ID Q6P5P0_MOUSE Unreviewed; 153 AA. AC Q6P5P0; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JUN-2015, entry version 85. DE SubName: Full=P2X purinoceptor 7 {ECO:0000313|Ensembl:ENSMUSP00000083425}; DE SubName: Full=Purinergic receptor P2X, ligand-gated ion channel, 7 {ECO:0000313|EMBL:AAH62808.1}; GN Name=P2rx7 {ECO:0000313|EMBL:AAH62808.1, GN ECO:0000313|Ensembl:ENSMUSP00000083425, ECO:0000313|MGI:MGI:1339957}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH62808.1}; RN [1] {ECO:0000313|EMBL:AAH62808.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Mammary gland {ECO:0000313|EMBL:AAH62808.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000083425, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000083425, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000083425} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000083425}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC114632; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC062808; AAH62808.1; -; mRNA. DR RefSeq; NP_001033976.1; NM_001038887.1. DR UniGene; Mm.42026; -. DR STRING; 10090.ENSMUSP00000098303; -. DR Ensembl; ENSMUST00000086247; ENSMUSP00000083425; ENSMUSG00000029468. DR GeneID; 18439; -. DR KEGG; mmu:18439; -. DR UCSC; uc008zlo.1; mouse. DR CTD; 5027; -. DR MGI; MGI:1339957; P2rx7. DR GeneTree; ENSGT00390000016028; -. DR HOGENOM; HOG000199495; -. DR HOVERGEN; HBG062516; -. DR KO; K05220; -. DR NextBio; 294114; -. DR Proteomes; UP000000589; Chromosome 5. DR GO; GO:0005911; C:cell-cell junction; IDA:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005639; C:integral component of nuclear inner membrane; IBA:GO_Central. DR GO; GO:0005887; C:integral component of plasma membrane; IMP:MGI. DR GO; GO:0016020; C:membrane; IDA:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0043025; C:neuronal cell body; IDA:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0045202; C:synapse; IDA:MGI. DR GO; GO:0005524; F:ATP binding; IMP:MGI. DR GO; GO:0015267; F:channel activity; IMP:MGI. DR GO; GO:0004931; F:extracellular ATP-gated cation channel activity; IMP:MGI. DR GO; GO:0001530; F:lipopolysaccharide binding; IDA:MGI. DR GO; GO:0001614; F:purinergic nucleotide receptor activity; ISO:MGI. DR GO; GO:0004872; F:receptor activity; IMP:MGI. DR GO; GO:0000187; P:activation of MAPK activity; IMP:MGI. DR GO; GO:0032060; P:bleb assembly; IMP:MGI. DR GO; GO:0006816; P:calcium ion transport; IMP:MGI. DR GO; GO:0006812; P:cation transport; IMP:MGI. DR GO; GO:0000902; P:cell morphogenesis; IMP:MGI. DR GO; GO:0006884; P:cell volume homeostasis; IDA:MGI. DR GO; GO:0071359; P:cellular response to dsRNA; IMP:MGI. DR GO; GO:0031668; P:cellular response to extracellular stimulus; IMP:MGI. DR GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI. DR GO; GO:0046513; P:ceramide biosynthetic process; IDA:MGI. DR GO; GO:0032963; P:collagen metabolic process; IMP:MGI. DR GO; GO:0019835; P:cytolysis; IDA:MGI. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI. DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IMP:MGI. DR GO; GO:0010467; P:gene expression; IMP:MGI. DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI. DR GO; GO:0006954; P:inflammatory response; IMP:MGI. DR GO; GO:0006900; P:membrane budding; IMP:MGI. DR GO; GO:0051899; P:membrane depolarization; ISO:MGI. DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; IMP:MGI. DR GO; GO:0007005; P:mitochondrion organization; IDA:MGI. DR GO; GO:0044254; P:multicellular organismal protein catabolic process; IDA:MGI. DR GO; GO:0043132; P:NAD transport; IMP:MGI. DR GO; GO:0045779; P:negative regulation of bone resorption; IMP:MGI. DR GO; GO:0043409; P:negative regulation of MAPK cascade; IDA:MGI. DR GO; GO:0001845; P:phagolysosome assembly; IMP:MGI. DR GO; GO:0006649; P:phospholipid transfer to membrane; IMP:MGI. DR GO; GO:0045332; P:phospholipid translocation; IDA:MGI. DR GO; GO:0007009; P:plasma membrane organization; IDA:MGI. DR GO; GO:0046931; P:pore complex assembly; IMP:MGI. DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:MGI. DR GO; GO:0030501; P:positive regulation of bone mineralization; IMP:MGI. DR GO; GO:0010524; P:positive regulation of calcium ion transport into cytosol; ISO:MGI. DR GO; GO:0043085; P:positive regulation of catalytic activity; IMP:MGI. DR GO; GO:0050715; P:positive regulation of cytokine secretion; IMP:MGI. DR GO; GO:0014054; P:positive regulation of gamma-aminobutyric acid secretion; IMP:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI. DR GO; GO:0014049; P:positive regulation of glutamate secretion; IMP:MGI. DR GO; GO:0045821; P:positive regulation of glycolytic process; ISO:MGI. DR GO; GO:0050717; P:positive regulation of interleukin-1 alpha secretion; IMP:MGI. DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IMP:MGI. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IMP:MGI. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IMP:MGI. DR GO; GO:0070230; P:positive regulation of lymphocyte apoptotic process; IMP:MGI. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IMP:MGI. DR GO; GO:0051901; P:positive regulation of mitochondrial depolarization; IMP:MGI. DR GO; GO:0045778; P:positive regulation of ossification; IMP:MGI. DR GO; GO:0032308; P:positive regulation of prostaglandin secretion; IMP:MGI. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:MGI. DR GO; GO:0050714; P:positive regulation of protein secretion; IDA:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IMP:MGI. DR GO; GO:0012501; P:programmed cell death; IDA:MGI. DR GO; GO:0051259; P:protein oligomerization; IDA:MGI. DR GO; GO:0006468; P:protein phosphorylation; IMP:MGI. DR GO; GO:0016485; P:protein processing; IMP:MGI. DR GO; GO:0035590; P:purinergic nucleotide receptor signaling pathway; ISO:MGI. DR GO; GO:0072593; P:reactive oxygen species metabolic process; IMP:MGI. DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:MGI. DR GO; GO:0033198; P:response to ATP; IDA:MGI. DR GO; GO:0009617; P:response to bacterium; IMP:MGI. DR GO; GO:0051592; P:response to calcium ion; IDA:MGI. DR GO; GO:0042493; P:response to drug; IMP:MGI. DR GO; GO:0051602; P:response to electrical stimulus; IMP:MGI. DR GO; GO:0034405; P:response to fluid shear stress; IMP:MGI. DR GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI. DR GO; GO:0009612; P:response to mechanical stimulus; IMP:MGI. DR GO; GO:0014070; P:response to organic cyclic compound; IDA:MGI. DR GO; GO:0010033; P:response to organic substance; IMP:MGI. DR GO; GO:0010043; P:response to zinc ion; IMP:MGI. DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI. DR GO; GO:0016079; P:synaptic vesicle exocytosis; IMP:MGI. DR GO; GO:0043029; P:T cell homeostasis; IMP:MGI. DR GO; GO:0042098; P:T cell proliferation; IMP:MGI. DR Gene3D; 2.60.490.10; -; 1. DR InterPro; IPR003050; P2X7_purnocptor. DR InterPro; IPR027309; P2X_extracellular_dom. DR InterPro; IPR001429; P2X_purnocptor. DR PANTHER; PTHR10125; PTHR10125; 1. DR PANTHER; PTHR10125:SF13; PTHR10125:SF13; 1. DR Pfam; PF00864; P2X_receptor; 1. DR PRINTS; PR01314; P2X7RECEPTOR. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q6P5P0}; KW Receptor {ECO:0000313|EMBL:AAH62808.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 153 AA; 17199 MW; 05917407370B40CE CRC64; MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP EDLSNLQESN QTSKPLLRNP RAKKEEGLSL ELA //