ID ZSC25_HUMAN Reviewed; 544 AA. AC Q6NSZ9; A4D290; D6W5T5; Q14C82; Q14C99; Q5EBM9; Q6DJZ0; Q6N032; Q6ZML3; DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot. DT 13-NOV-2007, sequence version 3. DT 27-MAR-2024, entry version 176. DE RecName: Full=Zinc finger and SCAN domain-containing protein 25; DE AltName: Full=Zinc finger protein 498; GN Name=ZSCAN25; Synonyms=ZNF498; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Spleen; RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.; RT "The nucleotide sequence of a long cDNA clone isolated from human spleen."; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Fetal brain; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., RA Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-544 (ISOFORM 1), AND NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] OF 7-544 (ISOFORMS 2 AND 4). RC TISSUE=Lung, and Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-128, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25755297; DOI=10.1074/mcp.o114.044792; RA Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., RA Vertegaal A.C.; RT "System-wide analysis of SUMOylation dynamics in response to replication RT stress reveals novel small ubiquitin-like modified target proteins and RT acceptor lysines relevant for genome stability."; RL Mol. Cell. Proteomics 14:1419-1434(2015). RN [8] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-3; LYS-22; LYS-128; LYS-278 AND RP LYS-285, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}. CC -!- INTERACTION: CC Q6NSZ9-2; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-14650477, EBI-3866279; CC Q6NSZ9-2; P68400: CSNK2A1; NbExp=3; IntAct=EBI-14650477, EBI-347804; CC Q6NSZ9-2; Q92997: DVL3; NbExp=3; IntAct=EBI-14650477, EBI-739789; CC Q6NSZ9-2; P57086: SCAND1; NbExp=3; IntAct=EBI-14650477, EBI-745846; CC Q6NSZ9-2; P10073: ZSCAN22; NbExp=3; IntAct=EBI-14650477, EBI-10178224; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q6NSZ9-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6NSZ9-2; Sequence=VSP_029147; CC Name=3; CC IsoId=Q6NSZ9-3; Sequence=VSP_029145; CC Name=4; CC IsoId=Q6NSZ9-4; Sequence=VSP_029146; CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAI14574.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAI14942.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; CC Sequence=BAD18712.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=EAL23869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK160369; BAD18712.1; ALT_INIT; mRNA. DR EMBL; BX640720; CAE45839.1; -; mRNA. DR EMBL; CH236956; EAL23869.1; ALT_SEQ; Genomic_DNA. DR EMBL; CH471091; EAW76643.1; -; Genomic_DNA. DR EMBL; CH471091; EAW76646.1; -; Genomic_DNA. DR EMBL; CH471091; EAW76647.1; -; Genomic_DNA. DR EMBL; BC069644; AAH69644.2; -; mRNA. DR EMBL; BC074902; AAH74902.3; -; mRNA. DR EMBL; BC074903; AAH74903.3; -; mRNA. DR EMBL; BC089402; AAH89402.1; -; mRNA. DR EMBL; BC114573; AAI14574.1; ALT_INIT; mRNA. DR EMBL; BC114941; AAI14942.1; ALT_SEQ; mRNA. DR CCDS; CCDS5671.2; -. [Q6NSZ9-1] DR RefSeq; NP_660090.2; NM_145115.2. [Q6NSZ9-1] DR RefSeq; XP_005250251.1; XM_005250194.2. DR RefSeq; XP_011514207.1; XM_011515905.2. [Q6NSZ9-1] DR RefSeq; XP_011514208.1; XM_011515906.2. DR RefSeq; XP_011514209.1; XM_011515907.2. [Q6NSZ9-1] DR RefSeq; XP_011514210.1; XM_011515908.2. DR RefSeq; XP_016867313.1; XM_017011824.1. DR RefSeq; XP_016867314.1; XM_017011825.1. DR RefSeq; XP_016867315.1; XM_017011826.1. DR AlphaFoldDB; Q6NSZ9; -. DR SMR; Q6NSZ9; -. DR BioGRID; 128753; 74. DR IntAct; Q6NSZ9; 30. DR STRING; 9606.ENSP00000377708; -. DR GlyGen; Q6NSZ9; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q6NSZ9; -. DR PhosphoSitePlus; Q6NSZ9; -. DR BioMuta; ZSCAN25; -. DR DMDM; 160359044; -. DR EPD; Q6NSZ9; -. DR jPOST; Q6NSZ9; -. DR MassIVE; Q6NSZ9; -. DR MaxQB; Q6NSZ9; -. DR PaxDb; 9606-ENSP00000377708; -. DR PeptideAtlas; Q6NSZ9; -. DR ProteomicsDB; 66645; -. [Q6NSZ9-1] DR ProteomicsDB; 66646; -. [Q6NSZ9-2] DR ProteomicsDB; 66647; -. [Q6NSZ9-3] DR ProteomicsDB; 66648; -. [Q6NSZ9-4] DR Pumba; Q6NSZ9; -. DR ABCD; Q6NSZ9; 2 sequenced antibodies. DR Antibodypedia; 30418; 211 antibodies from 25 providers. DR DNASU; 221785; -. DR Ensembl; ENST00000334715.7; ENSP00000334800.3; ENSG00000197037.11. [Q6NSZ9-1] DR Ensembl; ENST00000394150.5; ENSP00000377706.1; ENSG00000197037.11. [Q6NSZ9-4] DR Ensembl; ENST00000394152.7; ENSP00000377708.2; ENSG00000197037.11. [Q6NSZ9-1] DR GeneID; 221785; -. DR KEGG; hsa:221785; -. DR MANE-Select; ENST00000394152.7; ENSP00000377708.2; NM_145115.3; NP_660090.2. DR UCSC; uc003url.1; human. [Q6NSZ9-1] DR AGR; HGNC:21961; -. DR CTD; 221785; -. DR DisGeNET; 221785; -. DR GeneCards; ZSCAN25; -. DR HGNC; HGNC:21961; ZSCAN25. DR HPA; ENSG00000197037; Low tissue specificity. DR neXtProt; NX_Q6NSZ9; -. DR OpenTargets; ENSG00000197037; -. DR PharmGKB; PA134962723; -. DR VEuPathDB; HostDB:ENSG00000197037; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000162113; -. DR HOGENOM; CLU_002678_53_4_1; -. DR InParanoid; Q6NSZ9; -. DR OMA; VCGECWK; -. DR OrthoDB; 2882612at2759; -. DR PhylomeDB; Q6NSZ9; -. DR TreeFam; TF350842; -. DR PathwayCommons; Q6NSZ9; -. DR Reactome; R-HSA-212436; Generic Transcription Pathway. DR SignaLink; Q6NSZ9; -. DR BioGRID-ORCS; 221785; 15 hits in 1171 CRISPR screens. DR ChiTaRS; ZSCAN25; human. DR GenomeRNAi; 221785; -. DR Pharos; Q6NSZ9; Tdark. DR PRO; PR:Q6NSZ9; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q6NSZ9; Protein. DR Bgee; ENSG00000197037; Expressed in tibialis anterior and 159 other cell types or tissues. DR ExpressionAtlas; Q6NSZ9; baseline and differential. DR Genevisible; Q6NSZ9; HS. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd07765; KRAB_A-box; 1. DR CDD; cd07936; SCAN; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7. DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR003309; SCAN_dom. DR InterPro; IPR038269; SCAN_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24390:SF197; GH18834P-RELATED; 1. DR PANTHER; PTHR24390; ZINC FINGER PROTEIN; 1. DR Pfam; PF02023; SCAN; 1. DR Pfam; PF00096; zf-C2H2; 7. DR SMART; SM00431; SCAN; 1. DR SMART; SM00355; ZnF_C2H2; 7. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1. DR PROSITE; PS50804; SCAN_BOX; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7. PE 1: Evidence at protein level; KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; KW Reference proteome; Repeat; Transcription; Transcription regulation; KW Ubl conjugation; Zinc; Zinc-finger. FT CHAIN 1..544 FT /note="Zinc finger and SCAN domain-containing protein 25" FT /id="PRO_0000309332" FT DOMAIN 42..124 FT /note="SCAN box" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187" FT ZN_FING 348..370 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 375..397 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 403..425 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 431..453 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 459..480 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 486..508 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 514..536 FT /note="C2H2-type 7; degenerate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT REGION 157..189 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CROSSLNK 3 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 22 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 128 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:25755297, FT ECO:0007744|PubMed:28112733" FT CROSSLNK 278 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 285 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT VAR_SEQ 1..216 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_029145" FT VAR_SEQ 130..544 FT /note="VPCHRQGEQEETALCRGAWEPGIQLGPVEVKPEWGMPPGEGVQGPDPGTEEQ FT LSQDPGDETRAFQEQALPVLQAGPGLPAVNPRDQEMAAGFFTAGSQGLGPFKDMALAFP FT EEEWRHVTPAQIDCFGEYVEPQDCRVSPGGGSKEKEAKPPQEDLKGALVALTSERFGEA FT SLQGPGLGRVCEQEPGGPAGSAPGLPPPQHGAIPLPDEVKTHSSFWKPFQCPECGKGFS FT RSSNLVRHQRTHEEKSYGCVECGKGFTLREYLMKHQRTHLGKRPYVCSECWKTFSQRHH FT LEVHQRSHTGEKPYKCGDCWKSFSRRQHLQVHRRTHTGEKPYTCECGKSFSRNANLAVH FT RRAHTGEKPYGCQVCGKRFSKGERLVRHQRIHTGEKPYHCPACGRSFNQRSILNRHQKT FT QHRQEPLVQ -> VGSMPQAGRAGGNSTLQRRLGARHPAGASGGQA (in isoform FT 4)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:17974005" FT /id="VSP_029146" FT VAR_SEQ 197..268 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_029147" FT VARIANT 325 FT /note="P -> A (in dbSNP:rs10239632)" FT /id="VAR_036931" SQ SEQUENCE 544 AA; 61474 MW; E63AA7ACDA7E7E8B CRC64; MLKEHPEMAE APQQQLGIPV VKLEKELPWG RGREDPSPET FRLRFRQFRY QEAAGPQEAL RELQELCRRW LRPELHTKEQ ILELLVLEQF LTILPREFYA WIREHGPESG KALAAMVEDL TERALEAKAV PCHRQGEQEE TALCRGAWEP GIQLGPVEVK PEWGMPPGEG VQGPDPGTEE QLSQDPGDET RAFQEQALPV LQAGPGLPAV NPRDQEMAAG FFTAGSQGLG PFKDMALAFP EEEWRHVTPA QIDCFGEYVE PQDCRVSPGG GSKEKEAKPP QEDLKGALVA LTSERFGEAS LQGPGLGRVC EQEPGGPAGS APGLPPPQHG AIPLPDEVKT HSSFWKPFQC PECGKGFSRS SNLVRHQRTH EEKSYGCVEC GKGFTLREYL MKHQRTHLGK RPYVCSECWK TFSQRHHLEV HQRSHTGEKP YKCGDCWKSF SRRQHLQVHR RTHTGEKPYT CECGKSFSRN ANLAVHRRAH TGEKPYGCQV CGKRFSKGER LVRHQRIHTG EKPYHCPACG RSFNQRSILN RHQKTQHRQE PLVQ //