ID Q6P8N8_MOUSE Unreviewed; 620 AA. AC Q6P8N8; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 22-APR-2020, entry version 135. DE SubName: Full=ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial {ECO:0000313|Ensembl:ENSMUSP00000109455}; DE SubName: Full=Caseinolytic peptidase X (E.coli) {ECO:0000313|EMBL:AAH61153.1}; GN Name=Clpx {ECO:0000313|EMBL:AAH61153.1, GN ECO:0000313|Ensembl:ENSMUSP00000109455, ECO:0000313|MGI:MGI:1346017}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH61153.1}; RN [1] {ECO:0000313|EMBL:AAH61153.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAH61153.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000109455, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109455, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000109455} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109455}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC110235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC061153; AAH61153.1; -; mRNA. DR RefSeq; NP_001037854.1; NM_001044389.2. DR Antibodypedia; 51984; 89 antibodies. DR Ensembl; ENSMUST00000113824; ENSMUSP00000109455; ENSMUSG00000015357. DR GeneID; 270166; -. DR UCSC; uc009qdc.2; mouse. DR CTD; 10845; -. DR MGI; MGI:1346017; Clpx. DR eggNOG; KOG0745; Eukaryota. DR eggNOG; COG1219; LUCA. DR GeneTree; ENSGT00390000017625; -. DR HOGENOM; CLU_014218_0_1_1; -. DR OMA; WGVRRFH; -. DR ChiTaRS; Clpx; mouse. DR Proteomes; UP000000589; Chromosome 9. DR Bgee; ENSMUSG00000015357; Expressed in liver and 270 other tissues. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro. DR GO; GO:0006457; P:protein folding; IEA:InterPro. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR003959; ATPase_AAA_core. DR InterPro; IPR019489; Clp_ATPase_C. DR InterPro; IPR004487; Clp_protease_ATP-bd_su_ClpX. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR11262; PTHR11262; 1. DR Pfam; PF07724; AAA_2; 1. DR Pfam; PF10431; ClpB_D2-small; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM01086; ClpB_D2-small; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0000213|EPD:Q6P8N8, KW ECO:0000213|MaxQB:Q6P8N8, ECO:0000213|PeptideAtlas:Q6P8N8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 272..423 FT /note="AAA" FT /evidence="ECO:0000259|SMART:SM00382" FT DOMAIN 496..590 FT /note="ClpB_D2-small" FT /evidence="ECO:0000259|SMART:SM01086" FT REGION 69..102 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 585..620 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 81..101 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 585..600 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 620 AA; 67336 MW; 44D82B9F5AE6F81C CRC64; MSSCGACTCG AAAARLLTTS LTSAQRGISC GRIHVPVLGR LGTTLDAQAL RRAPLRTFSE TPAYFASKDG ANKDGSGDGN KKSVTEGSSK KSGSGNSGKG GNQLRCPKCG DLCTHVETFV SSTRFVKCEK CHHFFVVLSE ADSKKSIIKE PESAAEAVKL AFQQKPPPPP KKIYNYLDKY VVGQSFAKKV LSVAVYNHYK RIYNNIPANL RQQAEAEKQT SLTPRELLQI AGISPHGNAL GASMQQQVNQ QMPQEKRGGE VLDSSQDDIK LEKSNILLLG PTGSGKTLLA QTLAKCLDVP FAICDCTTLT QAGYVGEDIE SVIAKLLQDA NYNVEKAQQG IVFLDEVDKI GSVPGIHQLR DVGGEGVQQG LLKLLEGTIV NVPEKNSRKL RGETVQVDTT NVLFVASGAF NGLDRIISRR KNEKYLGFGT PSNLGKGRRA AAAADLANRS GESNTHQDIE EKDRLLRHVE ARDLIEFGMI PEFVGRLPVV VPLHSLDEKT LVQILTEPRN AVIPQYQALF SMDKCELNVT EDALKAIARL ALERKTGARG LRSIMEKLLL EPMFEVPNSD IVCVEVDKEV VEGKKEPGYI RAPSKESSEE EYDSGVEEDG WPRQADAANS //