ID Q6NZR1_MOUSE Unreviewed; 353 AA. AC Q6NZR1; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 05-APR-2011, entry version 58. DE RecName: Full=Protein Wnt; GN Name=Wnt7b; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Ligand for members of the frizzled family of seven CC transmembrane receptors (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix (By similarity). CC -!- SIMILARITY: Belongs to the Wnt family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC066003; AAH66003.1; -; mRNA. DR IPI; IPI00758004; -. DR RefSeq; NP_001157106.1; NM_001163634.1. DR UniGene; Mm.306946; -. DR STRING; Q6NZR1; -. DR PRIDE; Q6NZR1; -. DR Ensembl; ENSMUST00000109424; ENSMUSP00000105051; ENSMUSG00000022382. DR GeneID; 22422; -. DR KEGG; mmu:22422; -. DR UCSC; uc007xde.1; mouse. DR CTD; 22422; -. DR MGI; MGI:98962; Wnt7b. DR GeneTree; ENSGT00600000084153; -. DR HOGENOM; HBG446188; -. DR HOVERGEN; HBG001595; -. DR InParanoid; Q6NZR1; -. DR OMA; AIRECEN; -. DR ArrayExpress; Q6NZR1; -. DR Bgee; Q6NZR1; -. DR Genevestigator; Q6NZR1; -. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell. DR GO; GO:0005109; F:frizzled binding; IPI:MGI. DR GO; GO:0004871; F:signal transducer activity; IEA:InterPro. DR GO; GO:0060033; P:anatomical structure regression; IMP:MGI. DR GO; GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI. DR GO; GO:0007267; P:cell-cell signaling; TAS:MGI. DR GO; GO:0044237; P:cellular metabolic process; IMP:MGI. DR GO; GO:0022009; P:central nervous system vasculogenesis; IGI:MGI. DR GO; GO:0060710; P:chorio-allantoic fusion; IMP:MGI. DR GO; GO:0060560; P:developmental growth involved in morphogenesis; IMP:MGI. DR GO; GO:0060669; P:embryonic placenta morphogenesis; IMP:MGI. DR GO; GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; IMP:MGI. DR GO; GO:0006917; P:induction of apoptosis; IMP:MGI. DR GO; GO:0072061; P:inner medullary collecting duct development; IMP:MGI. DR GO; GO:0060482; P:lobar bronchus development; IMP:MGI. DR GO; GO:0060428; P:lung epithelium development; IMP:MGI. DR GO; GO:0060425; P:lung morphogenesis; IMP:MGI. DR GO; GO:0060484; P:lung-associated mesenchyme development; IMP:MGI. DR GO; GO:0072205; P:metanephric collecting duct development; IMP:MGI. DR GO; GO:0072236; P:metanephric loop of Henle development; IMP:MGI. DR GO; GO:0003338; P:metanephros morphogenesis; IMP:MGI. DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:MGI. DR GO; GO:0042475; P:odontogenesis of dentine-containing tooth; IMP:MGI. DR GO; GO:0072060; P:outer medullary collecting duct development; IMP:MGI. DR GO; GO:0032364; P:oxygen homeostasis; IMP:MGI. DR GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI. DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:MGI. DR GO; GO:0072053; P:renal inner medulla development; IMP:MGI. DR GO; GO:0072054; P:renal outer medulla development; IMP:MGI. DR GO; GO:0051145; P:smooth muscle cell differentiation; IMP:MGI. DR GO; GO:0050808; P:synapse organization; IGI:MGI. DR GO; GO:0060535; P:trachea cartilage morphogenesis; IMP:MGI. DR GO; GO:0007223; P:Wnt receptor signaling pathway, calcium modulating pathway; IEA:InterPro. DR InterPro; IPR013300; Wnt7. DR InterPro; IPR005816; Wnt_grthfactor. DR InterPro; IPR018161; Wnt_grthfactor_CS. DR InterPro; IPR005817; Wnt_SF. DR PANTHER; PTHR12027; Wnt; 1. DR Pfam; PF00110; wnt; 1. DR PRINTS; PR01891; WNT7PROTEIN. DR PRINTS; PR01349; WNTPROTEIN. DR SMART; SM00097; WNT1; 1. DR PROSITE; PS00246; WNT1; 1. PE 2: Evidence at transcript level; KW Developmental protein; Extracellular matrix; Wnt signaling pathway. SQ SEQUENCE 353 AA; 39336 MW; 2B57FC1FA67A60D6 CRC64; MLLLSPRSAL VSVYCPQIFL LLSSGSYLAL SSVVALGANI ICNKIPGLAP RQRAICQSRP DAIIVIGEGA QMGIDECQHQ FRFGRWNCSA LGEKTVFGQE LRVGSREAAF TYAITAAGVA HAVTAACSQG NLSNCGCDRE KQGYYNQAEG WKWGGCSADV RYGIDFSRRF VDAREIKKNA RRLMNLHNNE AGRKVLEDRM KLECKCHGVS GSCTTKTCWT TLPKFREVGH LLKEKYNAAV QVEVVRASRL RQPTFLRIKQ LRSYQKPMET DLVYIEKSPN YCEEDAATGS VGTQGRLCNR TSPGADGCDT MCCGRGYNTH QYTKVWQCNC KFHWCCFVKC NTCSERTEVF TCK //