ID CDPF1_HUMAN Reviewed; 123 AA. AC Q6NVV7; A6NCA1; A9IU12; A9IU16; Q3ZCR8; DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 29-SEP-2021, entry version 122. DE RecName: Full=Cysteine-rich DPF motif domain-containing protein 1; GN Name=CDPF1; Synonyms=C22orf40; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., RA Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain, and Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q6NVV7; O14503: BHLHE40; NbExp=3; IntAct=EBI-2802782, EBI-711810; CC Q6NVV7; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-2802782, EBI-744545; CC Q6NVV7; Q02930-3: CREB5; NbExp=3; IntAct=EBI-2802782, EBI-10192698; CC Q6NVV7; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-2802782, EBI-742054; CC Q6NVV7; O95967: EFEMP2; NbExp=3; IntAct=EBI-2802782, EBI-743414; CC Q6NVV7; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-2802782, EBI-744099; CC Q6NVV7; A4D161: FAM221A; NbExp=3; IntAct=EBI-2802782, EBI-11960181; CC Q6NVV7; O43559: FRS3; NbExp=3; IntAct=EBI-2802782, EBI-725515; CC Q6NVV7; P56524-2: HDAC4; NbExp=3; IntAct=EBI-2802782, EBI-11953488; CC Q6NVV7; P49639: HOXA1; NbExp=3; IntAct=EBI-2802782, EBI-740785; CC Q6NVV7; Q7L273: KCTD9; NbExp=3; IntAct=EBI-2802782, EBI-4397613; CC Q6NVV7; Q8IVT2: MISP; NbExp=3; IntAct=EBI-2802782, EBI-2555085; CC Q6NVV7; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-2802782, EBI-14084211; CC Q6NVV7; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-2802782, EBI-11952651; CC Q6NVV7; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-2802782, EBI-11957216; CC Q6NVV7; Q15915: ZIC1; NbExp=3; IntAct=EBI-2802782, EBI-11963196; CC -!- SIMILARITY: Belongs to the CDPF1 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL078611; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471138; EAW73407.1; -; Genomic_DNA. DR EMBL; BC045796; AAH45796.1; -; mRNA. DR EMBL; BC067871; AAH67871.1; -; mRNA. DR CCDS; CCDS33670.1; -. DR RefSeq; NP_997210.3; NM_207327.4. DR RefSeq; XP_011528267.1; XM_011529965.2. DR BioGRID; 127293; 19. DR IntAct; Q6NVV7; 18. DR iPTMnet; Q6NVV7; -. DR PhosphoSitePlus; Q6NVV7; -. DR BioMuta; CDPF1; -. DR DMDM; 74749009; -. DR EPD; Q6NVV7; -. DR jPOST; Q6NVV7; -. DR MassIVE; Q6NVV7; -. DR MaxQB; Q6NVV7; -. DR PaxDb; Q6NVV7; -. DR PeptideAtlas; Q6NVV7; -. DR PRIDE; Q6NVV7; -. DR ProteomicsDB; 66725; -. DR Antibodypedia; 13834; 37 antibodies. DR DNASU; 150383; -. DR Ensembl; ENST00000314567; ENSP00000325301; ENSG00000205643. DR GeneID; 150383; -. DR KEGG; hsa:150383; -. DR UCSC; uc003bhe.4; human. DR CTD; 150383; -. DR GeneCards; CDPF1; -. DR HGNC; HGNC:33710; CDPF1. DR HPA; ENSG00000205643; Low tissue specificity. DR neXtProt; NX_Q6NVV7; -. DR OpenTargets; ENSG00000205643; -. DR PharmGKB; PA162379006; -. DR VEuPathDB; HostDB:ENSG00000205643; -. DR eggNOG; KOG4543; Eukaryota. DR GeneTree; ENSGT00390000007925; -. DR HOGENOM; CLU_138011_0_0_1; -. DR InParanoid; Q6NVV7; -. DR OMA; MHELVHY; -. DR OrthoDB; 1278628at2759; -. DR PhylomeDB; Q6NVV7; -. DR TreeFam; TF313933; -. DR PathwayCommons; Q6NVV7; -. DR BioGRID-ORCS; 150383; 2 hits in 1012 CRISPR screens. DR ChiTaRS; CDPF1; human. DR GenomeRNAi; 150383; -. DR Pharos; Q6NVV7; Tdark. DR PRO; PR:Q6NVV7; -. DR Proteomes; UP000005640; Chromosome 22. DR RNAct; Q6NVV7; protein. DR Bgee; ENSG00000205643; Expressed in quadriceps femoris and 151 other tissues. DR ExpressionAtlas; Q6NVV7; baseline and differential. DR Genevisible; Q6NVV7; HS. DR InterPro; IPR042426; CDPF1. DR InterPro; IPR018785; Cys-rich_DPF. DR PANTHER; PTHR31849; PTHR31849; 1. DR Pfam; PF10170; C6_DPF; 1. DR PRINTS; PR01995; UPF0595. PE 1: Evidence at protein level; KW Reference proteome. FT CHAIN 1..123 FT /note="Cysteine-rich DPF motif domain-containing protein 1" FT /id="PRO_0000341360" FT REGION 102..123 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 5 FT /note="V -> A (in dbSNP:rs9627281)" FT /id="VAR_044058" FT VARIANT 70 FT /note="L -> R (in dbSNP:rs55641018)" FT /id="VAR_062237" FT CONFLICT 103 FT /note="Q -> R (in Ref. 3; AAH45796)" FT /evidence="ECO:0000305" SQ SEQUENCE 123 AA; 13877 MW; 87E30A594058235F CRC64; MASHVECRPL GVFECELCTL TAPYSYVGQK PPNTQSMVLL EESYVMKDPF TSDKDRFLVL GSCCSLCSRL VCVGPECSLF YSKRFCLPCV RENINAFPQE IRQDLEKRKA PSKRTPSQPG SRT //