ID Q6PCM9_MOUSE Unreviewed; 529 AA. AC Q6PCM9; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 11-NOV-2015, entry version 72. DE SubName: Full=Notch2 protein {ECO:0000313|EMBL:AAH59256.1}; GN Name=Notch2 {ECO:0000313|EMBL:AAH59256.1, ECO:0000313|MGI:MGI:97364}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH59256.1}; RN [1] {ECO:0000313|EMBL:AAH59256.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH59256.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH59256.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Contains 2 ANK repeats. CC {ECO:0000256|RuleBase:RU003321}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC059256; AAH59256.1; -; mRNA. DR UniGene; Mm.485843; -. DR ProteinModelPortal; Q6PCM9; -. DR STRING; 10090.ENSMUSP00000078741; -. DR PaxDb; Q6PCM9; -. DR MGI; MGI:97364; Notch2. DR eggNOG; ENOG410IR7G; Eukaryota. DR eggNOG; COG0666; LUCA. DR HOVERGEN; HBG062747; -. DR ChiTaRS; Notch2; mouse. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005929; C:cilium; IDA:MGI. DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI. DR GO; GO:0016020; C:membrane; ISO:MGI. DR GO; GO:0005634; C:nucleus; ISO:MGI. DR GO; GO:0043235; C:receptor complex; ISO:MGI. DR GO; GO:0060413; P:atrial septum morphogenesis; ISO:MGI. DR GO; GO:0046849; P:bone remodeling; ISO:MGI. DR GO; GO:0007050; P:cell cycle arrest; ISO:MGI. DR GO; GO:0016049; P:cell growth; ISO:MGI. DR GO; GO:1990705; P:cholangiocyte proliferation; IMP:MGI. DR GO; GO:0061073; P:ciliary body morphogenesis; IMP:MGI. DR GO; GO:0042742; P:defense response to bacterium; IMP:MGI. DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI. DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI. DR GO; GO:0072574; P:hepatocyte proliferation; IMP:MGI. DR GO; GO:0006959; P:humoral immune response; IGI:MGI. DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI. DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IGI:MGI. DR GO; GO:0072602; P:interleukin-4 secretion; IGI:MGI. DR GO; GO:0035622; P:intrahepatic bile duct development; IMP:MGI. DR GO; GO:0001889; P:liver development; IMP:MGI. DR GO; GO:0072576; P:liver morphogenesis; IMP:MGI. DR GO; GO:0002011; P:morphogenesis of an epithelial sheet; IMP:MGI. DR GO; GO:0035264; P:multicellular organism growth; IMP:MGI. DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IMP:MGI. DR GO; GO:0008285; P:negative regulation of cell proliferation; ISO:MGI. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI. DR GO; GO:0007219; P:Notch signaling pathway; ISO:MGI. DR GO; GO:0060674; P:placenta blood vessel development; IMP:MGI. DR GO; GO:0001890; P:placenta development; IMP:MGI. DR GO; GO:0043065; P:positive regulation of apoptotic process; IGI:MGI. DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IMP:MGI. DR GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISO:MGI. DR GO; GO:0003184; P:pulmonary valve morphogenesis; ISO:MGI. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:MGI. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR020683; Ankyrin_rpt-contain_dom. DR InterPro; IPR024600; DUF3454_notch. DR InterPro; IPR022336; Notch_2. DR Pfam; PF12796; Ank_2; 1. DR Pfam; PF11936; DUF3454; 1. DR PRINTS; PR01985; NOTCH2. DR SMART; SM00248; ANK; 2. DR SUPFAM; SSF48403; SSF48403; 1. DR PROSITE; PS50297; ANK_REP_REGION; 1. DR PROSITE; PS50088; ANK_REPEAT; 2. PE 2: Evidence at transcript level; KW ANK repeat {ECO:0000256|RuleBase:RU003321}. SQ SEQUENCE 529 AA; 56426 MW; C26EAAB89E68A966 CRC64; MYGKVDSVRG RNLEGMVAEL INCQADVNAV DDHGKSALHW AAAVNNVEAT FLLLKNGANR DMQDNKEETP LFLAAREGSY EAAKILLDHF ANRDITDHMD RLPRDVARDR MHHDIVRLLD EYNVTPSPPG TVLTSALSPV LCGPNRSFLS LKHTPMGKKA RRPNTKSTMP TSLPNLAKEA KDAKGSRRKK CLNEKVQLSE SSVTLSPVDS LESPHTYVSD ATSSPMITSP GILQASPTPL LAAAAPAAPV HTQHALSFSN LHDMQPLAPG ASTVLPSVSQ LLSHHHIAPP GSSSAGSLGR LHPVPVPADW MNRVEMNETQ YSEMFGMVLA PAEGAHPGIA APQSRPPEGK HMSTQREPLP PIVTFQLIPK GSIAQAAGAP QTQSSCPPAV AGPLPSMYQI PEMPRLPSVA FPPTMMPQQE GQVAQTIVPT YHPFPASVGK YPTPPSQHSY ASSNAAERTP SHGGHLQGEH PYLTPSPESP DQWSSSSPHS ASDWSDVTTS PTPGGGGGGQ RGPGTHMSEP PHSNMQVYA //