISDKV ISQKEGDFFF DSLREVSDWV KKNKPQKEGA PVTLPYQVYF MRKLWLNISP GKDVNADTIL HYHQELPKYL RGFHKCSRED AIHLAGLIYK AQFNNDRSQL ASVPKILREL VPENLTRLMS SEEWKKSILL AYDKHKDKTV EEAKVAFLKW ICRWPTFGSA FFEVKQTSEP SYPDVILIAI NRHGVLLIHP KTKDLLTTYP FTKISSWSSG STYFHMALGS LGRGSRLLCE TSLGYKMDDL LTSYVQQLLS AMNKQRGSKA PALAST //