ID Q6NZR1_MOUSE Unreviewed; 353 AA. AC Q6NZR1; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 06-MAR-2013, entry version 75. DE RecName: Full=Protein Wnt; GN Name=Wnt7b; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] RP IDENTIFICATION. RC STRAIN=C57BL/6J; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Ligand for members of the frizzled family of seven CC transmembrane receptors (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix (By similarity). CC -!- SIMILARITY: Belongs to the Wnt family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC115763; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC066003; AAH66003.1; -; mRNA. DR IPI; IPI00758004; -. DR RefSeq; NP_001157106.1; NM_001163634.1. DR UniGene; Mm.306946; -. DR STRING; Q6NZR1; -. DR Ensembl; ENSMUST00000109424; ENSMUSP00000105051; ENSMUSG00000022382. DR GeneID; 22422; -. DR KEGG; mmu:22422; -. DR UCSC; uc007xde.2; mouse. DR CTD; 7477; -. DR MGI; MGI:98962; Wnt7b. DR GeneTree; ENSGT00700000104317; -. DR HOGENOM; HOG000039528; -. DR HOVERGEN; HBG001595; -. DR InParanoid; Q6NZR1; -. DR KO; K00572; -. DR OMA; DSAMSRD; -. DR NextBio; 302857; -. DR Genevestigator; Q6NZR1; -. DR GO; GO:0005615; C:extracellular space; IBA:RefGenome. DR GO; GO:0005886; C:plasma membrane; IBA:RefGenome. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell. DR GO; GO:0005102; F:receptor binding; TAS:MGI. DR GO; GO:0007257; P:activation of JUN kinase activity; IBA:RefGenome. DR GO; GO:0060033; P:anatomical structure regression; IMP:MGI. DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:RefGenome. DR GO; GO:0009798; P:axis specification; IBA:RefGenome. DR GO; GO:0007409; P:axonogenesis; IBA:RefGenome. DR GO; GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI. DR GO; GO:0007267; P:cell-cell signaling; TAS:MGI. DR GO; GO:0071300; P:cellular response to retinoic acid; IEA:Compara. DR GO; GO:0022009; P:central nervous system vasculogenesis; IGI:MGI. DR GO; GO:0060710; P:chorio-allantoic fusion; IMP:MGI. DR GO; GO:0060560; P:developmental growth involved in morphogenesis; IMP:MGI. DR GO; GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; IMP:MGI. DR GO; GO:0048144; P:fibroblast proliferation; IEA:Compara. DR GO; GO:0021871; P:forebrain regionalization; IEA:Compara. DR GO; GO:0006917; P:induction of apoptosis; IMP:MGI. DR GO; GO:0072061; P:inner medullary collecting duct development; IMP:MGI. DR GO; GO:0060482; P:lobar bronchus development; IMP:MGI. DR GO; GO:0060428; P:lung epithelium development; IMP:MGI. DR GO; GO:0060425; P:lung morphogenesis; IMP:MGI. DR GO; GO:0060484; P:lung-associated mesenchyme development; IMP:MGI. DR GO; GO:0061180; P:mammary gland epithelium development; IEA:Compara. DR GO; GO:0072205; P:metanephric collecting duct development; IMP:MGI. DR GO; GO:0072236; P:metanephric loop of Henle development; IMP:MGI. DR GO; GO:0003338; P:metanephros morphogenesis; IMP:MGI. DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:MGI. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome. DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI. DR GO; GO:0072060; P:outer medullary collecting duct development; IMP:MGI. DR GO; GO:0032364; P:oxygen homeostasis; IMP:MGI. DR GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. DR GO; GO:0046330; P:positive regulation of JNK cascade; IBA:RefGenome. DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome. DR GO; GO:0072053; P:renal inner medulla development; IMP:MGI. DR GO; GO:0072054; P:renal outer medulla development; IMP:MGI. DR GO; GO:0051145; P:smooth muscle cell differentiation; IMP:MGI. DR GO; GO:0072089; P:stem cell proliferation; IEA:Compara. DR GO; GO:0050808; P:synapse organization; IGI:MGI. DR GO; GO:0060535; P:trachea cartilage morphogenesis; IMP:MGI. DR InterPro; IPR005817; Wnt. DR InterPro; IPR013300; Wnt7. DR InterPro; IPR018161; Wnt_CS. DR PANTHER; PTHR12027; PTHR12027; 1. DR PANTHER; PTHR12027:SF22; PTHR12027:SF22; 1. DR Pfam; PF00110; wnt; 1. DR PRINTS; PR01891; WNT7PROTEIN. DR PRINTS; PR01349; WNTPROTEIN. DR SMART; SM00097; WNT1; 1. DR PROSITE; PS00246; WNT1; 1. PE 2: Evidence at transcript level; KW Complete proteome; Developmental protein; Extracellular matrix; KW Reference proteome; Secreted; Wnt signaling pathway. SQ SEQUENCE 353 AA; 39336 MW; 2B57FC1FA67A60D6 CRC64; MLLLSPRSAL VSVYCPQIFL LLSSGSYLAL SSVVALGANI ICNKIPGLAP RQRAICQSRP DAIIVIGEGA QMGIDECQHQ FRFGRWNCSA LGEKTVFGQE LRVGSREAAF TYAITAAGVA HAVTAACSQG NLSNCGCDRE KQGYYNQAEG WKWGGCSADV RYGIDFSRRF VDAREIKKNA RRLMNLHNNE AGRKVLEDRM KLECKCHGVS GSCTTKTCWT TLPKFREVGH LLKEKYNAAV QVEVVRASRL RQPTFLRIKQ LRSYQKPMET DLVYIEKSPN YCEEDAATGS VGTQGRLCNR TSPGADGCDT MCCGRGYNTH QYTKVWQCNC KFHWCCFVKC NTCSERTEVF TCK //