ID Q6NZR1_MOUSE Unreviewed; 353 AA. AC Q6NZR1; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JUN-2015, entry version 96. DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500}; GN Name=Wnt7b {ECO:0000313|EMBL:AAH66003.1, GN ECO:0000313|Ensembl:ENSMUSP00000105051, ECO:0000313|MGI:MGI:98962}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH66003.1}; RN [1] {ECO:0000313|EMBL:AAH66003.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH66003.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH66003.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000105051, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105051, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000105051} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000105051}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Ligand for members of the frizzled family of seven CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000256|RuleBase:RU003500}. CC -!- SIMILARITY: Belongs to the Wnt family. CC {ECO:0000256|RuleBase:RU003500}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC115763; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC066003; AAH66003.1; -; mRNA. DR RefSeq; NP_001157106.1; NM_001163634.1. DR UniGene; Mm.306946; -. DR STRING; 10090.ENSMUSP00000105051; -. DR Ensembl; ENSMUST00000109424; ENSMUSP00000105051; ENSMUSG00000022382. DR GeneID; 22422; -. DR KEGG; mmu:22422; -. DR UCSC; uc007xde.2; mouse. DR CTD; 7477; -. DR MGI; MGI:98962; Wnt7b. DR GeneTree; ENSGT00760000118943; -. DR HOGENOM; HOG000039528; -. DR HOVERGEN; HBG001595; -. DR KO; K00572; -. DR OMA; AMLCGRI; -. DR TreeFam; TF105310; -. DR NextBio; 302857; -. DR Proteomes; UP000000589; Chromosome 15. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell. DR GO; GO:0005109; F:frizzled binding; IPI:MGI. DR GO; GO:0007257; P:activation of JUN kinase activity; IEA:Ensembl. DR GO; GO:0060033; P:anatomical structure regression; IMP:MGI. DR GO; GO:0001525; P:angiogenesis; IMP:MGI. DR GO; GO:1902262; P:apoptotic process involved in patterning of blood vessels; IMP:MGI. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IDA:MGI. DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central. DR GO; GO:0044237; P:cellular metabolic process; IMP:MGI. DR GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl. DR GO; GO:0022009; P:central nervous system vasculogenesis; IGI:MGI. DR GO; GO:0060710; P:chorio-allantoic fusion; IMP:MGI. DR GO; GO:0060560; P:developmental growth involved in morphogenesis; IMP:MGI. DR GO; GO:0048568; P:embryonic organ development; IMP:MGI. DR GO; GO:0060669; P:embryonic placenta morphogenesis; IMP:MGI. DR GO; GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; IMP:MGI. DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl. DR GO; GO:0021871; P:forebrain regionalization; IEA:Ensembl. DR GO; GO:0042592; P:homeostatic process; IMP:MGI. DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI. DR GO; GO:0072061; P:inner medullary collecting duct development; IMP:MGI. DR GO; GO:0060482; P:lobar bronchus development; IMP:MGI. DR GO; GO:0030324; P:lung development; IMP:MGI. DR GO; GO:0060428; P:lung epithelium development; IMP:MGI. DR GO; GO:0060425; P:lung morphogenesis; IMP:MGI. DR GO; GO:0060484; P:lung-associated mesenchyme development; IMP:MGI. DR GO; GO:0061180; P:mammary gland epithelium development; IEA:Ensembl. DR GO; GO:0072205; P:metanephric collecting duct development; IMP:MGI. DR GO; GO:0072207; P:metanephric epithelium development; IMP:MGI. DR GO; GO:0072236; P:metanephric loop of Henle development; IMP:MGI. DR GO; GO:0003338; P:metanephros morphogenesis; IMP:MGI. DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:MGI. DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central. DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl. DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI. DR GO; GO:0072060; P:outer medullary collecting duct development; IMP:MGI. DR GO; GO:0032364; P:oxygen homeostasis; IMP:MGI. DR GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI. DR GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central. DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:MGI. DR GO; GO:0032536; P:regulation of cell projection size; IEA:Ensembl. DR GO; GO:0072053; P:renal inner medulla development; IMP:MGI. DR GO; GO:0072054; P:renal outer medulla development; IMP:MGI. DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl. DR GO; GO:0051145; P:smooth muscle cell differentiation; IMP:MGI. DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl. DR GO; GO:0050808; P:synapse organization; IGI:MGI. DR GO; GO:0060535; P:trachea cartilage morphogenesis; IMP:MGI. DR GO; GO:0001944; P:vasculature development; IMP:MGI. DR GO; GO:0016055; P:Wnt signaling pathway; IMP:MGI. DR InterPro; IPR005817; Wnt. DR InterPro; IPR013300; Wnt7. DR InterPro; IPR018161; Wnt_CS. DR PANTHER; PTHR12027; PTHR12027; 1. DR Pfam; PF00110; wnt; 1. DR PRINTS; PR01891; WNT7PROTEIN. DR PRINTS; PR01349; WNTPROTEIN. DR SMART; SM00097; WNT1; 1. DR PROSITE; PS00246; WNT1; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Developmental protein {ECO:0000256|RuleBase:RU003500, KW ECO:0000256|SAAS:SAAS00083909}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00083920}; KW Extracellular matrix {ECO:0000256|SAAS:SAAS00083931}; KW Proteomics identification {ECO:0000213|MaxQB:Q6NZR1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Secreted {ECO:0000256|SAAS:SAAS00083928}; KW Wnt signaling pathway {ECO:0000256|RuleBase:RU003500, KW ECO:0000256|SAAS:SAAS00083917}. SQ SEQUENCE 353 AA; 39336 MW; 2B57FC1FA67A60D6 CRC64; MLLLSPRSAL VSVYCPQIFL LLSSGSYLAL SSVVALGANI ICNKIPGLAP RQRAICQSRP DAIIVIGEGA QMGIDECQHQ FRFGRWNCSA LGEKTVFGQE LRVGSREAAF TYAITAAGVA HAVTAACSQG NLSNCGCDRE KQGYYNQAEG WKWGGCSADV RYGIDFSRRF VDAREIKKNA RRLMNLHNNE AGRKVLEDRM KLECKCHGVS GSCTTKTCWT TLPKFREVGH LLKEKYNAAV QVEVVRASRL RQPTFLRIKQ LRSYQKPMET DLVYIEKSPN YCEEDAATGS VGTQGRLCNR TSPGADGCDT MCCGRGYNTH QYTKVWQCNC KFHWCCFVKC NTCSERTEVF TCK //