ID Q6P5P0_MOUSE Unreviewed; 153 AA. AC Q6P5P0; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 01-SEP-2009, entry version 32. DE SubName: Full=Purinergic receptor P2X, ligand-gated ion channel, 7; GN Name=P2rx7; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC062808; AAH62808.1; -; mRNA. DR IPI; IPI00459581; -. DR RefSeq; NP_001033928.1; -. DR RefSeq; NP_001033976.1; -. DR UniGene; Mm.42026; -. DR STRING; Q6P5P0; -. DR Ensembl; ENSMUST00000086247; ENSMUSP00000083425; ENSMUSG00000029468; Mus musculus. DR Ensembl; ENSMUST00000100737; ENSMUSP00000098303; ENSMUSG00000029468; Mus musculus. DR GeneID; 18439; -. DR UCSC; uc008zlo.1; mouse. DR CTD; 18439; -. DR MGI; MGI:1339957; P2rx7. DR HOVERGEN; Q6P5P0; -. DR OMA; Q6P5P0; EIVEKEM. DR NextBio; 294114; -. DR ArrayExpress; Q6P5P0; -. DR Bgee; Q6P5P0; -. DR GO; GO:0043025; C:cell soma; IDA:MGI. DR GO; GO:0005911; C:cell-cell junction; IDA:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0005887; C:integral to plasma membrane; IMP:MGI. DR GO; GO:0031594; C:neuromuscular junction; IDA:MGI. DR GO; GO:0019717; C:synaptosome; IDA:MGI. DR GO; GO:0005524; F:ATP binding; IMP:MGI. DR GO; GO:0004931; F:ATP-gated cation channel activity; IMP:MGI. DR GO; GO:0001530; F:lipopolysaccharide binding; IDA:MGI. DR GO; GO:0005515; F:protein binding; IPI:MGI. DR GO; GO:0004872; F:receptor activity; IMP:MGI. DR GO; GO:0000187; P:activation of MAPK activity; IMP:MGI. DR GO; GO:0032060; P:bleb formation; IMP:MGI. DR GO; GO:0000902; P:cell morphogenesis; IMP:MGI. DR GO; GO:0006884; P:cell volume homeostasis; IDA:MGI. DR GO; GO:0031668; P:cellular response to extracellular stimulus; IMP:MGI. DR GO; GO:0046513; P:ceramide biosynthetic process; IDA:MGI. DR GO; GO:0032963; P:collagen metabolic process; IMP:MGI. DR GO; GO:0019835; P:cytolysis; IDA:MGI. DR GO; GO:0019835; P:cytolysis; IMP:MGI. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI. DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI. DR GO; GO:0006954; P:inflammatory response; IMP:MGI. DR GO; GO:0006900; P:membrane budding; IMP:MGI. DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; IMP:MGI. DR GO; GO:0007005; P:mitochondrion organization; IDA:MGI. DR GO; GO:0044254; P:multicellular organismal protein catabolic ...; IDA:MGI. DR GO; GO:0043132; P:NAD transport; IMP:MGI. DR GO; GO:0045779; P:negative regulation of bone resorption; IMP:MGI. DR GO; GO:0043409; P:negative regulation of MAPKKK cascade; IDA:MGI. DR GO; GO:0006800; P:oxygen and reactive oxygen species metaboli...; IMP:MGI. DR GO; GO:0001845; P:phagolysosome formation; IMP:MGI. DR GO; GO:0006649; P:phospholipid transfer to membrane; IMP:MGI. DR GO; GO:0045332; P:phospholipid translocation; IDA:MGI. DR GO; GO:0007009; P:plasma membrane organization; IDA:MGI. DR GO; GO:0046931; P:pore complex biogenesis; IMP:MGI. DR GO; GO:0043065; P:positive regulation of apoptosis; IMP:MGI. DR GO; GO:0030501; P:positive regulation of bone mineralization; IMP:MGI. DR GO; GO:0014054; P:positive regulation of gamma-aminobutyric a...; IMP:MGI. DR GO; GO:0014049; P:positive regulation of glutamate secretion; IMP:MGI. DR GO; GO:0050717; P:positive regulation of interleukin-1 alpha ...; IMP:MGI. DR GO; GO:0032731; P:positive regulation of interleukin-1 beta p...; IMP:MGI. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta s...; IMP:MGI. DR GO; GO:0032755; P:positive regulation of interleukin-6 produc...; IMP:MGI. DR GO; GO:0043410; P:positive regulation of MAPKKK cascade; IMP:MGI. DR GO; GO:0051901; P:positive regulation of mitochondrial depola...; IMP:MGI. DR GO; GO:0032308; P:positive regulation of prostaglandin secretion; IMP:MGI. DR GO; GO:0001934; P:positive regulation of protein amino acid p...; IMP:MGI. DR GO; GO:0001916; P:positive regulation of T cell mediated cyto...; IMP:MGI. DR GO; GO:0051259; P:protein oligomerization; IDA:MGI. DR GO; GO:0016485; P:protein processing; IMP:MGI. DR GO; GO:0051209; P:release of sequestered calcium ion into cyt...; IMP:MGI. DR GO; GO:0033198; P:response to ATP; IDA:MGI. DR GO; GO:0033198; P:response to ATP; IMP:MGI. DR GO; GO:0051592; P:response to calcium ion; IDA:MGI. DR GO; GO:0051592; P:response to calcium ion; IMP:MGI. DR GO; GO:0042493; P:response to drug; IMP:MGI. DR GO; GO:0051602; P:response to electrical stimulus; IMP:MGI. DR GO; GO:0034405; P:response to fluid shear stress; IMP:MGI. DR GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI. DR GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI. DR GO; GO:0009612; P:response to mechanical stimulus; IMP:MGI. DR GO; GO:0014070; P:response to organic cyclic substance; IDA:MGI. DR GO; GO:0051789; P:response to protein stimulus; IDA:MGI. DR GO; GO:0010043; P:response to zinc ion; IMP:MGI. DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI. DR GO; GO:0016079; P:synaptic vesicle exocytosis; IMP:MGI. DR GO; GO:0043029; P:T cell homeostasis; IMP:MGI. DR GO; GO:0042098; P:T cell proliferation; IMP:MGI. DR InterPro; IPR003050; P2X7_purnocptor. DR InterPro; IPR001429; P2X_purnocptor. DR PANTHER; PTHR10125; ATP_P2X_rcpt; 1. DR Pfam; PF00864; P2X_receptor; 1. DR PRINTS; PR01314; P2X7RECEPTOR. PE 2: Evidence at transcript level; KW Receptor. SQ SEQUENCE 153 AA; 17199 MW; 05917407370B40CE CRC64; MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP EDLSNLQESN QTSKPLLRNP RAKKEEGLSL ELA //