ID Q6PEB5_MOUSE Unreviewed; 338 AA. AC Q6PEB5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 03-MAY-2023, entry version 142. DE SubName: Full=H2-Bl protein {ECO:0000313|EMBL:AAH58170.1}; DE SubName: Full=Truncated MHC class I antigen splice variant Bl.1a {ECO:0000313|EMBL:AAY51868.1}; GN Name=H2-Bl {ECO:0000313|EMBL:AAH58170.1, ECO:0000313|MGI:MGI:892004}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH58170.1}; RN [1] {ECO:0000313|EMBL:AAH58170.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Mix FVB/N {ECO:0000313|EMBL:AAH58170.1}; RC TISSUE=Mammary tumor. WAP-TGF alpha model. 7 months old RC {ECO:0000313|EMBL:AAH58170.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|EMBL:AAY51868.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CD1 {ECO:0000313|EMBL:AAY51868.1}, and FVB/NJ RC {ECO:0000313|EMBL:AAY51869.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:AAY51868.1}; RX PubMed=16210630; RA Guidry P.A., Stroynowski I.; RT "The murine family of gut-restricted class Ib MHC includes alternatively RT spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC"."; RL J. Immunol. 175:5248-5259(2005). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC058170; AAH58170.1; -; mRNA. DR EMBL; AY989853; AAY51868.1; -; mRNA. DR EMBL; AY989854; AAY51869.1; -; mRNA. DR AlphaFoldDB; Q6PEB5; -. DR MGI; MGI:892004; H2-Bl. DR ChiTaRS; H2-Bl; mouse. DR GO; GO:0009986; C:cell surface; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IDA:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IBA:GO_Central. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IBA:GO_Central. DR GO; GO:0006955; P:immune response; IBA:GO_Central. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IBA:GO_Central. DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:MGI. DR CDD; cd21016; IgC1_MHC_Ib_T10_T22_like; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF251; CLASS IB MHC ANTIGEN QA-2-RELATED; 1. DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..338 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014310596" FT TRANSMEM 297..317 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 195..283 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT REGION 47..66 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 338 AA; 38077 MW; AA892E687FCF61C0 CRC64; MAQRTLLLLL AAALTMIQTR AVFGPGLGEP RFISVGYVDN TQFVSFDSDA ENPRSEPRSP WMEQEGPEYW ERETQIAKDN EQSFGWSLRN LIHYYNQSKG GFHTFQRLSG CDMGLDGRLL RGYLQFAYDG RDYIALNEDL KTWMAADLVA LITRRKWEQA GAAELYKFYL EGECVEWLRR YLELGNETLL RTDPPKAHVT RHPRPAGDVT LRCWALGFYP ADITLTWQLN GEELTQDMEL VETRPAGDGT FQKWAAVVVP LGKEQNYTCR VHHEGLPEPL TLRWEPPPST GSNMVNIAVL VVLGAVIIIE AMVAFALKSR RKIAILPGPA GTRGSSAS //