ID Q6NZ93_HUMAN PRELIMINARY; PRT; 153 AA. AC Q6NZ93; DT 05-JUL-2004 (TrEMBLrel. 27, Created) DT 05-JUL-2004 (TrEMBLrel. 27, Last sequence update) DT 05-JUL-2004 (TrEMBLrel. 27, Last annotation update) DE Interleukin 2,. GN Name=IL2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=PCR rescued clones; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RG Mammalian Gene Collection Program Team; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., RA Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E., RA Jones S.J., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=PCR rescued clones; RA Director MGC Project; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Produced by T-cells in response to antigenic or CC mitogenic stimulation, this protein is required for T-cell CC proliferation and other activities crucial to regulation of the CC immune response. Can stimulate B cells, monocytes, lymphokine- CC activated killer cells, natural killer cells, and glioma cells (By CC similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC066254; AAH66254.1; -; mRNA. DR SMR; Q6NZ93; 25-153. DR GO; GO:0005615; C:extracellular space; ISS. DR GO; GO:0005134; F:interleukin-2 receptor binding; ISS. DR GO; GO:0019209; F:kinase activator activity; ISS. DR GO; GO:0006916; P:anti-apoptosis; ISS. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; ISS. DR GO; GO:0007155; P:cell adhesion; ISS. DR GO; GO:0007267; P:cell-cell signaling; ISS. DR GO; GO:0006955; P:immune response; ISS. DR GO; GO:0030101; P:natural killer cell activation; ISS. DR GO; GO:0030307; P:positive regulation of cell growth; ISS. DR GO; GO:0008284; P:positive regulation of cell proliferation; ISS. DR GO; GO:0030217; P:T-cell differentiation; ISS. DR InterPro; IPR000779; Interleukin-2. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR ProDom; PD003649; Interleukin-2; 1. DR SMART; SM00189; IL2; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. KW Cytokine; Growth factor; Immune response. SQ SEQUENCE 153 AA; 17597 MW; 1942F50F25960E88 CRC64; MYRMQLLSCI ALSLALVANS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT //