ID Q6NZ93_HUMAN Unreviewed; 153 AA. AC Q6NZ93; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 29-SEP-2021, entry version 82. DE RecName: Full=Interleukin-2 {ECO:0000256|ARBA:ARBA00019453, ECO:0000256|RuleBase:RU363134}; DE Short=IL-2 {ECO:0000256|RuleBase:RU363134}; GN Name=IL2 {ECO:0000256|RuleBase:RU363134, ECO:0000313|EMBL:AAH66254.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH66254.1}; RN [1] {ECO:0000313|EMBL:AAH66254.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Produced by T-cells in response to antigenic or mitogenic CC stimulation, this protein is required for T-cell proliferation and CC other activities crucial to regulation of the immune response. CC {ECO:0000256|RuleBase:RU363134}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|RuleBase:RU363134}. CC -!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000256|ARBA:ARBA00006949, CC ECO:0000256|RuleBase:RU363134}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC066254; AAH66254.1; -; mRNA. DR SMR; Q6NZ93; -. DR OMA; NGVNNYE; -. DR ChiTaRS; IL2; human. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005134; F:interleukin-2 receptor binding; IEA:InterPro. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR000779; IL-2. DR InterPro; IPR030477; IL-2_CS. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR SMART; SM00189; IL2; 1. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130, KW ECO:0000256|RuleBase:RU363134}; Coiled coil {ECO:0000256|SAM:Coils}; KW Cytokine {ECO:0000256|RuleBase:RU363134}; KW Disulfide bond {ECO:0000256|RuleBase:RU363134}; KW Growth factor {ECO:0000256|RuleBase:RU363134}; KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|RuleBase:RU363134}; KW Secreted {ECO:0000256|RuleBase:RU363134}; KW Signal {ECO:0000256|RuleBase:RU363134}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|RuleBase:RU363134" FT CHAIN 21..153 FT /note="Interleukin-2" FT /evidence="ECO:0000256|RuleBase:RU363134" FT /id="PRO_5009031738" FT COILED 76..96 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 153 AA; 17598 MW; 1942F50F25960E88 CRC64; MYRMQLLSCI ALSLALVANS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT //