ID Q6PCM9_MOUSE Unreviewed; 529 AA. AC Q6PCM9; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 06-JUL-2016, entry version 77. DE SubName: Full=Notch2 protein {ECO:0000313|EMBL:AAH59256.1}; GN Name=Notch2 {ECO:0000313|EMBL:AAH59256.1, ECO:0000313|MGI:MGI:97364}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH59256.1}; RN [1] {ECO:0000313|EMBL:AAH59256.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH59256.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH59256.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Contains 2 ANK repeats. CC {ECO:0000256|RuleBase:RU003321}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC059256; AAH59256.1; -; mRNA. DR UniGene; Mm.485843; -. DR ProteinModelPortal; Q6PCM9; -. DR STRING; 10090.ENSMUSP00000078741; -. DR PaxDb; Q6PCM9; -. DR PeptideAtlas; Q6PCM9; -. DR MGI; MGI:97364; Notch2. DR eggNOG; ENOG410IR7G; Eukaryota. DR eggNOG; COG0666; LUCA. DR HOVERGEN; HBG062747; -. DR ChiTaRS; Notch2; mouse. DR GO; GO:0004872; F:receptor activity; IEA:InterPro. DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR020683; Ankyrin_rpt-contain_dom. DR InterPro; IPR024600; DUF3454_notch. DR InterPro; IPR022336; Notch_2. DR Pfam; PF12796; Ank_2; 1. DR Pfam; PF11936; DUF3454; 1. DR PRINTS; PR01985; NOTCH2. DR SMART; SM00248; ANK; 2. DR SMART; SM01334; DUF3454; 1. DR SUPFAM; SSF48403; SSF48403; 1. DR PROSITE; PS50297; ANK_REP_REGION; 1. DR PROSITE; PS50088; ANK_REPEAT; 2. PE 2: Evidence at transcript level; KW ANK repeat {ECO:0000256|RuleBase:RU003321}. FT DOMAIN 7 119 ANK_REP_REGION. {ECO:0000259|PROSITE: FT PS50297}. SQ SEQUENCE 529 AA; 56426 MW; C26EAAB89E68A966 CRC64; MYGKVDSVRG RNLEGMVAEL INCQADVNAV DDHGKSALHW AAAVNNVEAT FLLLKNGANR DMQDNKEETP LFLAAREGSY EAAKILLDHF ANRDITDHMD RLPRDVARDR MHHDIVRLLD EYNVTPSPPG TVLTSALSPV LCGPNRSFLS LKHTPMGKKA RRPNTKSTMP TSLPNLAKEA KDAKGSRRKK CLNEKVQLSE SSVTLSPVDS LESPHTYVSD ATSSPMITSP GILQASPTPL LAAAAPAAPV HTQHALSFSN LHDMQPLAPG ASTVLPSVSQ LLSHHHIAPP GSSSAGSLGR LHPVPVPADW MNRVEMNETQ YSEMFGMVLA PAEGAHPGIA APQSRPPEGK HMSTQREPLP PIVTFQLIPK GSIAQAAGAP QTQSSCPPAV AGPLPSMYQI PEMPRLPSVA FPPTMMPQQE GQVAQTIVPT YHPFPASVGK YPTPPSQHSY ASSNAAERTP SHGGHLQGEH PYLTPSPESP DQWSSSSPHS ASDWSDVTTS PTPGGGGGGQ RGPGTHMSEP PHSNMQVYA //