ID Q6PC18_DANRE Unreviewed; 184 AA. AC Q6PC18; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 14-DEC-2022, entry version 126. DE SubName: Full=GTP-binding protein Rheb {ECO:0000313|RefSeq:NP_957023.1}; DE SubName: Full=Zgc:73144 {ECO:0000313|EMBL:AAH59505.1}; DE SubName: Full=Zgc:73144 protein {ECO:0000313|EMBL:AAI63610.1}; GN Name=zgc:73144 {ECO:0000313|EMBL:AAH59505.1, GN ECO:0000313|RefSeq:NP_957023.1}; GN OrderedLocusNames=rheb {ECO:0000313|RefSeq:NP_957023.1, GN ECO:0000313|ZFIN:ZDB-GENE-040426-1690}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH59505.1}; RN [1] {ECO:0000313|EMBL:AAH59505.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Wild-type {ECO:0000313|EMBL:AAH59505.1}; RC TISSUE=Eye {ECO:0000313|EMBL:AAH59505.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=19644983; RA Tomasini A.J., Schuler A.D., Zebala J.A., Mayer A.N.; RT "PhotoMorphs: a novel light-activated reagent for controlling gene RT expression in zebrafish."; RL Genesis 47:736-743(2009). RN [3] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=19409617; RA van der Sar A.M., Spaink H.P., Zakrzewska A., Bitter W., Meijer A.H.; RT "Specificity of the zebrafish host transcriptome response to acute and RT chronic mycobacterial infection and the role of innate and adaptive immune RT components."; RL Mol. Immunol. 46:2317-2332(2009). RN [4] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=24837431; RA Kawasaki J., Aegerter S., Fevurly R.D., Mammoto A., Mammoto T., Sahin M., RA Mably J.D., Fishman S.J., Chan J.; RT "RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 RT activity."; RL J. Clin. Invest. 124:2774-2784(2014). RN [5] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [6] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=27189481; RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I., RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y., RA Bobe J.; RT "Gene evolution and gene expression after whole genome duplication in fish: RT the PhyloFish database."; RL BMC Genomics 17:368-368(2016). RN [7] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=27974833; RA Dai Y., Prithiviraj N., Gan J., Zhang X.A., Yan J.; RT "Tissue Extract Fractions from Starfish Undergoing Regeneration Promote RT Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish."; RL Sci. Rep. 6:38693-38693(2016). RN [8] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=29051493; RA Reijnders M.R.F., Kousi M., van Woerden G.M., Klein M., Bralten J., RA Mancini G.M.S., van Essen T., Proietti-Onori M., Smeets E.E.J., RA van Gastel M., Stegmann A.P.A., Stevens S.J.C., Lelieveld S.H., RA Gilissen C., Pfundt R., Tan P.L., Kleefstra T., Franke B., Elgersma Y., RA Katsanis N., Brunner H.G.; RT "Variation in a range of mTOR-related genes associates with intracranial RT volume and intellectual disability."; RL Nat. Commun. 8:1052-1052(2017). RN [9] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=28252024; RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A., RA Choudhary J.S., Emes R.D., Grant S.G.; RT "Evolution of complexity in the zebrafish synapse proteome."; RL Nat. Commun. 8:14613-14613(2017). RN [10] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=29201571; RA Frank D.F., Miller G.W., Connon R.E., Geist J., Lein P.J.; RT "Transcriptomic profiling of mTOR and ryanodine receptor signaling RT molecules in developing zebrafish in the absence and presence of PCB 95."; RL PeerJ 5:e4106-e4106(2017). RN [11] {ECO:0000313|RefSeq:NP_957023.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RX PubMed=29727771; RA Frank D.F., Miller G.W., Harvey D.J., Brander S.M., Geist J., Connon R.E., RA Lein P.J.; RT "Bifenthrin causes transcriptomic alterations in mTOR and ryanodine RT receptor-dependent signaling and delayed hyperactivity in developing RT zebrafish (Danio rerio)."; RL Aquat. Toxicol. 200:50-61(2018). RN [12] {ECO:0000313|RefSeq:NP_957023.1} RP IDENTIFICATION. RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957023.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; CC Evidence={ECO:0000256|ARBA:ARBA00023421}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC059505; AAH59505.1; -; mRNA. DR EMBL; BC163610; AAI63610.1; -; mRNA. DR RefSeq; NP_957023.1; NM_200729.1. DR AlphaFoldDB; Q6PC18; -. DR GeneID; 393702; -. DR KEGG; dre:393702; -. DR CTD; 6009; -. DR ZFIN; ZDB-GENE-040426-1690; rheb. DR OrthoDB; 1320427at2759; -. DR Proteomes; UP000000437; Chromosome 24. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC. DR GO; GO:0019003; F:GDP binding; IBA:GO_Central. DR GO; GO:0005525; F:GTP binding; IBA:GO_Central. DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central. DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central. DR Gene3D; 3.40.50.300; -; 1. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR037586; RHEB. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR001806; Small_GTPase. DR InterPro; IPR020849; Small_GTPase_Ras-type. DR PANTHER; PTHR24070:SF264; GTP-BINDING PROTEIN RHEB; 1. DR PANTHER; PTHR24070; RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY; 1. DR Pfam; PF00071; Ras; 1. DR SMART; SM00174; RHO; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR TIGRFAMs; TIGR00231; small_GTP; 1. DR PROSITE; PS51421; RAS; 1. PE 2: Evidence at transcript level; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. SQ SEQUENCE 184 AA; 20581 MW; D4503733FFAA1D97 CRC64; MPQPKSRKIA VLGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKMITVN GQEYHLQLVD TAGQDEYSIF PQTYSIDING YILVYSVTSN KSFEVVKVIH EKLLDMVGKV QVPIMLVGNK KDLHMERVIS CEEGKALAES WNAAFMESSA KENQTAVEVF KRIILEAEKM DGGAPQGRTP CSMM //