ID   FRMD5_MOUSE             Reviewed;         517 AA.
AC   Q6P5H6; B0R0I9; Q6PFH6; Q8C0K0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   02-MAR-2010, entry version 50.
DE   RecName: Full=FERM domain-containing protein 5;
GN   Name=Frmd5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC   STRAIN=C57BL/6J; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC   STRAIN=C57BL/6; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q6P5H6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P5H6-2; Sequence=VSP_019983, VSP_019984;
CC       Name=3;
CC         IsoId=Q6P5H6-3; Sequence=VSP_019983, VSP_019985;
CC       Name=4;
CC         IsoId=Q6P5H6-4; Sequence=VSP_019983, VSP_019986;
CC   -!- SIMILARITY: Contains 1 FERM domain.
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DR   EMBL; AK030883; BAC27170.1; -; mRNA.
DR   EMBL; AL928678; CAQ12956.1; -; Genomic_DNA.
DR   EMBL; BC057549; AAH57549.1; -; mRNA.
DR   EMBL; BC062889; AAH62889.1; -; mRNA.
DR   IPI; IPI00223843; -.
DR   IPI; IPI00466728; -.
DR   IPI; IPI00755067; -.
DR   IPI; IPI00885573; -.
DR   RefSeq; NP_766261.2; -.
DR   UniGene; Mm.121514; -.
DR   UniGene; Mm.428057; -.
DR   SMR; Q6P5H6; 15-347.
DR   PhosphoSite; Q6P5H6; -.
DR   PRIDE; Q6P5H6; -.
DR   Ensembl; ENSMUST00000110590; ENSMUSP00000106220; ENSMUSG00000027238; Mus musculus.
DR   Ensembl; ENSMUST00000110591; ENSMUSP00000106221; ENSMUSG00000027238; Mus musculus.
DR   Ensembl; ENSMUST00000110593; ENSMUSP00000106223; ENSMUSG00000027238; Mus musculus.
DR   GeneID; 228564; -.
DR   KEGG; mmu:228564; -.
DR   UCSC; uc008lzl.1; mouse.
DR   UCSC; uc008lzm.1; mouse.
DR   CTD; 228564; -.
DR   MGI; MGI:2442557; Frmd5.
DR   HOVERGEN; HBG057180; -.
DR   PhylomeDB; Q6P5H6; -.
DR   NextBio; 379036; -.
DR   ArrayExpress; Q6P5H6; -.
DR   Bgee; Q6P5H6; -.
DR   CleanEx; MM_FRMD5; -.
DR   Genevestigator; Q6P5H6; -.
DR   GermOnline; ENSMUSG00000027238; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0019898; C:extrinsic to membrane; IEA:InterPro.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR019750; Band_41_sg.
DR   InterPro; IPR000798; Ez/rad/moesin.
DR   InterPro; IPR014847; FERM-adjacent.
DR   InterPro; IPR014352; FERM/acyl-CoA_bd_prot_3-hlx.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH_type.
DR   Gene3D; G3DSA:1.20.80.10; ACBP; 1.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SUPFAM; SSF47031; FERM_3-hlx; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS00661; FERM_2; FALSE_NEG.
DR   PROSITE; PS50057; FERM_3; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing.
FT   CHAIN         1    517       FERM domain-containing protein 5.
FT                                /FTId=PRO_0000247447.
FT   DOMAIN       17    298       FERM.
FT   VAR_SEQ       1     89       Missing (in isoform 2, isoform 3 and
FT                                isoform 4).
FT                                /FTId=VSP_019983.
FT   VAR_SEQ     494    517       RVHLKGPQLQQQQWKGWGKSVPLD -> VNKFVLSVLRLLL
FT                                VTMGLLFVLLLLLIILTESDLDVAFFRDIRQTPEFEQFHYQ
FT                                YFCPLRRWFACKIRSVVSLLIDT (in isoform 2).
FT                                /FTId=VSP_019984.
FT   VAR_SEQ     494    517       RVHLKGPQLQQQQWKGWGKSVPLD -> MQERDRSEEGIEK
FT                                EQRPWKGPGSTKQDL (in isoform 3).
FT                                /FTId=VSP_019985.
FT   VAR_SEQ     494    517       RVHLKGPQLQQQQWKGWGKSVPLD -> AMVCLQNPLSGEP
FT                                AN (in isoform 4).
FT                                /FTId=VSP_019986.
SQ   SEQUENCE   517 AA;  58583 MW;  064722C4016B4BD5 CRC64;
     MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL NLLEKDYFGI
     RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD PAALKEEITR YLVFLQIKRD
     LYHGRLLCKT SDAALLAAYI LQAEIGDYDP GKHPEGYSSK FQFFPKHSEK LEKKIAEIHK
     TELSGQTPAT SELNFLRKAQ TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF
     IKWNEVTKLK FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS
     QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR SCPSITHGPR
     LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSSSHGDT FLPHVRSSRA DSNERVAVIA
     DEAYSPADSV LPTPVAEHSL ELMLLSRQIN GATCSIEEEK ESEASTPTAT EAEALGGELR
     ALCQGHGGSE QEQRVHLKGP QLQQQQWKGW GKSVPLD
//