ID   Z280C_MOUSE             Reviewed;         742 AA.
AC   Q6P3Y5; B1AU28; B1AU29; Q6ZPM2; Q8K145;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   05-FEB-2025, entry version 149.
DE   RecName: Full=Zinc finger protein 280C;
DE   AltName: Full=Suppressor of hairy wing homolog 3;
GN   Name=Znf280c; Synonyms=Kiaa1584, Suhw3, Zfp280c;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Embryonic tail;
RX   PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:167-180(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May function as a transcription factor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6P3Y5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P3Y5-2; Sequence=VSP_017620, VSP_017621;
CC       Name=3;
CC         IsoId=Q6P3Y5-3; Sequence=VSP_017619;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC98209.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK129399; BAC98209.1; ALT_INIT; mRNA.
DR   EMBL; AK141491; BAE24700.1; -; mRNA.
DR   EMBL; AL669901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC028839; AAH28839.1; -; mRNA.
DR   EMBL; BC051397; AAH51397.1; -; mRNA.
DR   EMBL; BC063775; AAH63775.1; -; mRNA.
DR   CCDS; CCDS30111.1; -. [Q6P3Y5-1]
DR   CCDS; CCDS53064.1; -. [Q6P3Y5-3]
DR   CCDS; CCDS53065.1; -. [Q6P3Y5-2]
DR   RefSeq; NP_001160120.1; NM_001166648.1. [Q6P3Y5-1]
DR   RefSeq; NP_001160121.1; NM_001166649.1. [Q6P3Y5-3]
DR   RefSeq; NP_001160122.1; NM_001166650.1. [Q6P3Y5-2]
DR   RefSeq; NP_705760.2; NM_153532.3. [Q6P3Y5-1]
DR   RefSeq; XP_006541521.1; XM_006541458.3. [Q6P3Y5-1]
DR   RefSeq; XP_006541522.1; XM_006541459.3. [Q6P3Y5-1]
DR   RefSeq; XP_006541524.1; XM_006541461.3.
DR   RefSeq; XP_006541528.1; XM_006541465.3.
DR   AlphaFoldDB; Q6P3Y5; -.
DR   BioGRID; 229030; 4.
DR   STRING; 10090.ENSMUSP00000075933; -.
DR   GlyGen; Q6P3Y5; 1 site, 1 N-linked glycan (1 site).
DR   iPTMnet; Q6P3Y5; -.
DR   PhosphoSitePlus; Q6P3Y5; -.
DR   jPOST; Q6P3Y5; -.
DR   PaxDb; 10090-ENSMUSP00000075933; -.
DR   PeptideAtlas; Q6P3Y5; -.
DR   ProteomicsDB; 275255; -. [Q6P3Y5-1]
DR   ProteomicsDB; 275256; -. [Q6P3Y5-2]
DR   ProteomicsDB; 275257; -. [Q6P3Y5-3]
DR   Pumba; Q6P3Y5; -.
DR   Antibodypedia; 30167; 80 antibodies from 22 providers.
DR   DNASU; 208968; -.
DR   Ensembl; ENSMUST00000072292.12; ENSMUSP00000072138.6; ENSMUSG00000036916.14. [Q6P3Y5-3]
DR   Ensembl; ENSMUST00000076635.13; ENSMUSP00000075933.7; ENSMUSG00000036916.14. [Q6P3Y5-1]
DR   Ensembl; ENSMUST00000088898.11; ENSMUSP00000086288.5; ENSMUSG00000036916.14. [Q6P3Y5-1]
DR   Ensembl; ENSMUST00000114940.9; ENSMUSP00000110590.3; ENSMUSG00000036916.14. [Q6P3Y5-2]
DR   GeneID; 208968; -.
DR   KEGG; mmu:208968; -.
DR   UCSC; uc009tcj.1; mouse. [Q6P3Y5-2]
DR   UCSC; uc009tck.1; mouse. [Q6P3Y5-1]
DR   UCSC; uc009tcm.2; mouse. [Q6P3Y5-3]
DR   AGR; MGI:2387585; -.
DR   CTD; 208968; -.
DR   MGI; MGI:2387585; Zfp280c.
DR   VEuPathDB; HostDB:ENSMUSG00000036916; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162128; -.
DR   HOGENOM; CLU_010097_1_0_1; -.
DR   InParanoid; Q6P3Y5; -.
DR   OMA; PKCNIQF; -.
DR   OrthoDB; 10032537at2759; -.
DR   PhylomeDB; Q6P3Y5; -.
DR   TreeFam; TF331707; -.
DR   BioGRID-ORCS; 208968; 1 hit in 79 CRISPR screens.
DR   ChiTaRS; Zfp280c; mouse.
DR   PRO; PR:Q6P3Y5; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q6P3Y5; protein.
DR   Bgee; ENSMUSG00000036916; Expressed in humerus cartilage element and 242 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   FunFam; 3.30.160.60:FF:000298; zinc finger protein 280D isoform X1; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   InterPro; IPR025243; DUF4195.
DR   InterPro; IPR050527; Snail/Krueppel_Znf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24388; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24388:SF62; ZINC FINGER PROTEIN 280C; 1.
DR   Pfam; PF13836; DUF4195; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN           1..742
FT                   /note="Zinc finger protein 280C"
FT                   /id="PRO_0000227976"
FT   ZN_FING         323..345
FT                   /note="C2H2-type 1"
FT   ZN_FING         360..383
FT                   /note="C2H2-type 2"
FT   ZN_FING         390..413
FT                   /note="C2H2-type 3"
FT   ZN_FING         420..443
FT                   /note="C2H2-type 4"
FT   ZN_FING         477..499
FT                   /note="C2H2-type 5"
FT   REGION          138..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..608
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        10
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        23
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        42
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        65
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        85
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        123
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        135
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        180
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        186
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        193
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   CROSSLNK        580
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8ND82"
FT   VAR_SEQ         11..19
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14621295"
FT                   /id="VSP_017619"
FT   VAR_SEQ         686..693
FT                   /note="RGITLVCL -> SYRKSRNF (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_017620"
FT   VAR_SEQ         694..742
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_017621"
SQ   SEQUENCE   742 AA;  83146 MW;  04A82F753CAD6C10 CRC64;
     MDKDNSVQEK GLFLSSWKLD NSKMAELFME CEEEELEPWQ QKVEESQSKD DDDELIFVGE
     ISSSKPAISN ILNRCSPGSS SKGLKNGSFN PAISNIFKPT SQHYRNPSSN ALVALPSFHP
     ALKSSESSDG QTVSKLDFTK TSPQEDSGAC SVSQSDSTQD IPSSNILQPR TGVDQTLGLK
     HPSTSKVNSV NPKKPKTSAS ISETRPCSSS SSQTAPSGAS SQTVLSNVNT SSVQSAPGSS
     SLRSCPKCNV KFRLLDPLKC HMKRCCPDMI NKFLETLKSE NSKAVSKATT DSDKEKLIML
     VSDFYYGRHE GTIEESQKTH TTFKCFSCTK VLKNNIRFMN HMKHHLELEK QNNETWESHT
     TCQHCYRQYP NPFQLQCHIE STHTPHDFST ICKICELSFE TEHMLLQHMK DTHKPGEMPY
     ICQVCQFRSS IFSDVETHFR SSHENTKNLL CPFCLKVSRM ATPYMNHYMR HQKKGIYRCP
     KCRLQFLTSK EKTEHKLEHR TFIKPKELEG LPPGTKVIIR ASLGSSQSRA SSPPSSTIPS
     TSLQLSVPKS KSTTTKNNSK VSANKATTTS PQTVATTTGK PSASKPGTGT TKSKAKPSYK
     QKRQRTRKNK FSIDLKNLRC HQGSHMCIEC RSKIKDFSSH FSTHINCDFC KYTTNCNKAF
     TNHMSSHNDH PSKQLYIFKK QSRARRGITL VCLKCDFLAD TSGLDRMAKH LNQRKTHTCQ
     VVIENVTERA VTSESASDGL FK
//