ID Q6PCM9_MOUSE Unreviewed; 529 AA. AC Q6PCM9; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JUL-2024, entry version 100. DE SubName: Full=Notch2 protein {ECO:0000313|EMBL:AAH59256.1}; GN Name=Notch2 {ECO:0000313|EMBL:AAH59256.1, ECO:0000313|MGI:MGI:97364}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH59256.1}; RN [1] {ECO:0000313|EMBL:AAH59256.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH59256.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH59256.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC059256; AAH59256.1; -; mRNA. DR AlphaFoldDB; Q6PCM9; -. DR PeptideAtlas; Q6PCM9; -. DR AGR; MGI:97364; -. DR MGI; MGI:97364; Notch2. DR ChiTaRS; Notch2; mouse. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0043235; C:receptor complex; IEA:InterPro. DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro. DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:TreeGrafter. DR GO; GO:0006915; P:apoptotic process; IEA:InterPro. DR GO; GO:0071228; P:cellular response to tumor cell; IEA:InterPro. DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:TreeGrafter. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1. DR InterPro; IPR050663; Ankyrin-SOCS_Box. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR022336; Notch_2. DR InterPro; IPR024600; Notch_C. DR PANTHER; PTHR24193; ANKYRIN REPEAT PROTEIN; 1. DR PANTHER; PTHR24193:SF127; NOTCH C-TERMINAL DOMAIN-CONTAINING PROTEIN; 1. DR Pfam; PF12796; Ank_2; 1. DR PRINTS; PR01985; NOTCH2. DR SMART; SM00248; ANK; 2. DR SMART; SM01334; DUF3454; 1. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR PROSITE; PS50297; ANK_REP_REGION; 2. DR PROSITE; PS50088; ANK_REPEAT; 2. PE 2: Evidence at transcript level; KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE- KW ProRule:PRU00023}. FT REPEAT 33..65 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 66..98 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT DOMAIN 438..503 FT /note="Notch C-terminal" FT /evidence="ECO:0000259|SMART:SM01334" FT REGION 154..173 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 178..225 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 438..529 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 180..195 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 196..225 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 442..460 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 477..505 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 529 AA; 56426 MW; C26EAAB89E68A966 CRC64; MYGKVDSVRG RNLEGMVAEL INCQADVNAV DDHGKSALHW AAAVNNVEAT FLLLKNGANR DMQDNKEETP LFLAAREGSY EAAKILLDHF ANRDITDHMD RLPRDVARDR MHHDIVRLLD EYNVTPSPPG TVLTSALSPV LCGPNRSFLS LKHTPMGKKA RRPNTKSTMP TSLPNLAKEA KDAKGSRRKK CLNEKVQLSE SSVTLSPVDS LESPHTYVSD ATSSPMITSP GILQASPTPL LAAAAPAAPV HTQHALSFSN LHDMQPLAPG ASTVLPSVSQ LLSHHHIAPP GSSSAGSLGR LHPVPVPADW MNRVEMNETQ YSEMFGMVLA PAEGAHPGIA APQSRPPEGK HMSTQREPLP PIVTFQLIPK GSIAQAAGAP QTQSSCPPAV AGPLPSMYQI PEMPRLPSVA FPPTMMPQQE GQVAQTIVPT YHPFPASVGK YPTPPSQHSY ASSNAAERTP SHGGHLQGEH PYLTPSPESP DQWSSSSPHS ASDWSDVTTS PTPGGGGGGQ RGPGTHMSEP PHSNMQVYA //