ID Q6P5P0_MOUSE Unreviewed; 153 AA. AC Q6P5P0; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 18-SEP-2013, entry version 69. DE SubName: Full=P2X purinoceptor 7; DE SubName: Full=Purinergic receptor P2X, ligand-gated ion channel, 7; GN Name=P2rx7; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] RP IDENTIFICATION. RC STRAIN=C57BL/6J; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC114632; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC062808; AAH62808.1; -; mRNA. DR IPI; IPI00459581; -. DR RefSeq; NP_001033928.1; NM_001038839.1. DR RefSeq; NP_001033976.1; NM_001038887.1. DR UniGene; Mm.42026; -. DR Ensembl; ENSMUST00000086247; ENSMUSP00000083425; ENSMUSG00000029468. DR GeneID; 18439; -. DR KEGG; mmu:18439; -. DR UCSC; uc008zlo.1; mouse. DR CTD; 5027; -. DR MGI; MGI:1339957; P2rx7. DR GeneTree; ENSGT00390000016028; -. DR HOGENOM; HOG000199495; -. DR HOVERGEN; HBG062516; -. DR KO; K05220; -. DR NextBio; 294114; -. DR Genevestigator; Q6P5P0; -. DR GO; GO:0005911; C:cell-cell junction; IDA:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005887; C:integral to plasma membrane; IMP:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0043025; C:neuronal cell body; IDA:MGI. DR GO; GO:0005524; F:ATP binding; IMP:MGI. DR GO; GO:0004931; F:extracellular ATP-gated cation channel activity; IMP:MGI. DR GO; GO:0001530; F:lipopolysaccharide binding; IDA:MGI. DR GO; GO:0001614; F:purinergic nucleotide receptor activity; IBA:RefGenome. DR GO; GO:0000187; P:activation of MAPK activity; IMP:MGI. DR GO; GO:0032060; P:bleb assembly; IMP:MGI. DR GO; GO:0000902; P:cell morphogenesis; IMP:MGI. DR GO; GO:0006884; P:cell volume homeostasis; IDA:MGI. DR GO; GO:0031668; P:cellular response to extracellular stimulus; IMP:MGI. DR GO; GO:0046513; P:ceramide biosynthetic process; IDA:MGI. DR GO; GO:0032963; P:collagen metabolic process; IMP:MGI. DR GO; GO:0019835; P:cytolysis; IDA:MGI. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI. DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI. DR GO; GO:0006954; P:inflammatory response; IMP:MGI. DR GO; GO:0006900; P:membrane budding; IMP:MGI. DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; IMP:MGI. DR GO; GO:0007005; P:mitochondrion organization; IDA:MGI. DR GO; GO:0044254; P:multicellular organismal protein catabolic process; IDA:MGI. DR GO; GO:0043132; P:NAD transport; IMP:MGI. DR GO; GO:0045779; P:negative regulation of bone resorption; IMP:MGI. DR GO; GO:0043409; P:negative regulation of MAPK cascade; IDA:MGI. DR GO; GO:0001845; P:phagolysosome assembly; IMP:MGI. DR GO; GO:0006649; P:phospholipid transfer to membrane; IMP:MGI. DR GO; GO:0045332; P:phospholipid translocation; IDA:MGI. DR GO; GO:0007009; P:plasma membrane organization; IDA:MGI. DR GO; GO:0046931; P:pore complex assembly; IMP:MGI. DR GO; GO:0030501; P:positive regulation of bone mineralization; IMP:MGI. DR GO; GO:0014054; P:positive regulation of gamma-aminobutyric acid secretion; IMP:MGI. DR GO; GO:0014049; P:positive regulation of glutamate secretion; IMP:MGI. DR GO; GO:0050717; P:positive regulation of interleukin-1 alpha secretion; IMP:MGI. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IMP:MGI. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IMP:MGI. DR GO; GO:0070230; P:positive regulation of lymphocyte apoptotic process; IMP:MGI. DR GO; GO:0051901; P:positive regulation of mitochondrial depolarization; IMP:MGI. DR GO; GO:0032308; P:positive regulation of prostaglandin secretion; IMP:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IMP:MGI. DR GO; GO:0051259; P:protein oligomerization; IDA:MGI. DR GO; GO:0006468; P:protein phosphorylation; IMP:MGI. DR GO; GO:0016485; P:protein processing; IMP:MGI. DR GO; GO:0072593; P:reactive oxygen species metabolic process; IMP:MGI. DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:MGI. DR GO; GO:0033198; P:response to ATP; IDA:MGI. DR GO; GO:0051592; P:response to calcium ion; IDA:MGI. DR GO; GO:0042493; P:response to drug; IMP:MGI. DR GO; GO:0051602; P:response to electrical stimulus; IMP:MGI. DR GO; GO:0034405; P:response to fluid shear stress; IMP:MGI. DR GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI. DR GO; GO:0009612; P:response to mechanical stimulus; IMP:MGI. DR GO; GO:0010043; P:response to zinc ion; IMP:MGI. DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI. DR GO; GO:0016079; P:synaptic vesicle exocytosis; IMP:MGI. DR GO; GO:0043029; P:T cell homeostasis; IMP:MGI. DR GO; GO:0042098; P:T cell proliferation; IMP:MGI. DR Gene3D; 2.60.490.10; -; 1. DR InterPro; IPR003050; P2X7_purnocptor. DR InterPro; IPR027309; P2X_extracellular_dom. DR InterPro; IPR001429; P2X_purnocptor. DR PANTHER; PTHR10125; PTHR10125; 1. DR PANTHER; PTHR10125:SF13; PTHR10125:SF13; 1. DR Pfam; PF00864; P2X_receptor; 1. DR PRINTS; PR01314; P2X7RECEPTOR. PE 2: Evidence at transcript level; KW Complete proteome; Receptor; Reference proteome. SQ SEQUENCE 153 AA; 17199 MW; 05917407370B40CE CRC64; MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP EDLSNLQESN QTSKPLLRNP RAKKEEGLSL ELA //