ID Q6NZ93_HUMAN Unreviewed; 153 AA. AC Q6NZ93; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 10-JUL-2007, entry version 28. DE Interleukin 2. GN Name=IL2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=PCR rescued clones; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=PCR rescued clones; RG NIH MGC Project; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC066254; AAH66254.1; -; mRNA. DR UniGene; Hs.89679; -. DR SMR; Q6NZ93; 25-153. DR Ensembl; ENSG00000109471; Homo sapiens. DR HGNC; HGNC:6001; IL2. DR ArrayExpress; Q6NZ93; -. DR RZPD-ProtExp; IOH40161; -. DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB. DR GO; GO:0005134; F:interleukin-2 receptor binding; ISS:UniProtKB. DR GO; GO:0019209; F:kinase activator activity; ISS:UniProtKB. DR GO; GO:0006916; P:anti-apoptosis; ISS:UniProtKB. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; ISS:UniProtKB. DR GO; GO:0007155; P:cell adhesion; ISS:UniProtKB. DR GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB. DR GO; GO:0030101; P:natural killer cell activation; ISS:UniProtKB. DR GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB. DR GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. DR GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB. DR InterPro; IPR012351; 4_helix_cytokine_core. DR InterPro; IPR000779; Interleukin-2. DR Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1. DR PANTHER; PTHR11443; Interleukin-2; 1. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR ProDom; PD003649; Interleukin-2; 1. DR SMART; SM00189; IL2; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. SQ SEQUENCE 153 AA; 17598 MW; 1942F50F25960E88 CRC64; MYRMQLLSCI ALSLALVANS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT //