ID Q6P5P0_MOUSE Unreviewed; 153 AA. AC Q6P5P0; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 02-DEC-2020, entry version 124. DE SubName: Full=P2X purinoceptor 7 {ECO:0000313|Ensembl:ENSMUSP00000083425}; DE SubName: Full=Purinergic receptor P2X, ligand-gated ion channel, 7 {ECO:0000313|EMBL:AAH62808.1}; GN Name=P2rx7 {ECO:0000313|EMBL:AAH62808.1, GN ECO:0000313|Ensembl:ENSMUSP00000083425, ECO:0000313|MGI:MGI:1339957}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH62808.1}; RN [1] {ECO:0000313|EMBL:AAH62808.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Mammary gland {ECO:0000313|EMBL:AAH62808.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000083425, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000083425, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000083425} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000083425}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the P2X receptor family. CC {ECO:0000256|ARBA:ARBA00009848}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC114632; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC062808; AAH62808.1; -; mRNA. DR RefSeq; NP_001033976.1; NM_001038887.1. DR Antibodypedia; 19042; 432 antibodies. DR Ensembl; ENSMUST00000086247; ENSMUSP00000083425; ENSMUSG00000029468. DR GeneID; 18439; -. DR UCSC; uc008zlo.1; mouse. DR CTD; 5027; -. DR MGI; MGI:1339957; P2rx7. DR GeneTree; ENSGT01010000222290; -. DR HOGENOM; CLU_146810_0_0_1; -. DR BioGRID-ORCS; 18439; 0 hits in 17 CRISPR screens. DR ChiTaRS; P2rx7; mouse. DR Proteomes; UP000000589; Chromosome 5. DR Bgee; ENSMUSG00000029468; Expressed in bone marrow macrophage and 153 other tissues. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0005216; F:ion channel activity; IEA:InterPro. DR GO; GO:0001614; F:purinergic nucleotide receptor activity; IEA:InterPro. DR Gene3D; 2.60.490.10; -; 1. DR InterPro; IPR003050; P2X7_purinoceptor. DR InterPro; IPR027309; P2X_extracellular_dom_sf. DR PANTHER; PTHR10125:SF13; PTHR10125:SF13; 1. DR PRINTS; PR01314; P2X7RECEPTOR. PE 1: Evidence at protein level; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Proteomics identification {ECO:0000213|EPD:Q6P5P0, KW ECO:0000213|MaxQB:Q6P5P0, ECO:0000213|PeptideAtlas:Q6P5P0}; KW Receptor {ECO:0000313|EMBL:AAH62808.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Transport {ECO:0000256|ARBA:ARBA00022448}. FT REGION 129..153 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 138..153 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 153 AA; 17199 MW; 05917407370B40CE CRC64; MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP EDLSNLQESN QTSKPLLRNP RAKKEEGLSL ELA //