ID Q6MZV6_HUMAN Unreviewed; 479 AA. AC Q6MZV6; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 28-JUN-2023, entry version 97. DE SubName: Full=Uncharacterized protein DKFZp686L19235 {ECO:0000313|EMBL:CAE45921.1}; GN Name=DKFZp686L19235 {ECO:0000313|EMBL:CAE45921.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAE45921.1}; RN [1] {ECO:0000313|EMBL:CAE45921.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Human small intestine {ECO:0000313|EMBL:CAE45921.1}; RG The German Human cDNA Consortium; RA Bloecker H., Boecher M., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., RA Han M., Wiemann S.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0007829|PDB:7TTZ} RP X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 242-460, AND DISULFIDE BONDS. RX PubMed=36343329; DOI=10.1080/19420862.2022.2141637; RA Heinkel F., Verstraete M.M., Cao S., Li J., Farber P., Stangle E., RA Silva-Moreno B., Peng F., Dixit S., Boulanger M.J., RA Spreter Von Kreudenstein T., Escobar-Cabrera E.; RT "Engineering a pure and stable heterodimeric IgA for the development of RT multispecific therapeutics."; RL MAbs 14:2141637-2141637(2022). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX640854; CAE45921.1; -; mRNA. DR PDB; 7TTZ; X-ray; 2.35 A; A/B=242-460. DR AlphaFoldDB; Q6MZV6; -. DR SMR; Q6MZV6; -. DR IntAct; Q6MZV6; 1. DR MaxQB; Q6MZV6; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR CDD; cd04986; IgC1_CH2_IgA; 1. DR CDD; cd05768; IgC1_CH3_IgAGD_CH4_IgAEM; 1. DR CDD; cd04981; IgV_H; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 4. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR23411:SF31; IMMUNOGLOBULIN HEAVY CONSTANT ALPHA 1-RELATED; 1. DR PANTHER; PTHR23411; TAPASIN; 1. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 4. DR SMART; SM00407; IGc1; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00406; IGv; 1. DR SUPFAM; SSF48726; Immunoglobulin; 4. DR PROSITE; PS50835; IG_LIKE; 4. DR PROSITE; PS00290; IG_MHC; 2. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:7TTZ}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..479 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5004277090" FT DOMAIN 18..115 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 145..237 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 251..346 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 354..456 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DISULFID 249..308 FT /evidence="ECO:0007829|PDB:7TTZ" FT DISULFID 273..330 FT /evidence="ECO:0007829|PDB:7TTZ" FT DISULFID 306 FT /note="Interchain" FT /evidence="ECO:0007829|PDB:7TTZ" FT DISULFID 376..439 FT /evidence="ECO:0007829|PDB:7TTZ" SQ SEQUENCE 479 AA; 51639 MW; 6FA495DF0AA71DD4 CRC64; MELGLCWVFL VAILEGVPCE VQLVESGGGL VQPGGSLRLS CAASGFTVSN YGIHWVRQAP GKGLEWISFL SYTTDTIHYA DSVKGRFTIS RDNAKNSLYL QMNSLRDEDT GFYYCVRSAA GSDIWVDPWG QGTLVTVSSA SPTSPKVFPL SLDSTPQDGN VVVACLVQGF FPQEPLSVTW SESGQNVTAR NFPPSQDASG DLYTTSSQLT LPATQCPDGK SVTCHVKHYT NPSQDVTVPC PVPPPPPCCH PRLSLHRPAL EDLLLGSEAN LTCTLTGLRD ASGATFTWTP SSGKSAVQGP PERDLCGCYS VSSVLPGCAQ PWNHGETFTC TAAHPELKTP LTANITKSGN TFRPEVHLLP PPSEELALNE LVTLTCLARG FSPKDVLVRW LQGSQELPRE KYLTWASRQE PSQGTTTFAV TSILRVAAED WKKGDTFSCM VGHEALPLAF TQKTIDRLAG KPTHVNVSVV MAEVDGTCY //