ID Q6NZR1_MOUSE Unreviewed; 353 AA. AC Q6NZR1; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 16-OCT-2019, entry version 126. DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500}; GN Name=Wnt7b {ECO:0000313|EMBL:AAH66003.1, GN ECO:0000313|Ensembl:ENSMUSP00000155014, ECO:0000313|MGI:MGI:98962}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH66003.1}; RN [1] {ECO:0000313|EMBL:AAH66003.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH66003.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH66003.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000155014, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155014, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000155014} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155014}; RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC -!- FUNCTION: Ligand for members of the frizzled family of seven CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000256|RuleBase:RU003500, CC ECO:0000256|SAAS:SAAS00681827}. CC -!- SIMILARITY: Belongs to the Wnt family. CC {ECO:0000256|RuleBase:RU003500, ECO:0000256|SAAS:SAAS00681828}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC115763; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC066003; AAH66003.1; -; mRNA. DR RefSeq; NP_001157106.1; NM_001163634.1. DR Ensembl; ENSMUST00000229191; ENSMUSP00000155014; ENSMUSG00000022382. DR GeneID; 22422; -. DR UCSC; uc007xde.2; mouse. DR CTD; 7477; -. DR MGI; MGI:98962; Wnt7b. DR eggNOG; KOG3913; Eukaryota. DR eggNOG; ENOG410XQZ1; LUCA. DR GeneTree; ENSGT00940000158861; -. DR HOGENOM; HOG000039528; -. DR OrthoDB; 745245at2759; -. DR TreeFam; TF105310; -. DR ChiTaRS; Wnt7b; mouse. DR Proteomes; UP000000589; Chromosome 15. DR Bgee; ENSMUSG00000022382; Expressed in 312 organ(s), highest expression level in testis. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0048018; F:receptor ligand activity; IEA:Ensembl. DR GO; GO:0007257; P:activation of JUN kinase activity; IEA:Ensembl. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl. DR GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl. DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl. DR GO; GO:0021871; P:forebrain regionalization; IEA:Ensembl. DR GO; GO:0061180; P:mammary gland epithelium development; IEA:Ensembl. DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl. DR GO; GO:0032536; P:regulation of cell projection size; IEA:Ensembl. DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl. DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl. DR InterPro; IPR005817; Wnt. DR InterPro; IPR013300; Wnt7. DR InterPro; IPR018161; Wnt_CS. DR PANTHER; PTHR12027; PTHR12027; 1. DR Pfam; PF00110; wnt; 1. DR PRINTS; PR01891; WNT7PROTEIN. DR PRINTS; PR01349; WNTPROTEIN. DR SMART; SM00097; WNT1; 1. DR PROSITE; PS00246; WNT1; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Developmental protein {ECO:0000256|RuleBase:RU003500, KW ECO:0000256|SAAS:SAAS00083909}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00083920}; KW Extracellular matrix {ECO:0000256|SAAS:SAAS00083931}; KW Proteomics identification {ECO:0000213|MaxQB:Q6NZR1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Secreted {ECO:0000256|SAAS:SAAS00083928}; KW Wnt signaling pathway {ECO:0000256|RuleBase:RU003500, KW ECO:0000256|SAAS:SAAS00083917}. SQ SEQUENCE 353 AA; 39336 MW; 2B57FC1FA67A60D6 CRC64; MLLLSPRSAL VSVYCPQIFL LLSSGSYLAL SSVVALGANI ICNKIPGLAP RQRAICQSRP DAIIVIGEGA QMGIDECQHQ FRFGRWNCSA LGEKTVFGQE LRVGSREAAF TYAITAAGVA HAVTAACSQG NLSNCGCDRE KQGYYNQAEG WKWGGCSADV RYGIDFSRRF VDAREIKKNA RRLMNLHNNE AGRKVLEDRM KLECKCHGVS GSCTTKTCWT TLPKFREVGH LLKEKYNAAV QVEVVRASRL RQPTFLRIKQ LRSYQKPMET DLVYIEKSPN YCEEDAATGS VGTQGRLCNR TSPGADGCDT MCCGRGYNTH QYTKVWQCNC KFHWCCFVKC NTCSERTEVF TCK //