ID Q6NZR1_MOUSE Unreviewed; 353 AA. AC Q6NZR1; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 03-MAY-2023, entry version 144. DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500}; GN Name=Wnt7b {ECO:0000313|EMBL:AAH66003.1, GN ECO:0000313|Ensembl:ENSMUSP00000155014.2, ECO:0000313|MGI:MGI:98962}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH66003.1}; RN [1] {ECO:0000313|EMBL:AAH66003.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH66003.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH66003.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000155014.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155014.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000155014.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155014.2}; RG Ensembl; RL Submitted (JAN-2023) to UniProtKB. CC -!- FUNCTION: Ligand for members of the frizzled family of seven CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}. CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683, CC ECO:0000256|RuleBase:RU003500}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC066003; AAH66003.1; -; mRNA. DR RefSeq; NP_001157106.1; NM_001163634.1. DR ProteomicsDB; 333309; -. DR Antibodypedia; 27975; 103 antibodies from 22 providers. DR DNASU; 22422; -. DR Ensembl; ENSMUST00000229191.2; ENSMUSP00000155014.2; ENSMUSG00000022382.16. DR GeneID; 22422; -. DR UCSC; uc007xde.2; mouse. DR AGR; MGI:98962; -. DR CTD; 7477; -. DR MGI; MGI:98962; Wnt7b. DR VEuPathDB; HostDB:ENSMUSG00000022382; -. DR GeneTree; ENSGT00940000158861; -. DR OrthoDB; 2874082at2759; -. DR TreeFam; TF105310; -. DR BioGRID-ORCS; 22422; 2 hits in 78 CRISPR screens. DR ChiTaRS; Wnt7b; mouse. DR Proteomes; UP000000589; Chromosome 15. DR Bgee; ENSMUSG00000022382; Expressed in cortical plate and 241 other tissues. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro. DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt. DR GO; GO:0030154; P:cell differentiation; IEA:UniProt. DR GO; GO:0048731; P:system development; IEA:UniProt. DR GO; GO:0009888; P:tissue development; IEA:UniProt. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR CDD; cd19350; wnt_Wnt7b; 1. DR Gene3D; 3.30.2460.20; -; 1. DR InterPro; IPR005817; Wnt. DR InterPro; IPR013300; Wnt7. DR InterPro; IPR043158; Wnt_C. DR InterPro; IPR018161; Wnt_CS. DR PANTHER; PTHR12027:SF73; PROTEIN WNT-7B; 1. DR PANTHER; PTHR12027; WNT RELATED; 1. DR Pfam; PF00110; wnt; 1. DR PRINTS; PR01891; WNT7PROTEIN. DR PRINTS; PR01349; WNTPROTEIN. DR SMART; SM00097; WNT1; 1. DR PROSITE; PS00246; WNT1; 1. PE 1: Evidence at protein level; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473, KW ECO:0000256|RuleBase:RU003500}; KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Proteomics identification {ECO:0007829|MaxQB:Q6NZR1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, KW ECO:0000256|RuleBase:RU003500}. SQ SEQUENCE 353 AA; 39336 MW; 2B57FC1FA67A60D6 CRC64; MLLLSPRSAL VSVYCPQIFL LLSSGSYLAL SSVVALGANI ICNKIPGLAP RQRAICQSRP DAIIVIGEGA QMGIDECQHQ FRFGRWNCSA LGEKTVFGQE LRVGSREAAF TYAITAAGVA HAVTAACSQG NLSNCGCDRE KQGYYNQAEG WKWGGCSADV RYGIDFSRRF VDAREIKKNA RRLMNLHNNE AGRKVLEDRM KLECKCHGVS GSCTTKTCWT TLPKFREVGH LLKEKYNAAV QVEVVRASRL RQPTFLRIKQ LRSYQKPMET DLVYIEKSPN YCEEDAATGS VGTQGRLCNR TSPGADGCDT MCCGRGYNTH QYTKVWQCNC KFHWCCFVKC NTCSERTEVF TCK //