ID Q6MTI5_MYCMS Unreviewed; 447 AA. AC Q6MTI5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 06-FEB-2013, entry version 74. DE RecName: Full=Signal recognition particle protein; DE AltName: Full=Fifty-four homolog; GN Name=ffh; OrderedLocusNames=MSC_0423; OS Mycoplasma mycoides subsp. mycoides SC (strain PG1). OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma. OX NCBI_TaxID=272632; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PG1; RX PubMed=14762060; DOI=10.1101/gr.1673304; RA Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., RA Johansson K.-E., Pettersson B., Uhleen M.; RT "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type RT strain PG1T, the causative agent of contagious bovine pleuropneumonia RT (CBPP)."; RL Genome Res. 14:221-227(2004). CC -!- FUNCTION: Involved in targeting and insertion of nascent membrane CC proteins into the cytoplasmic membrane. Binds to the hydrophobic CC signal sequence of the ribosome-nascent chain (RNC) as it emerges CC from the ribosomes. The SRP-RNC complex is then targeted to the CC cytoplasmic membrane where it interacts with the SRP receptor FtsY CC (By similarity). CC -!- SUBUNIT: Part of the signal recognition particle protein CC translocation system, which is composed of SRP and FtsY (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm. Note=The SRP-RNC complex is CC targeted to the cytoplasmic membrane (By similarity). CC -!- DOMAIN: Composed of three domains: the N-terminal N domain, which CC is responsible for interactions with the ribosome, the central G CC domain, which binds GTP, and the C-terminal M domain, which binds CC the RNA and the signal sequence of the RNC (By similarity). CC -!- SIMILARITY: Belongs to the GTP-binding SRP family. SRP54 CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX293980; CAE77051.1; -; Genomic_DNA. DR RefSeq; NP_975409.1; NC_005364.2. DR ProteinModelPortal; Q6MTI5; -. DR GeneID; 2744883; -. DR GenomeReviews; BX293980_GR; MSC_0423. DR KEGG; mmy:MSC_0423; -. DR PATRIC; 20017616; VBIMycMyc4973_0461. DR HOGENOM; HOG000036164; -. DR KO; K03106; -. DR OMA; GQQVVKI; -. DR ProtClustDB; PRK10867; -. DR BioCyc; MMYC272632:GI1G-399-MONOMER; -. DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW. DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro. DR GO; GO:0005525; F:GTP binding; IEA:HAMAP. DR GO; GO:0003924; F:GTPase activity; IEA:HAMAP. DR GO; GO:0006184; P:GTP catabolic process; IEA:GOC. DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. DR Gene3D; 1.20.120.140; SRP54_helical; 1. DR Gene3D; 1.10.260.30; SRP54_M; 1. DR HAMAP; MF_00306; SRP54; 1; -. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR013822; Signal_recog_particl_SRP54_hlx. DR InterPro; IPR004125; Signal_recog_particle_SRP54_M. DR InterPro; IPR022941; SRP54. DR InterPro; IPR000897; SRP54_GTPase_dom. DR InterPro; IPR004780; SRP_Ffh. DR PANTHER; PTHR11564:SF7; PTHR11564:SF7; 1. DR Pfam; PF00448; SRP54; 1. DR Pfam; PF02881; SRP54_N; 1. DR Pfam; PF02978; SRP_SPB; 1. DR SMART; SM00382; AAA; 1. DR SMART; SM00962; SRP54; 1. DR SMART; SM00963; SRP54_N; 1. DR SUPFAM; SSF47446; Signal_recog_particle_SRP54_M; 1. DR SUPFAM; SSF47364; SRP54; 1. DR TIGRFAMs; TIGR00959; ffh; 1. DR PROSITE; PS00300; SRP54; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; KW Reference proteome; Ribonucleoprotein; RNA-binding; KW Signal recognition particle. FT NP_BIND 108 115 GTP (By similarity). FT NP_BIND 190 194 GTP (By similarity). FT NP_BIND 248 251 GTP (By similarity). SQ SEQUENCE 447 AA; 50161 MW; D27FE990C7FDD479 CRC64; MGFGDFLSKR MQKSIEKNMK NSTLNEENIK ETLKEIRLSL LEADVNIEAT KEIINNVKQK ALGGYIFEGA NAHQQMIKIV HEELVNILGK ENAPLELNKK PSVVMMVGLQ GSGKTTTANK LAYLLNKKNK KKVLLVGLDI YRPGAIEQLI QLGQKTNIQV FEKGKQDPIL TAQEALEYAQ ENNFDVVILD TAGRLQVDQV LMTELDNLKK KTSPSEILLV VDGMSGQEII NVTNEFNSKL KLSGVVVTKL DGDARGGATL SISYLTKLPI KFIGEGEGYN ALAAFYPKRM ADRLMGMGDI ETLFEKAVEN IDERSIQKTM NRMFLGQFDL EDLRNQLAQI AKMGSLNKLM KMLPINKVSE TQIQDAQRKL AVFSILMDSM TLKERRDPRV LKAISRKNRI IKGSGRTEKE FNELINSFEK GKKQVLEITK MIKSGRMPNL SKGGFKF //