ID Q6PC18_BRARE Unreviewed; 184 AA. AC Q6PC18; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 06-MAR-2007, entry version 29. DE Zgc:73144. GN ORFNames=zgc:73144; OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type; TISSUE=Eye; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type; TISSUE=Eye; RG NIH MGC Project; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plasma membrane-associated small GTPase which cycles CC between an active GTP-bound and an inactive GDP-bound state. In CC active state binds to a variety of effector proteins to regulate CC cellular responses. Involved in epithelial cell polarization CC processes. Causes the formation of thin, actin-rich surface CC projections called filopodia (By similarity). CC -!- SUBCELLULAR LOCATION: Cell membrane; lipid-anchor; cytoplasmic CC side (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC059505; AAH59505.1; -; mRNA. DR UniGene; Dr.27137; -. DR HSSP; P10114; 1KAO. DR SMR; Q6PC18; 1-170, 2-171. DR ZFIN; ZDB-GENE-040426-1690; zgc:73144. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. DR InterPro; IPR003577; GTPase_Ras. DR InterPro; IPR013753; Ras. DR InterPro; IPR001806; Ras_trnsfrmng. DR InterPro; IPR005225; Small_GTP_bd. DR Pfam; PF00071; Ras; 1. DR PRINTS; PR00449; RASTRNSFRMNG. DR SMART; SM00173; RAS; 1. DR TIGRFAMs; TIGR00231; small_GTP; 1. KW GTP-binding; Membrane; Nucleotide-binding. SQ SEQUENCE 184 AA; 20581 MW; D4503733FFAA1D97 CRC64; MPQPKSRKIA VLGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKMITVN GQEYHLQLVD TAGQDEYSIF PQTYSIDING YILVYSVTSN KSFEVVKVIH EKLLDMVGKV QVPIMLVGNK KDLHMERVIS CEEGKALAES WNAAFMESSA KENQTAVEVF KRIILEAEKM DGGAPQGRTP CSMM //