ID Q6P9M2_MOUSE Unreviewed; 906 AA. AC Q6P9M2; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 19-JAN-2022, entry version 119. DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118}; DE Flags: Fragment; GN Name=Gria1 {ECO:0000313|EMBL:AAH60702.1, ECO:0000313|MGI:MGI:95808}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH60702.1}; RN [1] {ECO:0000313|EMBL:AAH60702.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH60702.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH60702.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion CC channel in the central nervous system and plays an important role in CC excitatory synaptic transmission. L-glutamate acts as an excitatory CC neurotransmitter at many synapses in the central nervous system. CC {ECO:0000256|RuleBase:RU367118}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}. Cell CC junction, synapse, postsynaptic cell membrane CC {ECO:0000256|RuleBase:RU367118}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) CC family. {ECO:0000256|RuleBase:RU367118}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC060702; AAH60702.1; -; mRNA. DR PeptideAtlas; Q6P9M2; -. DR PRIDE; Q6P9M2; -. DR MGI; MGI:95808; Gria1. DR OMA; KNVKSYH; -. DR ChiTaRS; Gria1; mouse. DR Genevisible; Q6P9M2; MM. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro. DR InterPro; IPR001828; ANF_lig-bd_rcpt. DR InterPro; IPR019594; Glu/Gly-bd. DR InterPro; IPR001508; Iono_rcpt_met. DR InterPro; IPR001320; Iontro_rcpt. DR InterPro; IPR028082; Peripla_BP_I. DR Pfam; PF01094; ANF_receptor; 1. DR Pfam; PF00060; Lig_chan; 1. DR Pfam; PF10613; Lig_chan-Glu_bd; 1. DR PRINTS; PR00177; NMDARECEPTOR. DR SMART; SM00918; Lig_chan-Glu_bd; 1. DR SMART; SM00079; PBPe; 1. DR SUPFAM; SSF53822; SSF53822; 1. PE 2: Evidence at transcript level; KW Cell junction {ECO:0000256|ARBA:ARBA00022949, KW ECO:0000256|RuleBase:RU367118}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, KW ECO:0000256|RuleBase:RU367118}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU367118}; KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286, KW ECO:0000256|RuleBase:RU367118}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118}; KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257, KW ECO:0000256|RuleBase:RU367118}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU367118}; KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU367118}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU367118}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}. FT SIGNAL 1..17 FT /evidence="ECO:0000256|RuleBase:RU367118" FT CHAIN 18..906 FT /note="Glutamate receptor" FT /evidence="ECO:0000256|RuleBase:RU367118" FT /id="PRO_5027159299" FT TRANSMEM 534..556 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367118" FT TRANSMEM 617..639 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367118" FT TRANSMEM 807..829 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367118" FT DOMAIN 407..782 FT /note="PBPe" FT /evidence="ECO:0000259|SMART:SM00079" FT DOMAIN 417..482 FT /note="Lig_chan-Glu_bd" FT /evidence="ECO:0000259|SMART:SM00918" FT REGION 856..880 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAH60702.1" SQ SEQUENCE 906 AA; 101462 MW; 91B98C386FA85C99 CRC64; PYIFAFFCTG FLGAVVGANF PNNIQIGGLF PNQQSQEHAA FRFALSQLTE PPKLLPQIDI VNISDSFEMT YRFCSQFSKG VYAIFGFYER RTVNMLTSFC GALHVCFITP SFPVDTSNQF VLQLRPELQE ALISIIDHYK WQTFVYIYDA DRGLSVLQRV LDTAAEKNWQ VTAVNILTTT EEGYRMLFQD LEKKKERLVV VDCESERLNA ILGQIVKLEK NGIGYHYILA NLGFMDIDLN KFKESGANVT GFQLVNYTDT IPARIMQQWR TSDARDHTRV DWKRPKYTSA LTYDGVKVMA EAFQSLRRQR IDISRRGNAG DCLANPAVPW GQGIDIQRAL QQVRFEGLTG NVQFNEKGRR TNYTLHVIEM KHDGIRKIGY WNEDDKFVPA ATDAQAGGDN SSVQNRTYIV TTILEDPYVM LKKNANQFEG NDRYEGYCVE LAAEIAKHVG YSYRLEIVSD GKYGARDPDT KAWNGMVGEL VYGRADVAVA PLTITLVREE VIDFSKPFMS LGISIMIKKP QKSKPGVFSF LDPLAYEIWM CIVFAYIGVS VVLFLVSRFS PYEWHSEEFE EGRDQTTSDQ SNEFGIFNSL WFSLGAFMQQ GCDISPRSLS GRIVGGVWWF FTLIIISSYT ANLAAFLTVE RMVSPIESAE DLAKQTEIAY GTLEAGSTKE FFRRSKIAVF EKMWTYMKSA EPSVFVRTTE EGMIRVRKSK GKYAYLLEST MNEYIEQRKP CDTMKVGGNL DSKGYGIATP KGSALRNPVN LAVLKLNEQG LLDKLKNKWW YDKGECGSGG GDSKDKTSAL SLSNVAGVFY ILIGGLGLAM LVALIEFCYK SRSESKRMKG FCLIPQQSIN EAIRTSTLPR NSGAGASGGS GSGENGRVVS QDFPKSMQSI PCMSHSSGMP LGATGL //