ID Q6NZ93_HUMAN Unreviewed; 153 AA. AC Q6NZ93; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 15-MAR-2017, entry version 68. DE RecName: Full=Interleukin-2 {ECO:0000256|RuleBase:RU363134}; DE Short=IL-2 {ECO:0000256|RuleBase:RU363134}; GN Name=IL2 {ECO:0000256|RuleBase:RU363134, ECO:0000313|EMBL:AAH66254.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH66254.1}; RN [1] {ECO:0000313|EMBL:AAH66254.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Produced by T-cells in response to antigenic or CC mitogenic stimulation, this protein is required for T-cell CC proliferation and other activities crucial to regulation of the CC immune response. {ECO:0000256|RuleBase:RU363134}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU363134}. CC -!- SIMILARITY: Belongs to the IL-2 family. CC {ECO:0000256|RuleBase:RU363134}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC066254; AAH66254.1; -; mRNA. DR UniGene; Hs.89679; -. DR ProteinModelPortal; Q6NZ93; -. DR STRING; 9606.ENSP00000226730; -. DR PaxDb; Q6NZ93; -. DR eggNOG; ENOG410J049; Eukaryota. DR eggNOG; ENOG41119SF; LUCA. DR HOVERGEN; HBG007496; -. DR ChiTaRS; IL2; human. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR012351; 4_helix_cytokine_core. DR InterPro; IPR000779; IL-2. DR InterPro; IPR030477; IL-2_CS. DR PANTHER; PTHR10078:SF32; PTHR10078:SF32; 1. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR ProDom; PD003649; Interleukin-2; 1. DR SMART; SM00189; IL2; 1. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|RuleBase:RU363134}; KW Cytokine {ECO:0000256|RuleBase:RU363134}; KW Disulfide bond {ECO:0000256|RuleBase:RU363134}; KW Growth factor {ECO:0000256|RuleBase:RU363134}; KW Immunity {ECO:0000256|RuleBase:RU363134}; KW Secreted {ECO:0000256|RuleBase:RU363134}; KW Signal {ECO:0000256|RuleBase:RU363134}. FT SIGNAL 1 20 {ECO:0000256|RuleBase:RU363134}. FT CHAIN 21 153 Interleukin-2. {ECO:0000256|RuleBase: FT RU363134}. FT /FTId=PRO_5009031738. SQ SEQUENCE 153 AA; 17598 MW; 1942F50F25960E88 CRC64; MYRMQLLSCI ALSLALVANS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT //