ID Q6PEB5_MOUSE PRELIMINARY; PRT; 338 AA. AC Q6PEB5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 02-MAY-2006, entry version 21. DE H2-Bl protein (Truncated MHC class I antigen splice variant Bl.1a). GN Name=H2-Bl; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mix FVB/N; TISSUE=Mammary tumor. WAP-TGF alpha model. 7 months RC old; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mix FVB/N; TISSUE=Mammary tumor. WAP-TGF alpha model. 7 months RC old; RG NIH MGC Project; RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=CD1, and FVB/NJ; TISSUE=Small intestine; RX PubMed=16210630; RA Guidry P.A., Stroynowski I.; RT "The Murine Family of Gut-Restricted Class Ib MHC Includes RT Alternatively Spliced Isoforms of the Proposed HLA-G Homolog, RT 'Blastocyst MHC'."; RL J. Immunol. 175:5248-5259(2005). CC -!- FUNCTION: Beta-2-microglobulin is the beta-chain of major CC histocompatibility complex class I molecules (By similarity). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system (By similarity). CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin) (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted protein (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC058170; AAH58170.1; -; mRNA. DR EMBL; AY989854; AAY51869.1; -; mRNA. DR EMBL; AY989853; AAY51868.1; -; mRNA. DR HSSP; Q9TQH5; 1B0R. DR SMR; Q6PEB5; 21-286. DR MGI; MGI:892004; H2-Bl. DR GO; GO:0009986; C:cell surface; IDA. DR GO; GO:0005737; C:cytoplasm; IDA. DR GO; GO:0016021; C:integral to membrane; IDA. DR GO; GO:0005886; C:plasma membrane; IDA. DR GO; GO:0006955; P:immune response; RCA. DR GO; GO:0042270; P:protection from natural killer cell mediate...; IDA. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR003006; Ig_MHC. DR InterPro; IPR001039; MHC_I_alpha_A1A2. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR ProDom; PD000050; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; UNKNOWN_1. KW Immune response; Immunoglobulin domain; MHC I. SQ SEQUENCE 338 AA; 38077 MW; AA892E687FCF61C0 CRC64; MAQRTLLLLL AAALTMIQTR AVFGPGLGEP RFISVGYVDN TQFVSFDSDA ENPRSEPRSP WMEQEGPEYW ERETQIAKDN EQSFGWSLRN LIHYYNQSKG GFHTFQRLSG CDMGLDGRLL RGYLQFAYDG RDYIALNEDL KTWMAADLVA LITRRKWEQA GAAELYKFYL EGECVEWLRR YLELGNETLL RTDPPKAHVT RHPRPAGDVT LRCWALGFYP ADITLTWQLN GEELTQDMEL VETRPAGDGT FQKWAAVVVP LGKEQNYTCR VHHEGLPEPL TLRWEPPPST GSNMVNIAVL VVLGAVIIIE AMVAFALKSR RKIAILPGPA GTRGSSAS //