ID Q6NZ93_HUMAN Unreviewed; 153 AA. AC Q6NZ93; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 12-DEC-2006, entry version 21. DE Interleukin 2. GN Name=IL2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=PCR rescued clones; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=PCR rescued clones; RG NIH MGC Project; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Produced by T-cells in response to antigenic or CC mitogenic stimulation, this protein is required for T-cell CC proliferation and other activities crucial to regulation of the CC immune response. Can stimulate B-cells, monocytes, lymphokine- CC activated killer cells, natural killer cells, and glioma cells (By CC similarity). CC -!- SUBCELLULAR LOCATION: Secreted protein (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC066254; AAH66254.1; -; mRNA. DR SMR; Q6NZ93; 25-153. DR Ensembl; ENSG00000109471; Homo sapiens. DR ArrayExpress; Q6NZ93; -. DR RZPD-ProtExp; IOH40161; -. DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB. DR GO; GO:0005134; F:interleukin-2 receptor binding; ISS:UniProtKB. DR GO; GO:0019209; F:kinase activator activity; ISS:UniProtKB. DR GO; GO:0006916; P:anti-apoptosis; ISS:UniProtKB. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; ISS:UniProtKB. DR GO; GO:0007155; P:cell adhesion; ISS:UniProtKB. DR GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB. DR GO; GO:0006955; P:immune response; ISS:UniProtKB. DR GO; GO:0030101; P:natural killer cell activation; ISS:UniProtKB. DR GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB. DR GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. DR GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB. DR InterPro; IPR009079; 4_helix_cytokine. DR InterPro; IPR012351; Cytokine_4_hlx. DR InterPro; IPR000779; Interleukin-2. DR Gene3D; G3DSA:1.20.120.200; Cytokine_4_hlx; 1. DR PANTHER; PTHR11443; Interleukin-2; 1. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR ProDom; PD003649; Interleukin-2; 1. DR SMART; SM00189; IL2; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. KW Cytokine; Growth factor; Immune response. SQ SEQUENCE 153 AA; 17598 MW; 1942F50F25960E88 CRC64; MYRMQLLSCI ALSLALVANS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT //